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Osteoporosis occurs when osteoclast activity surpasses osteoblast activity. Our previous studies showed the plant-derived natural polysaccharide (Polygonatum sibiricum polysaccharide or PSP) had significant anti-ovariectomy (OVX)-induced osteoporosis effects\n                    <jats:italic>in vivo<\/jats:italic>\n                    , but the mechanisms of PSP\u2019s anti-osteoporosis effect remains unclear. In this study, we assessed PSP\u2019s effect on the generation of osteoblast and osteoclast\n                    <jats:italic>in vitro<\/jats:italic>\n                    . This study showed that PSP promoted the osteogenic differentiation of mouse bone marrow stromal cells (BMSCs) without affecting BMPs signaling pathway. This effect was due to the increased nuclear accumulation of \u03b2-catenin, resulting in a higher expression of osteoblast-related genes. Furthermore, the study showed PSP could inhibit the receptor activator of nuclear factor-\u03baB ligand (RANKL)-induced osteoclastogenesis and exert prophylatic protection against LPS-induced osteolysis\n                    <jats:italic>in vivo<\/jats:italic>\n                    . This effect was also related to the increased nuclear accumulation of \u03b2-catenin, resulting in the decreased expression of osteoclast-related genes. In conclusion, our results showed that PSP effectively promoted the osteogenic differentiation of mouse BMSCs and suppressed osteoclastogenesis; therefore, it could be used to treat osteoporosis.\n                  <\/jats:p>","DOI":"10.1038\/srep32261","type":"journal-article","created":{"date-parts":[[2016,8,24]],"date-time":"2016-08-24T05:14:50Z","timestamp":1472015690000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":67,"title":["Polygonatum sibiricum polysaccharide inhibits osteoporosis by promoting osteoblast formation and blocking osteoclastogenesis through Wnt\/\u03b2-catenin signalling pathway"],"prefix":"10.1038","volume":"6","author":[{"given":"Li","family":"Du","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng-Ni","family":"Nong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-Min","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Ming","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shao-Hui","family":"Zong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gao-Feng","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,8,24]]},"reference":[{"key":"BFsrep32261_CR1","doi-asserted-by":"publisher","first-page":"1523","DOI":"10.1016\/j.fitote.2012.08.020","volume":"83","author":"A Jun","year":"2012","unstructured":"Jun, A. et al. 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