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Many studies have shown that microRNAs (miRNAs) regulate the expression of multiple genes that play a significant role in spermatogenesis and development. We previously showed that microRNA-210 (miR-210) is one of the markedly upregulated microRNAs in the testes of sterile males with maturation arrest (MA). However, the role of miR-210 in spermatogenesis remains unknown. In this study, we found that miR-210 is highly expressed not only in patients with MA but also in patients with cryptorchidism. In addition, miR-210 inhibits the expression of Nuclear Receptor Subfamily 1, Group D, Member 2 (NR1D2) both <jats:italic>in vitro<\/jats:italic> and <jats:italic>in vivo<\/jats:italic>, particularly in cryptorchidic tissues. To facilitate further research, we established a mouse model of cryptorchidism and were surprised to discover that the miR-210 expression pattern was in accordance with that of patients with cryptorchidism. Thus, we propose that miR-210 may serve as a biomarker of cryptorchidism in clinical tests.<\/jats:p>","DOI":"10.1038\/srep32265","type":"journal-article","created":{"date-parts":[[2016,8,26]],"date-time":"2016-08-26T11:26:39Z","timestamp":1472210799000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["The functional and predictive roles of miR-210 in cryptorchidism"],"prefix":"10.1038","volume":"6","author":[{"given":"Zhengzheng","family":"Duan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helong","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,8,26]]},"reference":[{"key":"BFsrep32265_CR1","doi-asserted-by":"publisher","first-page":"s41","DOI":"10.1038\/ncb-nm-fertilityS41","volume":"4","author":"MM Matzuk","year":"2002","unstructured":"Matzuk, M. 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