{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T18:38:30Z","timestamp":1760985510476},"reference-count":49,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Huntington\u2019s disease (HD) is a genetically-determined neurodegenerative disease. Characterising neuropathology in mouse models of HD is commonly restricted to cross-sectional <jats:italic>ex vivo<\/jats:italic> analyses, beset by tissue fixation issues. <jats:italic>In vivo<\/jats:italic> longitudinal magnetic resonance imaging (MRI) allows for disease progression to be probed non-invasively. In the HdhQ150 mouse model of HD, <jats:italic>in vivo<\/jats:italic> MRI was employed at two time points, before and after the onset of motor signs, to assess brain macrostructure and white matter microstructure. <jats:italic>Ex vivo<\/jats:italic> MRI, immunohistochemistry, transmission electron microscopy and behavioural testing were also conducted. Global brain atrophy was found in HdhQ150 mice at both time points, with no neuropathological progression across time and a selective sparing of the cerebellum. In contrast, no white matter abnormalities were detected from the MRI images or electron microscopy images alike. The relationship between motor function and MR-based structural measurements was different for the HdhQ150 and wild-type mice, although there was no relationship between motor deficits and histopathology. Widespread neuropathology prior to symptom onset is consistent with patient studies, whereas the absence of white matter abnormalities conflicts with patient data. The myriad reasons for this inconsistency require further attention to improve the translatability from mouse models of disease.<\/jats:p>","DOI":"10.1038\/srep32423","type":"journal-article","created":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T10:53:19Z","timestamp":1472727199000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Longitudinal in vivo MRI in a Huntington\u2019s disease mouse model: Global atrophy in the absence of white matter microstructural damage"],"prefix":"10.1038","volume":"6","author":[{"given":"Jessica J.","family":"Steventon","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca C.","family":"Trueman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Da","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emma","family":"Yhnell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zubeyde","family":"Bayram-Weston","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc","family":"Modat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge","family":"Cardoso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebastian","family":"Ourselin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Lythgoe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Stewart","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne E.","family":"Rosser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Derek K.","family":"Jones","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2016,9,1]]},"reference":[{"key":"BFsrep32423_CR1","doi-asserted-by":"crossref","unstructured":"A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington\u2019s disease chromosomes. The Huntington\u2019s Disease Collaborative Research Group. Cell 72, 971\u2013983 (1993).","DOI":"10.1016\/0092-8674(93)90585-E"},{"key":"BFsrep32423_CR2","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.brainresbull.2011.10.002","volume":"88","author":"SP Brooks","year":"2012","unstructured":"Brooks, S. P., Jones, L. & Dunnett, S. B. Comparative analysis of pathology and behavioural phenotypes in mouse models of Huntington\u2019s disease. Brain Res. Bull. 88, 81\u201393 (2012).","journal-title":"Brain Res. Bull."},{"key":"BFsrep32423_CR3","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1002\/hbm.21205","volume":"33","author":"EM Dumas","year":"2012","unstructured":"Dumas, E. M. et al. Early changes in white matter pathways of the sensorimotor cortex in premanifest Huntington\u2019s disease. Hum. Brain Mapp. 33, 203\u2013212 (2012).","journal-title":"Hum. Brain Mapp."},{"key":"BFsrep32423_CR4","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.pscychresns.2005.05.011","volume":"140","author":"SAJ Reading","year":"2005","unstructured":"Reading, S. A. J. et al. Regional white matter change in pre-symptomatic Huntington\u2019s disease: a diffusion tensor imaging study. Psychiatry Res. 140, 55\u201362 (2005).","journal-title":"Psychiatry Res"},{"key":"BFsrep32423_CR5","doi-asserted-by":"crossref","unstructured":"Steventon, J. J., Trueman, R. C., Rosser, A. E. & Jones, D. K. Robust MR-based approaches to quantifying white matter structure and structure\/function alterations in Huntington\u2019s disease. J. Neurosci. Methods, doi: 10.1016\/j.jneumeth.2015.08.027 (2015).","DOI":"10.1016\/j.jneumeth.2015.08.027"},{"key":"BFsrep32423_CR6","doi-asserted-by":"crossref","first-page":"2995","DOI":"10.1016\/j.neuroimage.2009.10.015","volume":"49","author":"HD Rosas","year":"2010","unstructured":"Rosas, H. D. et al. Altered white matter microstructure in the corpus callosum in Huntington\u2019s disease: implications for cortical \u2018disconnection\u2019. Neuroimage 49, 2995\u20133004 (2010).","journal-title":"Neuroimage"},{"key":"BFsrep32423_CR7","doi-asserted-by":"crossref","first-page":"2382","DOI":"10.1016\/j.neurobiolaging.2014.04.024","volume":"35","author":"M Marangoni","year":"2014","unstructured":"Marangoni, M. et al. Age-related axonal swellings precede other neuropathological hallmarks in a knock-in mouse model of Huntington\u2019s disease. Neurobiol. Aging 35, 2382\u20132393 (2014).","journal-title":"Neurobiol. Aging"},{"key":"BFsrep32423_CR8","doi-asserted-by":"crossref","first-page":"5285","DOI":"10.1093\/hmg\/ddv248","volume":"24","author":"RG Gatto","year":"2015","unstructured":"Gatto, R. G. et al. Analysis of YFP(J16)-R6\/2 reporter mice and postmortem brains reveals early pathology and increased vulnerability of callosal axons in Huntington\u2019s disease. Hum. Mol. Genet. 24, 5285\u20135298 (2015).","journal-title":"Hum. Mol. Genet."},{"key":"BFsrep32423_CR9","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1002\/mrm.1105","volume":"45","author":"A Alexander","year":"2001","unstructured":"Alexander, A., Hasan, K. M., Lazar, M., Tsuruda, J. S. & Parker, D. L. Analysis of partial volume effects in diffusion-tensor MRI. Magn Reson Med 45, 770\u2013780 (2001).","journal-title":"Magn Reson Med"},{"key":"BFsrep32423_CR10","doi-asserted-by":"crossref","first-page":"e60012","DOI":"10.1371\/journal.pone.0060012","volume":"8","author":"I Rattray","year":"2013","unstructured":"Rattray, I. et al. Correlations of behavioral deficits with brain pathology assessed through longitudinal MRI and histopathology in the R6\/2 mouse model of HD. PLoS One 8, e60012 (2013).","journal-title":"PLoS One"},{"key":"BFsrep32423_CR11","doi-asserted-by":"crossref","first-page":"149","DOI":"10.3233\/JHD-150147","volume":"4","author":"JJ Steventon","year":"2015","unstructured":"Steventon, J. J. et al. In Vivo MRI Evidence that Neuropathology is Attenuated by Cognitive Enrichment in the Yac128 Huntington\u2019s Disease Mouse Model. J. Huntingtons. Dis. 4, 149\u2013160 (2015).","journal-title":"J. Huntingtons. Dis."},{"key":"BFsrep32423_CR12","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1093\/hmg\/10.2.137","volume":"10","author":"CH Lin","year":"2001","unstructured":"Lin, C. H. et al. Neurological abnormalities in a knock-in mouse model of Huntington\u2019s disease. Hum. Mol. Genet. 10, 137\u2013144 (2001).","journal-title":"Hum. Mol. Genet."},{"key":"BFsrep32423_CR13","doi-asserted-by":"crossref","first-page":"8989","DOI":"10.1523\/JNEUROSCI.1830-07.2007","volume":"27","author":"MY Heng","year":"2007","unstructured":"Heng, M. Y., Tallaksen-Greene, S. J., Detloff, P. J. & Albin, R. L. Longitudinal evaluation of the Hdh(CAG)150 knock-in murine model of Huntington\u2019s disease. J. Neurosci. 27, 8989\u20138998 (2007).","journal-title":"J. Neurosci."},{"key":"BFsrep32423_CR14","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.brainresbull.2011.03.014","volume":"88","author":"Z Bayram-Weston","year":"2012","unstructured":"Bayram-Weston, Z., Torres, E. M., Jones, L., Dunnett, S. B. & Brooks, S. P. Light and electron microscopic characterization of the evolution of cellular pathology in the Hdh(CAG)150 Huntington\u2019s disease knock-in mouse. Brain Res. Bull. 88, 189\u2013198 (2012).","journal-title":"Brain Res. Bull."},{"key":"BFsrep32423_CR15","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1002\/mrm.22055","volume":"62","author":"O Pasternak","year":"2009","unstructured":"Pasternak, O., Sochen, N., Gur, Y., Intrator, N. & Assaf, Y. Free water elimination and mapping from diffusion MRI. Magn. Reson. Med. 62, 717\u2013730 (2009).","journal-title":"Magn. Reson. Med."},{"key":"BFsrep32423_CR16","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1007\/s00415-015-7642-6","volume":"262","author":"RC Wolf","year":"2015","unstructured":"Wolf, R. C. et al. Abnormal cerebellar volume and corticocerebellar dysfunction in early manifest Huntington\u2019s disease. J. Neurol. 262, 859\u2013869 (2015).","journal-title":"J. Neurol."},{"key":"BFsrep32423_CR17","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1016\/j.nbd.2010.07.014","volume":"40","author":"PC Nopoulos","year":"2010","unstructured":"Nopoulos, P. C. et al. Cerebral cortex structure in prodromal Huntington disease. Neurobiol. Dis. 40, 544\u2013554 (2010).","journal-title":"Neurobiol. Dis."},{"key":"BFsrep32423_CR18","doi-asserted-by":"crossref","first-page":"17365","DOI":"10.1523\/JNEUROSCI.2904-12.2012","volume":"32","author":"O Pasternak","year":"2012","unstructured":"Pasternak, O. et al. Excessive Extracellular Volume Reveals a Neurodegenerative Pattern in Schizophrenia Onset. J. Neurosci. 32, 17365\u201317372 (2012).","journal-title":"J. Neurosci."},{"key":"BFsrep32423_CR19","doi-asserted-by":"crossref","first-page":"873","DOI":"10.3171\/2013.12.JNS132090","volume":"120","author":"O Pasternak","year":"2014","unstructured":"Pasternak, O. et al. Hockey Concussion Education Project, Part 2. Microstructural white matter alterations in acutely concussed ice hockey players: a longitudinal free-water MRI study. J. Neurosurg. 120, 873\u2013881 (2014).","journal-title":"J. Neurosurg."},{"key":"BFsrep32423_CR20","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1016\/j.neurobiolaging.2014.10.029","volume":"36","author":"E Ofori","year":"2015","unstructured":"Ofori, E. et al. Increased free water in the substantia nigra of Parkinson\u2019s disease: a single-site and multi-site study. Neurobiol. Aging 36, 1097\u20131104 (2015).","journal-title":"Neurobiol. Aging"},{"key":"BFsrep32423_CR21","doi-asserted-by":"crossref","first-page":"2858","DOI":"10.1093\/cercor\/bhr360","volume":"22","author":"M Di Paola","year":"2012","unstructured":"Di Paola, M. et al. Multimodal MRI analysis of the corpus callosum reveals white matter differences in presymptomatic and early Huntington\u2019s disease. Cereb. Cortex 22, 2858\u20132866 (2012).","journal-title":"Cereb. Cortex"},{"key":"BFsrep32423_CR22","unstructured":"Treuting, P. M. & Dintzis, S. M. Comparative Anatomy and Histology: A Mouse and Human Atlas. (Elsevier., 2012)."},{"key":"BFsrep32423_CR23","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/S1474-4422(13)70088-7","volume":"12","author":"SJ Tabrizi","year":"2013","unstructured":"Tabrizi, S. J. et al. Predictors of phenotypic progression and disease onset in premanifest and early-stage Huntington\u2019s disease in the TRACK-HD study: analysis of 36-month observational data. Lancet. Neurol. 12, 637\u2013649 (2013).","journal-title":"Lancet. Neurol."},{"key":"BFsrep32423_CR24","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S1474-4422(10)70276-3","volume":"10","author":"SJ Tabrizi","year":"2011","unstructured":"Tabrizi, S. J. et al. Biological and clinical changes in premanifest and early stage Huntington\u2019s disease in the TRACK-HD study: the 12-month longitudinal analysis. Lancet. Neurol. 10, 31\u201342 (2011).","journal-title":"Lancet. Neurol."},{"key":"BFsrep32423_CR25","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/S0166-2236(00)01705-7","volume":"23","author":"MF Mehler","year":"2000","unstructured":"Mehler, M. F. & Gokhan, S. Mechanisms underlying neural cell death in neurodegenerative diseases: alterations of a developmentally-mediated cellular rheostat. Trends Neurosci 23, 599\u2013605 (2000).","journal-title":"Trends Neurosci"},{"key":"BFsrep32423_CR26","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/j.neuron.2010.06.027","volume":"67","author":"JD Godin","year":"2010","unstructured":"Godin, J. D. et al. Huntingtin is required for mitotic spindle orientation and mammalian neurogenesis. Neuron 67, 392\u2013406 (2010).","journal-title":"Neuron"},{"key":"BFsrep32423_CR27","doi-asserted-by":"crossref","first-page":"e1004550","DOI":"10.1371\/journal.pgen.1004550","volume":"10","author":"M Mielcarek","year":"2014","unstructured":"Mielcarek, M. et al. Dysfunction of the CNS-heart axis in mouse models of Huntington\u2019s disease. PLoS Genet. 10, e1004550 (2014).","journal-title":"PLoS Genet"},{"key":"BFsrep32423_CR28","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1002\/mds.25862","volume":"29","author":"R Hoffmann","year":"2014","unstructured":"Hoffmann, R. et al. Progressive hepatic mitochondrial dysfunction in premanifest Huntington\u2019s disease. Mov Disord 29, 831\u2013834 (2014).","journal-title":"Mov Disord"},{"key":"BFsrep32423_CR29","doi-asserted-by":"crossref","first-page":"E70","DOI":"10.1093\/ilar.53.1.70","volume":"53","author":"S Gargiulo","year":"2012","unstructured":"Gargiulo, S. et al. Mice anesthesia, analgesia and care, Part II: anesthetic considerations in preclinical imaging studies. ILAR J 53, E70\u2013E81 (2012).","journal-title":"ILAR J"},{"key":"BFsrep32423_CR30","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.brainresbull.2010.05.004","volume":"88","author":"S Brooks","year":"2012","unstructured":"Brooks, S., Higgs, G., Jones, L. & Dunnett, S. B. Longitudinal analysis of the behavioural phenotype in Hdh(CAG)150 Huntington\u2019s disease knock-in mice. Brain Res. Bull. 88, 182\u2013188 (2012).","journal-title":"Brain Res. Bull."},{"key":"BFsrep32423_CR31","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1002\/(SICI)1522-2594(199909)42:3<515::AID-MRM14>3.0.CO;2-Q","volume":"42","author":"DK Jones","year":"1999","unstructured":"Jones, D. K., Horsfield, M. A. & Simmons, A. Optimal strategies for measuring diffusion in anisotropic systems by magnetic resonance imaging. Magn. Reson. Med. 42, 515\u2013525 (1999).","journal-title":"Magn. Reson. Med."},{"key":"BFsrep32423_CR32","unstructured":"Leemans, A., Jeurissen, B. & Sijbers, J. ExploreDTI: a graphical toolbox for processing, analyzing and visualizing diffusion MR data. Proc Intl Soc Mag Reson. (2009)."},{"key":"BFsrep32423_CR33","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1007\/s00436-007-0571-2","volume":"101","author":"S Anand","year":"2007","unstructured":"Anand, S. et al. Immune response studies with Wuchereria bancrofti vespid allergen homologue (WbVAH) in human lymphatic filariasis. Parasitol. Res. 101, 981\u2013988 (2007).","journal-title":"Parasitol. Res."},{"key":"BFsrep32423_CR34","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1002\/mrm.21890","volume":"61","author":"A Leemans","year":"2009","unstructured":"Leemans, A. & Jones, D. K. The B-matrix must be rotated when correcting for subject motion in DTI data. Magn. Reson. Med. 61, 1336\u20131349 (2009).","journal-title":"Magn. Reson. Med."},{"key":"BFsrep32423_CR35","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1002\/nbm.1543","volume":"23","author":"DK Jones","year":"2010","unstructured":"Jones, D. K. & Cercignani, M. Twenty-five pitfalls in the analysis of diffusion MRI data. NMR Biomed. 23, 803\u2013820 (2010).","journal-title":"NMR Biomed."},{"key":"BFsrep32423_CR36","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.1016\/j.neuroimage.2009.09.033","volume":"49","author":"F Dell\u2019Acqua","year":"2010","unstructured":"Dell\u2019Acqua, F. et al. A modified damped Richardson-Lucy algorithm to reduce isotropic background effects in spherical deconvolution. Neuroimage 49, 1446\u20131458 (2010).","journal-title":"Neuroimage"},{"key":"BFsrep32423_CR37","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1111\/j.2042-7158.1968.tb09743.x","volume":"20","author":"BJ Jones","year":"1968","unstructured":"Jones, B. J. & Roberts, D. J. The quantiative measurement of motor inco-ordination in naive mice using an acelerating rotarod. J. Pharm. Pharmacol. 20, 302\u2013304 (1968).","journal-title":"J. Pharm. Pharmacol."},{"key":"BFsrep32423_CR38","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.expneurol.2007.10.012","volume":"210","author":"D Alvarez-Fischer","year":"2008","unstructured":"Alvarez-Fischer, D. et al. Characterization of the striatal 6-OHDA model of Parkinson\u2019s disease in wild type and alpha-synuclein-deleted mice. Exp Neurol 210, 182\u2013193 (2008).","journal-title":"Exp Neurol"},{"key":"BFsrep32423_CR39","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/S0028-3908(00)00005-8","volume":"39","author":"T Schallert","year":"2000","unstructured":"Schallert, T., Fleming, S. M., Leasure, J. L., Tillerson, J. L. & Bland, S. T. CNS plasticity and assessment of forelimb sensorimotor outcome in unilateral rat models of stroke, cortical ablation, parkinsonism and spinal cord injury. Neuropharmacology 39, 777\u2013787 (2000).","journal-title":"Neuropharmacology"},{"key":"BFsrep32423_CR40","doi-asserted-by":"crossref","first-page":"e378","DOI":"10.1038\/tp.2014.18","volume":"4","author":"L Qiu","year":"2014","unstructured":"Qiu, L. et al. Regional increases of cortical thickness in untreated, first-episode major depressive disorder. Transl. Psychiatry 4, e378 (2014).","journal-title":"Transl. Psychiatry"},{"key":"BFsrep32423_CR41","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1016\/j.neuroimage.2009.12.028","volume":"53","author":"AM Winkler","year":"2010","unstructured":"Winkler, A. M. et al. Cortical thickness or grey matter volume? The importance of selecting the phenotype for imaging genetics studies. Neuroimage 53, 1135\u20131146 (2010).","journal-title":"Neuroimage"},{"key":"BFsrep32423_CR42","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1089\/neu.2010.1665","volume":"28","author":"SC Payne","year":"2011","unstructured":"Payne, S. C., Bartlett, C. A., Harvey, A. R., Dunlop, S. A. & Fitzgerald, M. Chronic swelling and abnormal myelination during secondary degeneration after partial injury to a central nervous system tract. J. Neurotrauma 28, 1077\u20131088 (2011).","journal-title":"J. Neurotrauma"},{"key":"BFsrep32423_CR43","doi-asserted-by":"crossref","first-page":"e86576","DOI":"10.1371\/journal.pone.0086576","volume":"9","author":"D Ma","year":"2014","unstructured":"Ma, D. et al. Automatic structural parcellation of mouse brain MRI using multi-atlas label fusion. PLoS One 9, e86576 (2014).","journal-title":"PLoS One"},{"key":"BFsrep32423_CR44","doi-asserted-by":"crossref","unstructured":"Leung, K. et al. Automated brain extraction using multi-atlas propagation and segmentation (MAPS). 8TH IEEE Int. Symp. Biomed. Imaging: From nano to macro. 2053\u20132056 (2011).","DOI":"10.1109\/ISBI.2011.5872816"},{"key":"BFsrep32423_CR45","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1016\/j.neuroscience.2005.07.014","volume":"135","author":"Y Ma","year":"2005","unstructured":"Ma, Y. et al. A three-dimensional digital atlas database of the adult C57BL\/6J mouse brain by magnetic resonance microscopy. Neuroscience 135, 1203\u20131215 (2005).","journal-title":"Neuroscience"},{"key":"BFsrep32423_CR46","first-page":"557","volume":"1935","author":"S Ourselin","year":"2000","unstructured":"Ourselin, S., Roche, A., Prima, S. & Ayache, N. Block matching: A general framework to improve robustness of rigid registration of medical images. Proc MICCAI Int Conf Med Image Comput Comput Assist Interv. 1935, 557\u2013566 (2000).","journal-title":"Proc MICCAI Int Conf Med Image Comput Comput Assist Interv"},{"key":"BFsrep32423_CR47","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1109\/TMI.2004.828354","volume":"23","author":"SK Warfield","year":"2004","unstructured":"Warfield, S. K., Zou, K. H. & Wells, W. M. Simultaneous truth and performance level estimation (STAPLE): an algorithm for the validation of image segmentation. IEEE Trans. Med. Imaging 23, 903\u2013921 (2004).","journal-title":"IEEE Trans. Med. Imaging"},{"key":"BFsrep32423_CR48","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.cmpb.2009.09.002","volume":"98","author":"M Modat","year":"2010","unstructured":"Modat, M. et al. Fast free-form deformation using graphics processing units. Comput Methods Programs Biomed 98, 278\u2013284 (2010).","journal-title":"Comput Methods Programs Biomed"},{"key":"BFsrep32423_CR49","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/j.media.2013.02.006","volume":"17","author":"M Jorge Cardoso","year":"2013","unstructured":"Jorge Cardoso, M. et al. STEPS: Similarity and Truth Estimation for Propagated Segmentations and its application to hippocampal segmentation and brain parcelation. Med Image Anal 17, 671\u2013684 (2013).","journal-title":"Med Image Anal"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/srep32423","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/srep32423.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/srep32423.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,4]],"date-time":"2023-01-04T22:30:03Z","timestamp":1672871403000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/srep32423"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9,1]]},"references-count":49,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2016,10,17]]}},"alternative-id":["BFsrep32423"],"URL":"https:\/\/doi.org\/10.1038\/srep32423","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,9,1]]},"assertion":[{"value":"19 February 2016","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 August 2016","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 September 2016","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing financial interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"32423"}}