{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T17:13:32Z","timestamp":1790356412533,"version":"4.1.0"},"reference-count":56,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Network analysis through graph theory provides a quantitative approach to characterize specific proteins and their constituent assemblies that underlie host-pathogen interactions. In the present study, graph theory was used to analyze the interactome designed out of 50 differentially expressing proteins from proteomic analysis of Chandipura Virus (CHPV, Family: Rhabdoviridae) infected mouse brain tissue to identify the primary candidates for intervention. Using the measure of degree centrality, that quantifies the connectedness of a single protein within a milieu of several other interacting proteins, DJ-1 was selected for further molecular validation. To elucidate the generality of DJ-1\u2019s role in propagating infection its role was also monitored in another RNA virus, Japanese Encephalitis Virus (JEV, Family: Flaviviridae) infection. Concurrently, DJ-1 got over-expressed in response to reactive oxygen species (ROS) generation following viral infection which in the early phase of infection migrated to mitochondria to remove dysfunctional mitochondria through the process of mitophagy. DJ-1 was also observed to modulate the viral replication and interferon responses along with low-density lipoprotein (LDL) receptor expression in neurons. Collectively these evidences reveal a comprehensive role for DJ-1 in neurotropic virus infection in the brain.<\/jats:p>","DOI":"10.1038\/srep32593","type":"journal-article","created":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T11:01:11Z","timestamp":1472727671000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Network analysis reveals common host protein\/s modulating pathogenesis of neurotropic viruses"],"prefix":"10.1038","volume":"6","author":[{"given":"Sourish","family":"Ghosh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sriparna","family":"Mukherjee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nabonita","family":"Sengupta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arunava","family":"Roy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dhritiman","family":"Dey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Surajit","family":"Chakraborty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dhrubajyoti","family":"Chattopadhyay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arpan","family":"Banerjee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anirban","family":"Basu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,9,1]]},"reference":[{"key":"BFsrep32593_CR1","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.ijid.2014.02.011","volume":"24","author":"Y Zhang","year":"2014","unstructured":"Zhang, Y. et al. Antioxidants: potential antiviral agents for Japanese encephalitis virus infection. Int J Infect Dis 24, 30\u201336 (2014).","journal-title":"Int J Infect Dis"},{"key":"BFsrep32593_CR2","doi-asserted-by":"crossref","first-page":"e78425","DOI":"10.1371\/journal.pone.0078425","volume":"8","author":"J Fang","year":"2013","unstructured":"Fang, J. et al. Identification of three antiviral inhibitors against Japanese encephalitis virus from library of pharmacologically active compounds 1280. Plos One 8, e78425 (2013).","journal-title":"Plos One"},{"key":"BFsrep32593_CR3","doi-asserted-by":"crossref","first-page":"e8615","DOI":"10.1371\/journal.pone.0008615","volume":"5","author":"S Kumar","year":"2010","unstructured":"Kumar, S. & Arankalle, V. A. Intracranial administration of P gene siRNA protects mice from lethal Chandipura virus encephalitis. PLoS One 5, e8615 (2010).","journal-title":"PLoS One"},{"key":"BFsrep32593_CR4","doi-asserted-by":"crossref","first-page":"i57","DOI":"10.1093\/jac\/dkm159","volume":"60","author":"D Pillay","year":"2007","unstructured":"Pillay, D. The priorities for antiviral drug resistance surveillance and research. J Antimicrob Chemother 60 Suppl 1, i57\u2013i58 (2007).","journal-title":"J Antimicrob Chemother"},{"key":"BFsrep32593_CR5","first-page":"5","volume":"1","author":"D Pillay","year":"1998","unstructured":"Pillay, D. Emergence and control of resistance to antiviral drugs in resistance in herpes viruses, hepatitis B virus, and HIV. Commun Dis Public Health 1, 5\u201313 (1998).","journal-title":"Commun Dis Public Health"},{"key":"BFsrep32593_CR6","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1177\/135965359800300405","volume":"3","author":"D Pillay","year":"1998","unstructured":"Pillay, D. & Schinazi, R. F. Antiviral drug resistance: from the laboratory to the patient. Antivir Ther 3, 237 (1998).","journal-title":"Antivir Ther"},{"key":"BFsrep32593_CR7","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1136\/bmj.317.7159.660","volume":"317","author":"D Pillay","year":"1998","unstructured":"Pillay, D. & Zambon, M. Antiviral drug resistance. Bmj 317, 660\u2013662 (1998).","journal-title":"Bmj"},{"key":"BFsrep32593_CR8","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/j.chom.2015.09.009","volume":"18","author":"M Combe","year":"2015","unstructured":"Combe, M. et al. Single-Cell Analysis of RNA Virus Infection Identifies Multiple Genetically Diverse Viral Genomes within Single Infectious Units. Cell Host Microbe 18, 424\u2013432 (2015).","journal-title":"Cell Host Microbe"},{"key":"BFsrep32593_CR9","doi-asserted-by":"crossref","first-page":"2175","DOI":"10.1016\/S0140-6736(04)17579-X","volume":"364","author":"TJ John","year":"2004","unstructured":"John, T. J. Chandipura virus, encephalitis, and epidemic brain attack in India. Lancet 364, 2175; author reply 2175\u20132176 (2004).","journal-title":"Lancet"},{"key":"BFsrep32593_CR10","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1002\/hep.1840190406","volume":"19","author":"JC Wu","year":"1994","unstructured":"Wu, J. C. et al. Multiple viral infection as the most common cause of fulminant and subfulminant viral hepatitis in an area endemic for hepatitis B: application and limitations of the polymerase chain reaction. Hepatology 19, 836\u2013840 (1994).","journal-title":"Hepatology"},{"key":"BFsrep32593_CR11","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.tips.2013.11.006","volume":"35","author":"Z Lou","year":"2014","unstructured":"Lou, Z., Sun, Y. & Rao, Z. Current progress in antiviral strategies. Trends Pharmacol Sci 35, 86\u2013102 (2014).","journal-title":"Trends Pharmacol Sci"},{"key":"BFsrep32593_CR12","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1038\/nrmicro2655","volume":"9","author":"D Walsh","year":"2011","unstructured":"Walsh, D. & Mohr, I. Viral subversion of the host protein synthesis machinery. Nat Rev Microbiol 9, 860\u2013875 (2011).","journal-title":"Nat Rev Microbiol"},{"key":"BFsrep32593_CR13","doi-asserted-by":"crossref","first-page":"4311","DOI":"10.1021\/pr900491n","volume":"8","author":"L Zhang","year":"2009","unstructured":"Zhang, L. et al. Analysis of vaccinia virus-host protein-protein interactions: validations of yeast two-hybrid screenings. J Proteome Res 8, 4311\u20134318 (2009).","journal-title":"J Proteome Res"},{"key":"BFsrep32593_CR14","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.virol.2008.05.035","volume":"378","author":"JH Lee","year":"2008","unstructured":"Lee, J. H. et al. Identification of structural protein-protein interactions of herpes simplex virus type 1. Virology 378, 347\u2013354 (2008).","journal-title":"Virology"},{"key":"BFsrep32593_CR15","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/1752-0509-5-13","volume":"5","author":"V Navratil","year":"2015","unstructured":"Navratil, V., de Chassey, B., Combe, C. R. & Lotteau, V. When the human viral infectome and diseasome networks collide: towards a systems biology platform for the aetiology of human diseases. BMC Syst Biol 5, 13 (2015).","journal-title":"BMC Syst Biol"},{"key":"BFsrep32593_CR16","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1186\/1471-2105-10-73","volume":"10","author":"J Chen","year":"2009","unstructured":"Chen, J., Aronow, B. J. & Jegga, A. G. Disease candidate gene identification and prioritization using protein interaction networks. BMC Bioinformatics 10, 73 (2009).","journal-title":"BMC Bioinformatics"},{"key":"BFsrep32593_CR17","doi-asserted-by":"crossref","first-page":"14438","DOI":"10.1038\/srep14438","volume":"5","author":"S Ghosh","year":"2015","unstructured":"Ghosh, S., Kumar, G. V., Basu, A. & Banerjee, A. Graph theoretic network analysis reveals protein pathways underlying cell death following neurotropic viral infection. Sci Rep 5, 14438 (2015).","journal-title":"Sci Rep"},{"key":"BFsrep32593_CR18","doi-asserted-by":"crossref","first-page":"531","DOI":"10.4161\/auto.7.5.14684","volume":"7","author":"MK McCoy","year":"2011","unstructured":"McCoy, M. K. & Cookson, M. R. DJ-1 regulation of mitochondrial function and autophagy through oxidative stress. Autophagy 7, 531\u2013532 (2011).","journal-title":"Autophagy"},{"key":"BFsrep32593_CR19","doi-asserted-by":"crossref","first-page":"4888","DOI":"10.1093\/hmg\/dds325","volume":"21","author":"AP Joselin","year":"2012","unstructured":"Joselin, A. P. et al. ROS-dependent regulation of Parkin and DJ-1 localization during oxidative stress in neurons. Hum Mol Genet 21, 4888\u20134903 (2012).","journal-title":"Hum Mol Genet"},{"key":"BFsrep32593_CR20","doi-asserted-by":"crossref","first-page":"683920","DOI":"10.1155\/2013\/683920","volume":"2013","author":"H Ariga","year":"2013","unstructured":"Ariga, H. et al. Neuroprotective function of DJ-1 in Parkinson\u2019s disease. Oxid Med Cell Longev 2013, 683920 (2013).","journal-title":"Oxid Med Cell Longev"},{"key":"BFsrep32593_CR21","doi-asserted-by":"crossref","first-page":"e38144","DOI":"10.1371\/journal.pone.0038144","volume":"7","author":"S Yamaguchi","year":"2012","unstructured":"Yamaguchi, S. et al. Transcriptional activation of low-density lipoprotein receptor gene by DJ-1 and effect of DJ-1 on cholesterol homeostasis. PLoS One 7, e38144 (2012).","journal-title":"PLoS One"},{"key":"BFsrep32593_CR22","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1111\/jnc.13208","volume":"135","author":"S Ghosh","year":"2015","unstructured":"Ghosh, S., Mukherjee, S. & Basu, A. Chandipura virus perturbs cholesterol homeostasis leading to neuronal apoptosis. J Neurochem 135, 368\u2013380 (2015).","journal-title":"J Neurochem"},{"key":"BFsrep32593_CR23","doi-asserted-by":"crossref","first-page":"10887","DOI":"10.1074\/jbc.M113.535112","volume":"289","author":"S Girotto","year":"2014","unstructured":"Girotto, S. et al. DJ-1 is a copper chaperone acting on SOD1 activation. J Biol Chem 289, 10887\u201310899 (2014).","journal-title":"J Biol Chem"},{"key":"BFsrep32593_CR24","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1002\/ana.22514","volume":"70","author":"Z Wang","year":"2011","unstructured":"Wang, Z. et al. DJ-1 modulates the expression of Cu\/Zn-superoxide dismutase-1 through the Erk1\/2-Elk1 pathway in neuroprotection. Ann Neurol. 70, 591\u2013599 (2011).","journal-title":"Ann Neurol."},{"key":"BFsrep32593_CR25","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.1242\/jcs.063222","volume":"123","author":"XM Xu","year":"2010","unstructured":"Xu, X. M. et al. The Arabidopsis DJ-1a protein confers stress protection through cytosolic SOD activation. J Cell Sci. 123, 1644\u20131651 (2010).","journal-title":"J Cell Sci"},{"key":"BFsrep32593_CR26","first-page":"735618","volume":"2014","author":"J Tang","year":"2014","unstructured":"Tang, J. et al. PRAK interacts with DJ-1 and prevents oxidative stress-induced cell death. Oxid Med Cell Longev 2014, 735618 (2014).","journal-title":"Oxid Med Cell Longev"},{"key":"BFsrep32593_CR27","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1038\/nchembio.304","volume":"6","author":"T Schneider-Poetsch","year":"2010","unstructured":"Schneider-Poetsch, T. et al. Inhibition of eukaryotic translation elongation by cycloheximide and lactimidomycin. Nat Chem Biol 6, 209\u2013217 (2010).","journal-title":"Nat Chem Biol"},{"key":"BFsrep32593_CR28","doi-asserted-by":"crossref","first-page":"3024","DOI":"10.1128\/MCB.00286-14","volume":"34","author":"B Bjorkblom","year":"2014","unstructured":"Bjorkblom, B. et al. Reactive oxygen species-mediated DJ-1 monomerization modulates intracellular trafficking involving karyopherin beta2. Mol Cell Biol 34, 3024\u20133040 (2014).","journal-title":"Mol Cell Biol"},{"key":"BFsrep32593_CR29","doi-asserted-by":"crossref","first-page":"3734","DOI":"10.1093\/hmg\/ddq288","volume":"19","author":"I Irrcher","year":"2010","unstructured":"Irrcher, I. et al. Loss of the Parkinson\u2019s disease-linked gene DJ-1 perturbs mitochondrial dynamics. Hum Mol Genet 19, 3734\u20133746 (2010).","journal-title":"Hum Mol Genet"},{"key":"BFsrep32593_CR30","doi-asserted-by":"crossref","first-page":"38","DOI":"10.3389\/fneur.2013.00038","volume":"4","author":"JF Trempe","year":"2013","unstructured":"Trempe, J. F. & Fon, E. A. Structure and Function of Parkin, PINK1, and DJ-1, the Three Musketeers of Neuroprotection. Front Neurol 4, 38 (2013).","journal-title":"Front Neurol"},{"key":"BFsrep32593_CR31","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.4161\/auto.21376","volume":"8","author":"G Chen","year":"2012","unstructured":"Chen, G. et al. Autophagy is a protective response to ethanol neurotoxicity. Autophagy 8, 1577\u20131589 (2012).","journal-title":"Autophagy"},{"key":"BFsrep32593_CR32","doi-asserted-by":"crossref","unstructured":"Joshi, D. C. & Bakowska, J. C. Determination of mitochondrial membrane potential and reactive oxygen species in live rat cortical neurons. J Vis Exp (2011).","DOI":"10.3791\/2704"},{"key":"BFsrep32593_CR33","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.bbrc.2007.04.106","volume":"358","author":"P Mukhopadhyay","year":"2007","unstructured":"Mukhopadhyay, P. et al. Simple quantitative detection of mitochondrial superoxide production in live cells. Biochem Biophys Res Commun 358, 203\u2013208 (2007).","journal-title":"Biochem Biophys Res Commun"},{"key":"BFsrep32593_CR34","doi-asserted-by":"crossref","first-page":"7673","DOI":"10.1128\/JVI.79.12.7673-7681.2005","volume":"79","author":"K Brzozka","year":"2005","unstructured":"Brzozka, K., Finke, S. & Conzelmann, K. K. Identification of the rabies virus alpha\/beta interferon antagonist: phosphoprotein P interferes with phosphorylation of interferon regulatory factor 3. J Virol 79, 7673\u20137681 (2005).","journal-title":"J Virol"},{"key":"BFsrep32593_CR35","doi-asserted-by":"crossref","first-page":"12398","DOI":"10.1128\/JVI.01864-13","volume":"87","author":"S Ghosh","year":"2013","unstructured":"Ghosh, S., Dutta, K. & Basu, A. Chandipura virus induces neuronal death through Fas-mediated extrinsic apoptotic pathway. J Virol 87, 12398\u201312406 (2013).","journal-title":"J Virol"},{"key":"BFsrep32593_CR36","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1111\/j.1471-4159.2008.05238.x","volume":"105","author":"MK Mishra","year":"2008","unstructured":"Mishra, M. K. & Basu, A. Minocycline neuroprotects, reduces microglial activation, inhibits caspase 3 induction, and viral replication following Japanese encephalitis. J Neurochem 105, 1582\u20131595 (2008).","journal-title":"J Neurochem"},{"key":"BFsrep32593_CR37","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1002\/biot.201000080","volume":"5","author":"ND Maynard","year":"2011","unstructured":"Maynard, N. D., Gutschow, M. V., Birch, E. W. & Covert, M. W. The virus as metabolic engineer. Biotechnol J 5, 686\u2013694 (2011).","journal-title":"Biotechnol J"},{"key":"BFsrep32593_CR38","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1038\/nrmicro2692","volume":"10","author":"PD Nagy","year":"2012","unstructured":"Nagy, P. D. & Pogany, J. The dependence of viral RNA replication on co-opted host factors. Nat Rev Microbiol 10, 137\u2013149 (2012).","journal-title":"Nat Rev Microbiol"},{"key":"BFsrep32593_CR39","first-page":"428570","volume":"2014","author":"M Altaf-Ul-Amin","year":"2014","unstructured":"Altaf-Ul-Amin, M., Afendi, F. M., Kiboi, S. K. & Kanaya, S. Systems biology in the context of big data and networks. Biomed Res Int 2014, 428570 (2014).","journal-title":"Biomed Res Int"},{"key":"BFsrep32593_CR40","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1186\/s40169-015-0061-6","volume":"4","author":"T Melak","year":"2015","unstructured":"Melak, T. & Gakkhar, S. Maximum flow approach to prioritize potential drug targets of Mycobacterium tuberculosis H37Rv from protein-protein interaction network. Clin Transl Med 4, 61 (2015).","journal-title":"Clin Transl Med"},{"key":"BFsrep32593_CR41","doi-asserted-by":"crossref","first-page":"10816","DOI":"10.1074\/jbc.M509079200","volume":"281","author":"J Choi","year":"2006","unstructured":"Choi, J. et al. Oxidative damage of DJ-1 is linked to sporadic Parkinson and Alzheimer diseases. J Biol Chem 281, 10816\u201310824 (2006).","journal-title":"J Biol Chem"},{"key":"BFsrep32593_CR42","first-page":"467452","volume":"2014","author":"ML Reshi","year":"2012","unstructured":"Reshi, M. L., Su, Y. C. & Hong, J. R. RNA Viruses: ROS-Mediated Cell Death. Int J Cell Biol 2014, 467452 (2012).","journal-title":"Int J Cell Biol"},{"key":"BFsrep32593_CR43","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/290457a0","volume":"290","author":"S Anderson","year":"1981","unstructured":"Anderson, S. et al. Sequence and organization of the human mitochondrial genome. Nature 290, 457\u2013465 (1981).","journal-title":"Nature"},{"key":"BFsrep32593_CR44","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1002\/biof.5520060404","volume":"6","author":"E Cadenas","year":"1997","unstructured":"Cadenas, E. Basic mechanisms of antioxidant activity. Biofactors 6, 391\u2013397 (1997).","journal-title":"Biofactors"},{"key":"BFsrep32593_CR45","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1186\/1750-1326-6-48","volume":"6","author":"Y Kitamura","year":"2011","unstructured":"Kitamura, Y. et al. Neuroprotective effect of a new DJ-1-binding compound against neurodegeneration in Parkinson\u2019s disease and stroke model rats. Mol Neurodegener 6, 48 (2011).","journal-title":"Mol Neurodegener"},{"key":"BFsrep32593_CR46","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/j.redox.2014.04.010","volume":"2","author":"P Lopert","year":"2014","unstructured":"Lopert, P. & Patel, M. Brain mitochondria from DJ-1 knockout mice show increased respiration-dependent hydrogen peroxide consumption. Redox Biol 2, 667\u2013672 (2014).","journal-title":"Redox Biol"},{"key":"BFsrep32593_CR47","doi-asserted-by":"crossref","first-page":"7415","DOI":"10.1038\/ncomms8415","volume":"6","author":"SY Shi","year":"2014","unstructured":"Shi, S. Y. et al. DJ-1 links muscle ROS production with metabolic reprogramming and systemic energy homeostasis in mice. Nat Commun 6, 7415 (2014).","journal-title":"Nat Commun"},{"key":"BFsrep32593_CR48","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1186\/1743-422X-5-121","volume":"5","author":"A Balakrishnan","year":"2008","unstructured":"Balakrishnan, A. & Mishra, A. C. Immune response during acute Chandipura viral infection in experimentally infected susceptible mice. Virol J 5, 121 (2008).","journal-title":"Virol J"},{"key":"BFsrep32593_CR49","doi-asserted-by":"crossref","first-page":"e8134","DOI":"10.1371\/journal.pone.0008134","volume":"4","author":"S Das","year":"2009","unstructured":"Das, S., Ghosh, D. & Basu, A. Japanese encephalitis virus induce immuno-competency in neural stem\/progenitor cells. PLoS One 4, e8134 (2009).","journal-title":"PLoS One"},{"key":"BFsrep32593_CR50","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.neulet.2004.10.088","volume":"374","author":"DW Miller","year":"2005","unstructured":"Miller, D. W. et al. Identification of the epitope of a monoclonal antibody to DJ-1. Neurosci Lett 374, 203\u2013206 (2005).","journal-title":"Neurosci Lett"},{"key":"BFsrep32593_CR51","doi-asserted-by":"crossref","first-page":"3957","DOI":"10.1128\/IAI.00374-10","volume":"78","author":"N Sengupta","year":"2010","unstructured":"Sengupta, N. et al. Comparative proteomic analysis of extracellular proteins of Clostridium perfringens type A and type C strains. Infect Immun 78, 3957\u20133968 (2010).","journal-title":"Infect Immun"},{"key":"BFsrep32593_CR52","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/S0076-6879(84)04093-3","volume":"104","author":"PJ Blackshear","year":"1984","unstructured":"Blackshear, P. J. Systems for polyacrylamide gel electrophoresis. Methods Enzymol 104, 237\u2013255 (1984).","journal-title":"Methods Enzymol"},{"key":"BFsrep32593_CR53","unstructured":"Dai, D. & Huiguang, H. VisualConnectome: Toolbox for brain network visualization and analysis (Abstract). Human Brain Mapping (2011)."},{"key":"BFsrep32593_CR54","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/j.neuint.2009.01.022","volume":"54","author":"MK Mishra","year":"2009","unstructured":"Mishra, M. K., Ghosh, D., Duseja, R. & Basu, A. Antioxidant potential of Minocycline in Japanese Encephalitis Virus infection in murine neuroblastoma cells: correlation with membrane fluidity and cell death. Neurochem Int 54, 464\u2013470 (2009).","journal-title":"Neurochem Int"},{"key":"BFsrep32593_CR55","doi-asserted-by":"crossref","first-page":"13129","DOI":"10.1073\/pnas.0506716102","volume":"102","author":"AB Castoreno","year":"2005","unstructured":"Castoreno, A. B. et al. Transcriptional regulation of phagocytosis-induced membrane biogenesis by sterol regulatory element binding proteins. Proc Natl Acad Sci USA 102, 13129\u201313134 (2005).","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFsrep32593_CR56","doi-asserted-by":"crossref","first-page":"E128","DOI":"10.1152\/ajpendo.00400.2003","volume":"287","author":"N Sekar","year":"2004","unstructured":"Sekar, N. & Veldhuis, J. D. Involvement of Sp1 and SREBP-1a in transcriptional activation of the LDLR gene by insulin and LH in cultured porcine granulosa-luteal cells. Am J Physiol Endocrinol Metab 287, E128\u2013E135 (2004).","journal-title":"Am J Physiol Endocrinol Metab"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/srep32593.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/srep32593","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/srep32593.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,4]],"date-time":"2023-01-04T23:50:03Z","timestamp":1672876203000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/srep32593"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9,1]]},"references-count":56,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2016,12,16]]}},"alternative-id":["BFsrep32593"],"URL":"https:\/\/doi.org\/10.1038\/srep32593","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,9,1]]},"assertion":[{"value":"20 June 2016","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 July 2016","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 September 2016","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing financial interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"32593"}}