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The pathogenesis of CD is not clearly understood and is probably attributed to genomic variations and host genetic make-up. Case-control and cohort studies of the association between the <jats:italic>TNF-\u03b1<\/jats:italic> -308 G\u2009&gt;\u2009A (rs1800629) polymorphism and CD susceptibility have yielded inconsistent results. In this study, PubMed, EMBASE, and Google Scholar web-databases were searched for pertinent reports showing association of <jats:italic>TNF-\u03b1<\/jats:italic> -308 G\u2009&gt;\u2009A gene with CD risk. A total of eleven reports involving 1774 controls and 1147 CD cases were included. Significant associations in four genetic models, <jats:italic>viz.<\/jats:italic> variant allele (A vs. G: p\u2009=\u20090.001; OR\u2009=\u20092.051, 95% CI\u2009=\u20091.452\u20132.895), variant homozygous (AA vs. GG: p\u2009=\u20090.001; OR\u2009=\u20096.626, 95% CI\u2009=\u20093.569\u201312.300), recessive (AA vs. GG\u2009+\u2009AG: p\u2009=\u20090.001; OR\u2009=\u20094.766, 95% CI\u2009=\u20093.177\u20137.152) and dominant (AA\u2009+\u2009AG vs. GG: p\u2009=\u20090.008; OR\u2009=\u20091.910, 95% CI\u2009=\u20091.181\u20133.088) were found in comparison with wild type homozygous GG genotype. However, heterozygous genetic model did not show any association. Sensitivity analysis revealed stable and statistically robust results. Our results suggest that <jats:italic>TNF-\u03b1<\/jats:italic> -308 G\u2009&gt;\u2009A gene polymorphism significantly contributes to CD susceptibility.<\/jats:p>","DOI":"10.1038\/srep32677","type":"journal-article","created":{"date-parts":[[2016,9,6]],"date-time":"2016-09-06T09:25:47Z","timestamp":1473153947000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["TNF-\u03b1 -308 G\u2009&gt;\u2009A (rs1800629) Polymorphism is Associated with Celiac Disease: A Meta-analysis of 11 Case-Control Studies"],"prefix":"10.1038","volume":"6","author":[{"given":"Saif","family":"Khan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raju K.","family":"Mandal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arshad","family":"Jawed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sajad A.","family":"Dar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohd","family":"Wahid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aditya K.","family":"Panda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed Y.","family":"Areeshi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md. 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