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Since few of these precancers progress to cancers; it is worth to identify biological molecules that may play important roles in progression. Here, expression deregulation of 7 miRNAs (<jats:italic>mir204, mir31, mir31*, mir133a, mir7, mir206<\/jats:italic> and <jats:italic>mir1293<\/jats:italic>) and their possible target genes in 23 cancers, 18 LK, 12 LP, 23 OSMF tissues compared to 20 healthy tissues was determined by qPCR method. Expression of <jats:italic>mir7, mir31, mir31*<\/jats:italic> and <jats:italic>mir1293<\/jats:italic> was upregulated and that of <jats:italic>mir133a, mir204<\/jats:italic> and <jats:italic>mir206<\/jats:italic> was downregulated in cancer. Expression of most of these miRNAs was also upregulated in LK and LP tissues but not in OSMF. Expression deregulation of some of the target genes was also determined in cancer, LK and LP tissues. Significant upregulation of <jats:italic>mir31<\/jats:italic> and downregulation of its target gene, <jats:italic>CXCL12<\/jats:italic>, in cancer, LK and LP tissues suggest their importance in progression of precancer to cancer. Expression upregulation of <jats:italic>mir31<\/jats:italic> was also validated using <jats:italic>GEO<\/jats:italic> data sets. Although sample size is low, novelty of this work lies in studying expression deregulation of miRNAs and target genes in oral cancer and three types of precancerous lesions.<\/jats:p>","DOI":"10.1038\/srep32735","type":"journal-article","created":{"date-parts":[[2016,9,6]],"date-time":"2016-09-06T09:37:20Z","timestamp":1473154640000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Expression deregulation of mir31 and CXCL12 in two types of oral precancers and cancer: importance in progression of precancer and cancer"],"prefix":"10.1038","volume":"6","author":[{"given":"Esita","family":"Chattopadhyay","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richa","family":"Singh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anindita","family":"Ray","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roshni","family":"Roy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Navonil","family":"De Sarkar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ranjan Rashmi","family":"Paul","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mousumi","family":"Pal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ritesh","family":"Aich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bidyut","family":"Roy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2016,9,6]]},"reference":[{"key":"BFsrep32735_CR1","doi-asserted-by":"publisher","first-page":"2999","DOI":"10.1073\/pnas.0307323101","volume":"101","author":"GA Calin","year":"2004","unstructured":"Calin, G. 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