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We investigated 9 loci involved in different immune functions (<jats:italic>ADAM33<\/jats:italic>, <jats:italic>ADRB2<\/jats:italic>, <jats:italic>CD14, IL13<\/jats:italic>, <jats:italic>IL4<\/jats:italic>, <jats:italic>IL4R<\/jats:italic>, <jats:italic>MS4A2<\/jats:italic>, <jats:italic>SERPINE1<\/jats:italic>, and <jats:italic>TNF<\/jats:italic>) with respect to 116 traits assessed through blood tests, hypertonic saline challenge tests, questionnaires, and skin prick tests. Multiple associations were observed for <jats:italic>ADAM33<\/jats:italic>: rs2280090 was associated with reduced MEF240% (i.e., the ratio of Mean Expiratory Flow after 240s of hypertonic saline inhalation with respect to the age- and ancestry-matched reference value) and with an increased risk of allergic bronchitis (p\u2009=\u20091.77*10<jats:sup>\u22124<\/jats:sup> and p\u2009=\u20097.94*10<jats:sup>\u22124<\/jats:sup>, respectively); rs3918396 was associated with wheezing and eczema comorbidity (p\u2009=\u20093.41*10<jats:sup>\u22124<\/jats:sup>). <jats:italic>IL4<\/jats:italic> rs2243250 was associated with increased FEV240 (Forced Expiratory Flow Volume after 240s of hypertonic saline inhalation; p\u2009=\u20094.81*10<jats:sup>\u22124<\/jats:sup>) and <jats:italic>CD14<\/jats:italic> rs2569190 was associated with asthma diagnosis (p\u2009=\u20091.36*10<jats:sup>\u22123<\/jats:sup>). <jats:italic>ADAM33<\/jats:italic> and <jats:italic>IL4<\/jats:italic> appeared to play a role in the processes linked to allergic airway inflammation and lung function. Due to its association with wheezing and eczema comorbidity, <jats:italic>ADAM33<\/jats:italic> may also be involved in the atopic march.<\/jats:p>","DOI":"10.1038\/srep33152","type":"journal-article","created":{"date-parts":[[2016,9,14]],"date-time":"2016-09-14T08:01:22Z","timestamp":1473840082000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Allergy-specific Phenome-Wide Association Study for Immunogenes in Turkish Children"],"prefix":"10.1038","volume":"6","author":[{"given":"Sefayet","family":"Karaca","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ersoy","family":"Civelek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehmet","family":"Karaca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Umit M.","family":"Sahiner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Riza K.","family":"Ozgul","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Can N.","family":"Kocabas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renato","family":"Polimanti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B\u00fclent E.","family":"Sekerel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2016,9,14]]},"reference":[{"key":"BFsrep33152_CR1","doi-asserted-by":"publisher","first-page":"1211","DOI":"10.1056\/NEJMoa0906312","volume":"363","author":"MF Moffatt","year":"2010","unstructured":"Moffatt, M. 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