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Emerging evidence indicates that OPTN mutation is involved in accumulation of damaged mitochondria and defective mitophagy. Nevertheless, the role played by an OPTN E50K mutation in the pathogenic mitochondrial mechanism that underlies retinal ganglion cell (RGC) degeneration in POAG remains unknown. We show here that E50K expression induces mitochondrial fission-mediated mitochondrial degradation and mitophagy in the axons of the glial lamina of aged E50K\n                    <jats:sup>\u2212tg<\/jats:sup>\n                    mice\n                    <jats:italic>in vivo<\/jats:italic>\n                    . While E50K activates the Bax pathway and oxidative stress, and triggers dynamics alteration-mediated mitochondrial degradation and mitophagy in RGC somas\n                    <jats:italic>in vitro<\/jats:italic>\n                    , it does not affect transport dynamics and fission of mitochondria in RGC axons\n                    <jats:italic>in vitro<\/jats:italic>\n                    . These results strongly suggest that E50K is associated with mitochondrial dysfunction in RGC degeneration in synergy with environmental factors such as aging and\/or oxidative stress.\n                  <\/jats:p>","DOI":"10.1038\/srep33830","type":"journal-article","created":{"date-parts":[[2016,9,22]],"date-time":"2016-09-22T05:00:33Z","timestamp":1474520433000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":72,"title":["Mitochondrial pathogenic mechanism and degradation in optineurin E50K mutation-mediated retinal ganglion cell degeneration"],"prefix":"10.1038","volume":"6","author":[{"given":"Myoung Sup","family":"Shim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuji","family":"Takihara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keun-Young","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Iwata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatrice Y. 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