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It is assumed that it is most important to treat thick AKs as they are believed to be more dysplastic than thin AKs. However, a relation between AK thickness and dysplasia or the expression of p53 has never been demonstrated. The aim of this study was to investigate this possible relation. Sixty-six AKs were included for clinical and histological examination. Prior to performing a punch biopsy, the clinical thickness of each AK was measured objectively using two scale bars with a thickness of 0.5\u2009mm and 1\u2009mm. Subsequently, the thickness of the epidermis, the severity of dysplasia and the expression of p53 were assessed histologically. We found a strong and significant positive correlation between measured clinical thickness of the AKs and the histological thickness of epidermis (p\u2009&lt;\u20090.0001). However, the clinical thickness did not correlate with either the severity of dysplasia (p\u2009=\u20090.7) or the expression of p53 (p\u2009=\u20090.5). In conclusion, thin AKs show the same severity of dysplasia and expression of p53 as thicker AK lesions. Consequently, clinical thickness cannot predict aggressiveness.<\/jats:p>","DOI":"10.1038\/srep33952","type":"journal-article","created":{"date-parts":[[2016,9,27]],"date-time":"2016-09-27T09:27:56Z","timestamp":1474968476000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Thickness of Actinic Keratosis Does Not Predict Dysplasia Severity or P53 Expression"],"prefix":"10.1038","volume":"6","author":[{"given":"Ida M.","family":"Heerfordt","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoffer V.","family":"Nissen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Poulsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter A.","family":"Philipsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans Christian","family":"Wulf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,9,27]]},"reference":[{"key":"BFsrep33952_CR1","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1172\/JCI57415","volume":"122","author":"V Ratushny","year":"2012","unstructured":"Ratushny, V., Gober, M. 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