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To address this problem, the study was to investigate the influence of histone acetylation on SOD1 expression and its effects in the pathogenesis of senile cataract. Senile cataract was classified into three types\u2014nuclear cataract (NC), cortical cataract (CC), and posterior subcapsular cataract (SC)\u2014using the Lens Opacities Classification System III. In senile cataracts, SOD1 expression decreased significantly. Both H3 and H4 were deacetylated at \u2212600\u2009bp of the SOD1 promoter of cataract lenses, and hypoacetylated at \u22121500, \u22121200, and \u2212900\u2009bp. In hypoacetylated histones, the hypoacetylation pattern differed among the cataracts. <jats:italic>In vitro<\/jats:italic>, anacardic acid (AA) significantly reduced H3 and H4 acetylation at the SOD1 promoter, decreased protein expression, and induced cataract formation in rabbits. AA also inhibited HLEC viability and increased cell apoptosis. In contrast, trichostatin A (TSA) was able to efficaciously stop AA\u2019s effects on both rabbit lenses and HLECs. Decreased histone acetylation at the SOD1 promoter is associated with declined SOD1 expression in senile cataracts. Histone acetylation plays an essential role in the regulation of SOD1 expression and in the pathogenesis of senile cataracts.<\/jats:p>","DOI":"10.1038\/srep34704","type":"journal-article","created":{"date-parts":[[2016,10,5]],"date-time":"2016-10-05T09:34:20Z","timestamp":1475660060000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Effects of histone acetylation on superoxide dismutase 1 gene expression in the pathogenesis of senile cataract"],"prefix":"10.1038","volume":"6","author":[{"given":"Xianfang","family":"Rong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaodi","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongxiang","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinglei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,10,5]]},"reference":[{"key":"BFsrep34704_CR1","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1097\/ICU.0b013e3283414fc8","volume":"22","author":"GN Rao","year":"2011","unstructured":"Rao, G. 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