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CEUS characteristics were analysed including the enhancement patterns, peak intensity, homogeneity of enhancement, and pseudocapsule. Quantitative parameters of peak intensity (P) and time to peak (TP) were measured with QontraXt software, and the index \u201crelative enhancement percentage\u201d \u0394P% and \u201cdifference in TP between tumor and cortex\u201d \u0394TP were used to quantify the CEUS features of renal tumors. There are significant difference in CEUS features between the 46 clear cell renal cell carcinoma (CCRCC) and other types of renal tumors, including 17 low malignant lesions, 11 urothelial carcinoma of the renal pelvis, and 19 renal angiomyolipoma. The differences lie in the peak intensity, the homogeneity, the time of wash-in, peak, clearance and presence of pseudocapsule. The \u0394TP and \u0394P% of the CCRCC is significantly different from other tumors. With \u201cfast to peak\u2009+\u2009high peak intensity\u201d as the main criterion, assisted with \u201cheterogeneous enhancement\u201d and \u201cfast wash-in\u201d as the secondary criteria, the diagnostic accuracy of CCRCC is 91.4%, demonstrating quantitative CEUS imaging is highly valuable in differentiating CCRCC from other tumors.<\/jats:p>","DOI":"10.1038\/srep35081","type":"journal-article","created":{"date-parts":[[2016,10,11]],"date-time":"2016-10-11T05:38:00Z","timestamp":1476164280000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["Contrast-Enhanced Ultrasonography with Quantitative Analysis allows Differentiation of Renal Tumor Histotypes"],"prefix":"10.1038","volume":"6","author":[{"given":"Di","family":"Sun","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cong","family":"Wei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qijie","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bing","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2016,10,11]]},"reference":[{"key":"BFsrep35081_CR1","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1148\/radiology.201.1.8816543","volume":"201","author":"JA Buckley","year":"1996","unstructured":"Buckley, J. 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