{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T08:18:29Z","timestamp":1769242709448,"version":"3.49.0"},"reference-count":57,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2016,10,14]],"date-time":"2016-10-14T00:00:00Z","timestamp":1476403200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2016,10,14]],"date-time":"2016-10-14T00:00:00Z","timestamp":1476403200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Several studies have been conducted to check the prevalence of methicillin-resistant strains of <jats:italic>Staphylococcus aureus<\/jats:italic> (MRSA) in animals and animal-derived food products but limited data are available regarding their virulence and associated gene expression profile. In the present study, antibiotic resistance and virulence of MRSA and methicillin-sensitive <jats:italic>S. aureus<\/jats:italic> animal isolates were determined <jats:italic>in vitro<\/jats:italic> by agar dilution, biofilm formation, adhesion, invasion and intracellular survivability assays. In addition, the pathogenicity of these isolates was examined in a murine model of <jats:italic>S. aureus<\/jats:italic> sepsis. MRSA1679a, a strain isolated from chicken, was observed to be highly virulent, in cell culture and in mouse model, and exhibited extensive resistant profile. Comparative gene expression profile of MRSA1679a and the reference human MRSA strain (ATCC 29213) was performed using Illumina-based transcriptome and RT-qPCR analyses. Several virulence elements including 22 toxin genes were detected in MRSA animal-isolate. In addition, we observed enhanced expression of crucial virulence regulators, such as <jats:italic>sarA<\/jats:italic> and <jats:italic>KdpDE<\/jats:italic> in MRSA animal-isolate compared to the human isolate. Collectively, gene expression profile including several virulence and drug-resistance factors confirmed the unique and highly virulent determinants of the MRSA strain of poultry origin which warrants further attention due to significant threat to public health.<\/jats:p>","DOI":"10.1038\/srep35442","type":"journal-article","created":{"date-parts":[[2016,10,14]],"date-time":"2016-10-14T10:29:51Z","timestamp":1476440991000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Comparative virulence studies and transcriptome analysis of Staphylococcus aureus strains isolated from animals"],"prefix":"10.1038","volume":"6","author":[{"given":"Zahid","family":"Iqbal","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed N.","family":"Seleem","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hafiz Iftikhar","family":"Hussain","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lingli","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haihong","family":"Hao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zonghui","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2016,10,14]]},"reference":[{"key":"BFsrep35442_CR1","doi-asserted-by":"crossref","unstructured":"K\u00f6ck, R. et al. Methicillin-resistant Staphylococcus aureus (MRSA): burden of disease and control challenges in Europe. (2010).","DOI":"10.3238\/arztebl.2011.0761"},{"key":"BFsrep35442_CR2","doi-asserted-by":"publisher","first-page":"630","DOI":"10.1016\/j.ijmm.2011.09.004","volume":"301","author":"H Graveland","year":"2011","unstructured":"Graveland, H., Duim, B., Van Duijkeren, E., Heederik, D. & Wagenaar, J. A. Livestock-associated methicillin-resistant Staphylococcus aureus in animals and humans. International Journal of Medical Microbiology 301, 630\u2013634 (2011).","journal-title":"International Journal of Medical Microbiology"},{"key":"BFsrep35442_CR3","doi-asserted-by":"publisher","first-page":"e0151956","DOI":"10.1371\/journal.pone.0151956","volume":"11","author":"O Simonetti","year":"2016","unstructured":"Simonetti, O. et al. Efficacy of the Quorum Sensing Inhibitor FS10 Alone and in Combination with Tigecycline in an Animal Model of Staphylococcal Infected Wound. PloS one 11, e0151956 (2016).","journal-title":"PloS one"},{"key":"BFsrep35442_CR4","doi-asserted-by":"publisher","first-page":"e96308","DOI":"10.1371\/journal.pone.0096308","volume":"9","author":"B Vossenkuhl","year":"2014","unstructured":"Vossenkuhl, B. et al. Comparison of spa Types, SCC mec Types and Antimicrobial Resistance Profiles of MRSA Isolated from Turkeys at Farm, Slaughter and from Retail Meat Indicates Transmission along the Production Chain. PloS one 9, e96308 (2014).","journal-title":"PloS one"},{"key":"BFsrep35442_CR5","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1111\/j.1469-0691.2012.03846.x","volume":"18","author":"A Fluit","year":"2012","unstructured":"Fluit, A. Livestock\u2010associated Staphylococcus aureus. Clinical Microbiology and Infection 18, 735\u2013744 (2012).","journal-title":"Clinical Microbiology and Infection"},{"key":"BFsrep35442_CR6","doi-asserted-by":"publisher","first-page":"5486","DOI":"10.1128\/JB.187.15.5486-5492.2005","volume":"187","author":"X Liang","year":"2005","unstructured":"Liang, X. et al. Global regulation of gene expression by ArlRS, a two-component signal transduction regulatory system of Staphylococcus aureus. Journal of bacteriology 187, 5486\u20135492 (2005).","journal-title":"Journal of bacteriology"},{"key":"BFsrep35442_CR7","doi-asserted-by":"crossref","first-page":"6232","DOI":"10.1128\/JB.180.23.6232-6241.1998","volume":"180","author":"PF Chan","year":"1998","unstructured":"Chan, P. F. & Foster, S. J. Role of SarA in virulence determinant production and environmental signal transduction in Staphylococcus aureus. Journal of Bacteriology 180, 6232\u20136241 (1998).","journal-title":"Journal of Bacteriology"},{"key":"BFsrep35442_CR8","doi-asserted-by":"publisher","first-page":"2154","DOI":"10.1128\/IAI.01180-10","volume":"79","author":"T Xue","year":"2011","unstructured":"Xue, T., You, Y., Hong, D., Sun, H. & Sun, B. The Staphylococcus aureus KdpDE two-component system couples extracellular K+ sensing and Agr signaling to infection programming. Infection and immunity 79, 2154\u20132167 (2011).","journal-title":"Infection and immunity"},{"key":"BFsrep35442_CR9","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1016\/S1286-4579(01)01414-9","volume":"3","author":"RP Novick","year":"2001","unstructured":"Novick, R. P., Schlievert, P. & Ruzin, A. Pathogenicity and resistance islands of staphylococci. Microbes and infection 3, 585\u2013594 (2001).","journal-title":"Microbes and infection"},{"key":"BFsrep35442_CR10","doi-asserted-by":"crossref","unstructured":"Soni, I., Chakrapani, H. & Chopra, S. Draft Genome Sequence of Methicillin-Sensitive Staphylococcus aureus ATCC 29213. Genome Announc 3, 10.1128\/genomeA.01095-15 (2015).","DOI":"10.1128\/genomeA.01095-15"},{"key":"BFsrep35442_CR11","doi-asserted-by":"publisher","first-page":"1505","DOI":"10.1099\/mic.0.025544-0","volume":"155","author":"S Mart\u00ednez-Pulgar\u00edn","year":"2009","unstructured":"Mart\u00ednez-Pulgar\u00edn, S., Dominguez-Bernal, G., Orden, J. A. & de la Fuente, R. Simultaneous lack of catalase and beta-toxin in Staphylococcus aureus leads to increased intracellular survival in macrophages and epithelial cells and to attenuated virulence in murine and ovine models. Microbiology 155, 1505\u20131515 (2009).","journal-title":"Microbiology"},{"key":"BFsrep35442_CR12","doi-asserted-by":"publisher","first-page":"e40458","DOI":"10.1371\/journal.pone.0040458","volume":"7","author":"DM Jamrozy","year":"2012","unstructured":"Jamrozy, D. M., Fielder, M. D., Butaye, P. & Coldham, N. G. Comparative genotypic and phenotypic characterisation of methicillin-resistant Staphylococcus aureus ST398 isolated from animals and humans. PLoS One 7, e40458 (2012).","journal-title":"PLoS One"},{"key":"BFsrep35442_CR13","doi-asserted-by":"crossref","unstructured":"Witte, W., Strommenger, B., Stanek, C. & Cuny, C. Methicillin-resistant Staphylococcus aureus ST398 in humans and animals, Central Europe. (2007).","DOI":"10.3201\/eid1302.060924"},{"key":"BFsrep35442_CR14","doi-asserted-by":"publisher","first-page":"1296","DOI":"10.1128\/AEM.07260-11","volume":"78","author":"C Cuny","year":"2012","unstructured":"Cuny, C., Friedrich, A. W. & Witte, W. Absence of livestock-associated methicillin-resistant Staphylococcus aureus clonal complex CC398 as a nasal colonizer of pigs raised in an alternative system. Applied and environmental microbiology 78, 1296\u20131297 (2012).","journal-title":"Applied and environmental microbiology"},{"key":"BFsrep35442_CR15","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1016\/j.ijfoodmicro.2014.06.018","volume":"186","author":"B Kraushaar","year":"2014","unstructured":"Kraushaar, B. & Fetsch, A. First description of PVL-positive methicillin-resistant Staphylococcus aureus (MRSA) in wild boar meat. International journal of food microbiology 186, 68\u201373 (2014).","journal-title":"International journal of food microbiology"},{"key":"BFsrep35442_CR16","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1016\/j.ijmm.2013.12.003","volume":"304","author":"X Yan","year":"2014","unstructured":"Yan, X. et al. Staphylococcus aureus ST398 from slaughter pigs in northeast China. International Journal of Medical Microbiology 304, 379\u2013383 (2014).","journal-title":"International Journal of Medical Microbiology"},{"key":"BFsrep35442_CR17","doi-asserted-by":"publisher","first-page":"2426","DOI":"10.1128\/JB.187.7.2426-2438.2005","volume":"187","author":"SR Gill","year":"2005","unstructured":"Gill, S. R. et al. Insights on evolution of virulence and resistance from the complete genome analysis of an early methicillin-resistant Staphylococcus aureus strain and a biofilm-producing methicillin-resistant Staphylococcus epidermidis strain. Journal of bacteriology 187, 2426\u20132438 (2005).","journal-title":"Journal of bacteriology"},{"key":"BFsrep35442_CR18","doi-asserted-by":"publisher","first-page":"6148","DOI":"10.3390\/ijerph120606148","volume":"12","author":"LS Abdalrahman","year":"2015","unstructured":"Abdalrahman, L. S., Stanley, A., Wells, H. & Fakhr, M. K. Isolation, Virulence, and Antimicrobial Resistance of Methicillin-Resistant Staphylococcus aureus (MRSA) and Methicillin Sensitive Staphylococcus aureus (MSSA) Strains from Oklahoma Retail Poultry Meats. International journal of environmental research and public health 12, 6148\u20136161, 10.3390\/ijerph120606148 (2015).","journal-title":"International journal of environmental research and public health"},{"key":"BFsrep35442_CR19","doi-asserted-by":"crossref","unstructured":"Yang, Y. et al. A novel nitro-dexamethasone inhibits agr system activity and improves therapeutic effects in MRSA sepsis models without antibiotics. Scientific reports 6 (2016).","DOI":"10.1038\/srep20307"},{"key":"BFsrep35442_CR20","doi-asserted-by":"crossref","unstructured":"Tan, X. et al. Transcriptome analysis of the biofilm formed by methicillin-susceptible Staphylococcus aureus. Scientific reports 5 (2015).","DOI":"10.1038\/srep11997"},{"key":"BFsrep35442_CR21","doi-asserted-by":"crossref","unstructured":"Chu, M. et al. Role of Berberine in the Treatment of Methicillin-Resistant Staphylococcus aureus Infections. Scientific reports 6 (2016).","DOI":"10.1038\/srep24748"},{"key":"BFsrep35442_CR22","doi-asserted-by":"crossref","unstructured":"Qin, N. et al. RNA-Seq-based transcriptome analysis of methicillin-resistant Staphylococcus aureus biofilm inhibition by ursolic acid and resveratrol. Scientific reports 4 (2014).","DOI":"10.1038\/srep05467"},{"key":"BFsrep35442_CR23","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1471-2164-14-891","volume":"14","author":"AM Lewandowska-Sabat","year":"2013","unstructured":"Lewandowska-Sabat, A. M. et al. The early phase transcriptome of bovine monocyte-derived macrophages infected with Staphylococcus aureus in vitro. BMC genomics 14, 1 (2013).","journal-title":"BMC genomics"},{"key":"BFsrep35442_CR24","doi-asserted-by":"publisher","first-page":"816","DOI":"10.1038\/nm.2692","volume":"18","author":"M Li","year":"2012","unstructured":"Li, M. et al. MRSA epidemic linked to a quickly spreading colonization and virulence determinant. Nature medicine 18, 816\u2013819 (2012).","journal-title":"Nature medicine"},{"key":"BFsrep35442_CR25","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.tim.2008.11.005","volume":"17","author":"C Garzoni","year":"2009","unstructured":"Garzoni, C. & Kelley, W. L. Staphylococcus aureus: new evidence for intracellular persistence. Trends in microbiology 17, 59\u201365 (2009).","journal-title":"Trends in microbiology"},{"key":"BFsrep35442_CR26","doi-asserted-by":"publisher","first-page":"1429","DOI":"10.1046\/j.1365-2958.2003.03526.x","volume":"48","author":"RP Novick","year":"2003","unstructured":"Novick, R. P. Autoinduction and signal transduction in the regulation of staphylococcal virulence. Molecular microbiology 48, 1429\u20131449 (2003).","journal-title":"Molecular microbiology"},{"key":"BFsrep35442_CR27","doi-asserted-by":"publisher","first-page":"948","DOI":"10.1038\/nrmicro1289","volume":"3","author":"TJ Foster","year":"2005","unstructured":"Foster, T. J. Immune evasion by staphylococci. Nature Reviews Microbiology 3, 948\u2013958 (2005).","journal-title":"Nature Reviews Microbiology"},{"key":"BFsrep35442_CR28","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1126\/science.1188888","volume":"329","author":"MA Wyatt","year":"2010","unstructured":"Wyatt, M. A. et al. Staphylococcus aureus nonribosomal peptide secondary metabolites regulate virulence. Science 329, 294\u2013296 (2010).","journal-title":"Science"},{"key":"BFsrep35442_CR29","doi-asserted-by":"crossref","unstructured":"Le, K. Y. & Otto, M. Quorum-sensing regulation in staphylococci\u2014an overview. Frontiers in microbiology 6 (2015).","DOI":"10.3389\/fmicb.2015.01174"},{"key":"BFsrep35442_CR30","doi-asserted-by":"publisher","first-page":"669","DOI":"10.2217\/fmb.14.31","volume":"9","author":"R Singh","year":"2014","unstructured":"Singh, R. & Ray, P. Quorum sensing-mediated regulation of staphylococcal virulence and antibiotic resistance. Future microbiology 9, 669\u2013681 (2014).","journal-title":"Future microbiology"},{"key":"BFsrep35442_CR31","doi-asserted-by":"publisher","first-page":"3075","DOI":"10.1099\/mic.0.29033-0","volume":"152","author":"J Cassat","year":"2006","unstructured":"Cassat, J. et al. Transcriptional profiling of a Staphylococcus aureus clinical isolate and its isogenic agr and sarA mutants reveals global differences in comparison to the laboratory strain RN6390. Microbiology 152, 3075\u20133090 (2006).","journal-title":"Microbiology"},{"key":"BFsrep35442_CR32","doi-asserted-by":"publisher","first-page":"e01447","DOI":"10.1128\/mBio.01447-14","volume":"5","author":"A Kriegeskorte","year":"2014","unstructured":"Kriegeskorte, A. et al. Inactivation of thyA in Staphylococcus aureus attenuates virulence and has a strong impact on metabolism and virulence gene expression. Mbio 5, e01447\u201301414 (2014).","journal-title":"Mbio"},{"key":"BFsrep35442_CR33","doi-asserted-by":"publisher","first-page":"5267","DOI":"10.1128\/JB.186.16.5267-5280.2004","volume":"186","author":"AC Manna","year":"2004","unstructured":"Manna, A. C., Ingavale, S. S., Maloney, M., Van Wamel, W. & Cheung, A. L. Identification of sarV (SA2062), a new transcriptional regulator, is repressed by SarA and MgrA (SA0641) and involved in the regulation of autolysis in Staphylococcus aureus. Journal of bacteriology 186, 5267\u20135280 (2004).","journal-title":"Journal of bacteriology"},{"key":"BFsrep35442_CR34","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1038\/432811a","volume":"432","author":"J Barasch","year":"2004","unstructured":"Barasch, J. & Mori, K. Cell biology: iron thievery. Nature 432, 811\u2013813 (2004).","journal-title":"Nature"},{"key":"BFsrep35442_CR35","doi-asserted-by":"publisher","first-page":"946","DOI":"10.1038\/nrmicro1046","volume":"2","author":"UE Schaible","year":"2004","unstructured":"Schaible, U. E. & Kaufmann, S. H. Iron and microbial infection. Nature Reviews Microbiology 2, 946\u2013953 (2004).","journal-title":"Nature Reviews Microbiology"},{"key":"BFsrep35442_CR36","doi-asserted-by":"publisher","first-page":"3395","DOI":"10.1128\/IAI.00420-13","volume":"81","author":"TE Kehl-Fie","year":"2013","unstructured":"Kehl-Fie, T. E. et al. MntABC and MntH contribute to systemic Staphylococcus aureus infection by competing with calprotectin for nutrient manganese. Infection and immunity 81, 3395\u20133405 (2013).","journal-title":"Infection and immunity"},{"key":"BFsrep35442_CR37","doi-asserted-by":"publisher","first-page":"2818","DOI":"10.1128\/AAC.01704-10","volume":"55","author":"DS Jo","year":"2011","unstructured":"Jo, D. S., Montgomery, C. P., Yin, S., Boyle-Vavra, S. & Daum, R. S. Improved oxacillin treatment outcomes in experimental skin and lung infection by a methicillin-resistant Staphylococcus aureus isolate with a vraSR operon deletion. Antimicrobial agents and chemotherapy 55, 2818\u20132823 (2011).","journal-title":"Antimicrobial agents and chemotherapy"},{"key":"BFsrep35442_CR38","doi-asserted-by":"publisher","first-page":"e1002744","DOI":"10.1371\/journal.ppat.1002744","volume":"8","author":"K Schwartz","year":"2012","unstructured":"Schwartz, K., Syed, A. K., Stephenson, R. E., Rickard, A. H. & Boles, B. R. Functional amyloids composed of phenol soluble modulins stabilize Staphylococcus aureus biofilms. PLoS Pathog 8, e1002744 (2012).","journal-title":"PLoS Pathog"},{"key":"BFsrep35442_CR39","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/S0966-842X(02)00010-0","volume":"11","author":"KS McKeegan","year":"2003","unstructured":"McKeegan, K. S., Borges-Walmsley, M. I. & Walmsley, A. R. The structure and function of drug pumps: an update. Trends in microbiology 11, 21\u201329 (2003).","journal-title":"Trends in microbiology"},{"key":"BFsrep35442_CR40","doi-asserted-by":"crossref","unstructured":"Argudin, M. et al. Virulence and resistance determinants in German Staphylococcus aureus ST398 isolates from non-human origin. Applied and environmental microbiology (2011).","DOI":"10.1128\/AEM.02260-10"},{"key":"BFsrep35442_CR41","doi-asserted-by":"publisher","first-page":"6998","DOI":"10.1074\/jbc.M008591200","volume":"276","author":"SS Hegde","year":"2001","unstructured":"Hegde, S. S. & Shrader, T. E. FemABX family members are novel nonribosomal peptidyltransferases and important pathogen-specific drug targets. Journal of Biological Chemistry 276, 6998\u20137003 (2001).","journal-title":"Journal of Biological Chemistry"},{"key":"BFsrep35442_CR42","doi-asserted-by":"publisher","first-page":"1445","DOI":"10.1111\/j.1365-2958.2009.06942.x","volume":"74","author":"DF Fujimoto","year":"2009","unstructured":"Fujimoto, D. F. et al. Staphylococcus aureus SarA is a regulatory protein responsive to redox and pH that can support bacteriophage lambda integrase\u2010mediated excision\/recombination. Molecular microbiology 74, 1445\u20131458 (2009).","journal-title":"Molecular microbiology"},{"key":"BFsrep35442_CR43","doi-asserted-by":"publisher","first-page":"3301","DOI":"10.1128\/JB.01496-08","volume":"191","author":"A Ballal","year":"2009","unstructured":"Ballal, A. & Manna, A. C. Regulation of superoxide dismutase (sod) genes by SarA in Staphylococcus aureus. Journal of bacteriology 191, 3301\u20133310 (2009).","journal-title":"Journal of bacteriology"},{"key":"BFsrep35442_CR44","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1111\/j.1365-2958.2005.04700.x","volume":"57","author":"G Kovacikova","year":"2005","unstructured":"Kovacikova, G., Lin, W. & Skorupski, K. Dual regulation of genes involved in acetoin biosynthesis and motility\/biofilm formation by the virulence activator AphA and the acetate\u2010responsive LysR\u2010type regulator AlsR in Vibrio cholerae. Molecular microbiology 57, 420\u2013433 (2005).","journal-title":"Molecular microbiology"},{"key":"BFsrep35442_CR45","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1089\/ars.2006.8.753","volume":"8","author":"L Masip","year":"2006","unstructured":"Masip, L., Veeravalli, K. & Georgiou, G. The many faces of glutathione in bacteria. Antioxidants & redox signaling 8, 753\u2013762 (2006).","journal-title":"Antioxidants & redox signaling"},{"key":"BFsrep35442_CR46","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1111\/j.1574-695X.2011.00781.x","volume":"61","author":"KJ Wetzel","year":"2011","unstructured":"Wetzel, K. J., Bjorge, D. & Schwan, W. R. Mutational and transcriptional analyses of the Staphylococcus aureus low-affinity proline transporter OpuD during in vitro growth and infection of murine tissues. FEMS Immunology & Medical Microbiology 61, 346\u2013355 (2011).","journal-title":"FEMS Immunology & Medical Microbiology"},{"key":"BFsrep35442_CR47","doi-asserted-by":"publisher","first-page":"27689","DOI":"10.1074\/jbc.M202094200","volume":"277","author":"G Zhao","year":"2002","unstructured":"Zhao, G. et al. Iron and hydrogen peroxide detoxification properties of DNA-binding protein from starved cells A ferritin-like DNA-binding protein of Escherichia coli. Journal of Biological Chemistry 277, 27689\u201327696 (2002).","journal-title":"Journal of Biological Chemistry"},{"key":"BFsrep35442_CR48","doi-asserted-by":"publisher","first-page":"21943","DOI":"10.1074\/jbc.M110.117283","volume":"285","author":"JR Cussiol","year":"2010","unstructured":"Cussiol, J. R., Alegria, T. G., Szweda, L. I. & Netto, L. E. Ohr (organic hydroperoxide resistance protein) possesses a previously undescribed activity, lipoyl-dependent peroxidase. Journal of Biological Chemistry 285, 21943\u201321950 (2010).","journal-title":"Journal of Biological Chemistry"},{"key":"BFsrep35442_CR49","doi-asserted-by":"publisher","first-page":"2289","DOI":"10.1099\/mic.0.2007\/005942-0","volume":"153","author":"E Bore","year":"2007","unstructured":"Bore, E., Langsrud, S., Langsrud, \u00d8., Rode, T. M. & Holck, A. Acid-shock responses in Staphylococcus aureus investigated by global gene expression analysis. Microbiology 153, 2289\u20132303 (2007).","journal-title":"Microbiology"},{"key":"BFsrep35442_CR50","doi-asserted-by":"publisher","first-page":"2894","DOI":"10.1128\/JCM.41.7.2894-2899.2003","volume":"41","author":"H Fang","year":"2003","unstructured":"Fang, H. & Hedin, G. Rapid screening and identification of methicillin-resistant Staphylococcus aureus from clinical samples by selective-broth and real-time PCR assay. Journal of Clinical Microbiology 41, 2894\u20132899 (2003).","journal-title":"Journal of Clinical Microbiology"},{"key":"BFsrep35442_CR51","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1016\/j.ijfoodmicro.2010.07.037","volume":"143","author":"KH Teh","year":"2010","unstructured":"Teh, K. H., Flint, S. & French, N. Biofilm formation by Campylobacter jejuni in controlled mixed-microbial populations. International journal of food microbiology 143, 118\u2013124 (2010).","journal-title":"International journal of food microbiology"},{"key":"BFsrep35442_CR52","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1016\/j.micpath.2011.02.009","volume":"50","author":"YA Almofti","year":"2011","unstructured":"Almofti, Y. A., Dai, M., Sun, Y., Haihong, H. & Yuan, Z. Impact of erythromycin resistance on the virulence properties and fitness of Campylobacter jejuni. Microbial pathogenesis 50, 336\u2013342, 10.1016\/j.micpath.2011.02.009 (2011).","journal-title":"Microbial pathogenesis"},{"key":"BFsrep35442_CR53","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1093\/jac\/dkh078","volume":"53","author":"WJ Weiss","year":"2004","unstructured":"Weiss, W. J. et al. Effect of srtA and srtB gene expression on the virulence of Staphylococcus aureus in animal models of infection. Journal of Antimicrobial Chemotherapy 53, 480\u2013486 (2004).","journal-title":"Journal of Antimicrobial Chemotherapy"},{"key":"BFsrep35442_CR54","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/gb-2010-11-10-r106","volume":"11","author":"S Anders","year":"2010","unstructured":"Anders, S. & Huber, W. Differential expression analysis for sequence count data. Genome biology 11, 1 (2010).","journal-title":"Genome biology"},{"key":"BFsrep35442_CR55","doi-asserted-by":"publisher","first-page":"D258","DOI":"10.1093\/nar\/gkh036","volume":"32","author":"GO Consortium","year":"2004","unstructured":"Consortium, G. O. The Gene Ontology (GO) database and informatics resource. Nucleic acids research 32, D258\u2013D261 (2004).","journal-title":"Nucleic acids research"},{"key":"BFsrep35442_CR56","doi-asserted-by":"crossref","unstructured":"Aoki-Kinoshita, K. F. & Kanehisa, M. Gene annotation and pathway mapping in KEGG. Comparative Genomics, 71\u201391 (2007).","DOI":"10.1007\/978-1-59745-515-2_6"},{"key":"BFsrep35442_CR57","doi-asserted-by":"publisher","first-page":"3020","DOI":"10.1128\/JB.00017-11","volume":"193","author":"Y Lu","year":"2011","unstructured":"Lu, Y. et al. An orphan histidine kinase, OhkA, regulates both secondary metabolism and morphological differentiation in Streptomyces coelicolor. Journal of bacteriology 193, 3020\u20133032 (2011).","journal-title":"Journal of bacteriology"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/srep35442.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/srep35442","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/srep35442.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,5]],"date-time":"2023-01-05T00:14:31Z","timestamp":1672877671000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/srep35442"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10,14]]},"references-count":57,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2016,12,16]]}},"alternative-id":["BFsrep35442"],"URL":"https:\/\/doi.org\/10.1038\/srep35442","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,10,14]]},"assertion":[{"value":"17 August 2016","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 September 2016","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 October 2016","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing financial interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"35442"}}