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Disinhibited behaviour, a risk factor for overconsumption, is characterized by reduced prefrontal cortex activity, which in turn modulates vagal tone; a phenomenon associated with glucoregulation. This double blind randomised controlled trial explored for the first time the influence of disinhibited eating and vagal tone (heart rate variability (HRV)) on hunger and the postprandial response to GL. Blood glucose (BG) and hunger were measured 30 and 150\u2009min after consumption of water, glucose or isomaltulose (low glycemic sugar). After consuming glucose, independently of BMI or habitual diet, those with the highest levels of disinhibition had higher BG levels after thirty minutes (B\u2009=\u20090.192, 95% CI LL. 086, UL 0.297), and lower BG after one hundred and fifty minutes (B\u2009=\u2009\u22120.240, 95% CI LL \u22120.348, UL \u22120.131). BG was related to hunger but only in low disinhibited eaters. Disinhibited eaters were characterised by a reduced HRV which was related to greater BG excursions (B\u2009=\u20090.407, 95% CI LL 0.044, UL 1.134). These findings highlight novel mechanisms by which disinhibited eating leads to obesity and insulin resistance. This trial was registered at clinicaltrials.gov NCT02827318.<\/jats:p>","DOI":"10.1038\/srep35740","type":"journal-article","created":{"date-parts":[[2016,10,20]],"date-time":"2016-10-20T08:59:26Z","timestamp":1476953966000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Eating disinhibition and vagal tone moderate the postprandial response to glycemic load: a randomised controlled trial"],"prefix":"10.1038","volume":"6","author":[{"given":"Hayley A.","family":"Young","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heather","family":"Watkins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2016,10,20]]},"reference":[{"key":"BFsrep35740_CR1","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1093\/ajcn\/34.3.362","volume":"34","author":"D Jenkins","year":"1981","unstructured":"Jenkins, D. et al. 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