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Pro-resolution mediators, such as lipoxin A<jats:sub>4<\/jats:sub> (LXA<jats:sub>4<\/jats:sub>), are produced during inflammation returning the tissue to homeostasis and are also produced in non-inflamed tissues. The purpose of this study was to determine the actions of LXA<jats:sub>4<\/jats:sub> on cultured human conjunctival goblet cell mucin secretion and increase in intracellular [Ca<jats:sup>2+<\/jats:sup>] ([Ca<jats:sup>2+<\/jats:sup>]<jats:sub>i<\/jats:sub>) and on histamine-stimulated responses. LXA<jats:sub>4<\/jats:sub> increased mucin secretion and [Ca<jats:sup>2+<\/jats:sup>]<jats:sub>i<\/jats:sub>, and activated ERK1\/2 in human goblet cells. Addition of LXA<jats:sub>4<\/jats:sub> before resolvin D1 (RvD1) decreased RvD1 responses though RvD1 did not block LXA<jats:sub>4<\/jats:sub> responses. LXA<jats:sub>4<\/jats:sub> inhibited histamine-stimulated increases in mucin secretion, [Ca<jats:sup>2+<\/jats:sup>]<jats:sub>i<\/jats:sub>, and ERK1\/2 activation through activation of \u03b2-adrenergic receptor kinase 1. We conclude that conjunctival goblet cells respond to LXA<jats:sub>4<\/jats:sub> through the ALX\/FPR2 receptor to maintain homeostasis of the ocular surface and regulate histamine responses and could provide a new therapeutic approach for allergic conjunctivitis and dry eye diseases.<\/jats:p>","DOI":"10.1038\/srep36124","type":"journal-article","created":{"date-parts":[[2016,11,8]],"date-time":"2016-11-08T10:05:47Z","timestamp":1478599547000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Lipoxin A4 Counter-regulates Histamine-stimulated Glycoconjugate Secretion in Conjunctival Goblet Cells"],"prefix":"10.1038","volume":"6","author":[{"given":"Robin R.","family":"Hodges","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dayu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie A.","family":"Shatos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles N.","family":"Serhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darlene A.","family":"Dartt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,11,8]]},"reference":[{"key":"BFsrep36124_CR1","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1006\/bbrc.1997.7051","volume":"236","author":"T Inatomi","year":"1997","unstructured":"Inatomi, T., Tisdale, A. 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