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This case-control study recruited 713 late-onset Alzheimer\u2019s disease (LOAD) cases and controls aged \u226565 from three teaching hospitals in northern Taiwan from 2007 to 2010. Performance metrics were used to select SNPs in stage 1, which were then genotyped to another dataset (stage 2). Four SNPs (<jats:italic>CPXM2<\/jats:italic> rs2362967, <jats:italic>APOC1<\/jats:italic> rs4420638, <jats:italic>ZNF521<\/jats:italic> rs7230380, and rs12965520) were identified for LOAD by both traditional <jats:italic>P<\/jats:italic>-values (without correcting for multiple tests) and performance metrics. After correction for multiple tests, no SNPs were identified by traditional <jats:italic>P<\/jats:italic>-values. Simultaneous testing of <jats:italic>APOE<\/jats:italic> e4 and <jats:italic>APOC1<\/jats:italic> rs4420638 (the SNP with the best performance in the performance metrics) significantly improved the low sensitivity of <jats:italic>APOE<\/jats:italic> e4 from 0.50 to 0.78. A point-based genetic model including these 2 SNPs and important covariates was constructed. Compared with elders with low-risks score (0\u20136), elders belonging to moderate-risk (score\u2009=\u20097\u201311) and high-risk (score\u2009=\u200912\u201318) groups showed a significantly increased risk of LOAD (adjusted odds ratio\u2009=\u20097.80 and 46.93, respectively; <jats:italic>P<\/jats:italic><jats:sub>trend<\/jats:sub>\u2009&lt;\u20090.0001). Performance metrics allow for identification of markers with moderate effect and are useful for creating genetic tests with clinical and public health implications.<\/jats:p>","DOI":"10.1038\/srep36155","type":"journal-article","created":{"date-parts":[[2016,11,2]],"date-time":"2016-11-02T10:46:35Z","timestamp":1478083595000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Performance Metrics for Selecting Single Nucleotide Polymorphisms in Late-onset Alzheimer\u2019s Disease"],"prefix":"10.1038","volume":"6","author":[{"given":"Yen-Ching","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chi-Jung","family":"Hsiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chien-Cheng","family":"Jung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui-Han","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jen-Hau","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen-Chung","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeng-Min","family":"Chiou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ta-Fu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li-Li","family":"Wen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping-Keung","family":"Yip","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi-Min","family":"Chu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chien-Jen","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hwai-I","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2016,11,2]]},"reference":[{"key":"BFsrep36155_CR1","unstructured":"Alzheimer\u2019s Association. 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