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An investigation was conducted on the potential predictors of fasting insulin and insulin resistance among overweight\/obese adolescents in a developing Asian country. A total of 173 overweight\/obese (BMI\u2009&gt;\u200985\n                    <jats:sup>th<\/jats:sup>\n                    percentile) multi-ethnic Malaysian adolescents aged 13 were recruited from 23 randomly selected schools in this cross-sectional study. Waist circumference (WC), body fat percentage (BF%), physical fitness score (PFS), fasting glucose and fasting insulin were measured. Insulin resistance was calculated using homeostasis model assessment of insulin resistance (HOMA-IR). Adjusted stepwise multiple regression analysis was performed to predict fasting insulin and HOMA-IR. Covariates included pubertal stage, socioeconomic status, nutritional and physical activity scores. One-third of our adolescents were insulin resistant, with girls having significantly higher fasting insulin and HOMA-IR than boys. Gender, pubertal stage, BMI, WC and BF% had significant, positive moderate correlations with fasting insulin and HOMA-IR while PFS was inversely correlated (\n                    <jats:italic>p\u2009<\/jats:italic>\n                    &lt;\u20090.05). Fasting insulin was primarily predicted by gender-girls (Beta\u2009=\u20090.305,\n                    <jats:italic>p\u2009<\/jats:italic>\n                    &lt;\u20090.0001), higher BMI (Beta\u2009=\u2009\u22120.254,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.02) and greater WC (Beta\u2009=\u20090.242,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.03). This study demonstrated that gender, BMI and WC are simple predictors of fasting insulin and insulin resistance in overweight\/obese adolescents.\n                  <\/jats:p>","DOI":"10.1038\/srep36270","type":"journal-article","created":{"date-parts":[[2016,11,8]],"date-time":"2016-11-08T05:38:59Z","timestamp":1478583539000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Determinants of High Fasting Insulin and Insulin Resistance Among Overweight\/Obese Adolescents"],"prefix":"10.1038","volume":"6","author":[{"given":"Jerri Chiu Yun","family":"Ling","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohd Nahar Azmi","family":"Mohamed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Yazid","family":"Jalaludin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjay","family":"Rampal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nur Lisa","family":"Zaharan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahurin","family":"Mohamed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,11,8]]},"reference":[{"key":"BFsrep36270_CR1","doi-asserted-by":"publisher","first-page":"2674","DOI":"10.2337\/dc10-0085","volume":"33","author":"IM Libman","year":"2010","unstructured":"Libman, I. 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