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Elimination models used to predict programmatic endpoints include parameters for vector-specific transmission dynamics, despite the fact that our knowledge of the host-seeking behaviour of filariasis infected mosquitoes is lacking. We observed a dynamic, stage-specific and density dependent change in <jats:italic>Aedes aegypti<\/jats:italic> behaviour towards host cues when exposed to <jats:italic>Brugia malayi<\/jats:italic> filarial parasites. Infected mosquitoes exhibited reduced activation and flight towards a host during the period of larval development (L1\/L2), transitioning to a 5 fold increase in activation and flight towards a host when infective stage larvae (L3) were present (p\u2009&lt;\u20090.001). In uninfected control mosquitoes, we observed a reduction in convergence towards a host during the same period. Furthermore, this behaviour was density dependent with non-activated mosquitoes harbouring a greater burden of L1 and L2 larvae while activated mosquitoes harboured a greater number of L3 (p\u2009&lt;\u20090.001). Reductions in fecundity were also density-dependent, and extended to mosquitoes that were exposed to microfilariae but did not support larval development.<\/jats:p>","DOI":"10.1038\/srep36319","type":"journal-article","created":{"date-parts":[[2016,10,31]],"date-time":"2016-10-31T11:21:40Z","timestamp":1477912900000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Filarial infection influences mosquito behaviour and fecundity"],"prefix":"10.1038","volume":"6","author":[{"given":"Katherine","family":"Gleave","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darren","family":"Cook","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark J.","family":"Taylor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa J.","family":"Reimer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,10,31]]},"reference":[{"key":"BFsrep36319_CR1","unstructured":"World Health Organization. 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