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However, it is not clear how tomato plants physiologically respond to <jats:italic>V. dahliae<\/jats:italic> infection and what roles sulfur plays in the disease-resistance. Pot experiments were performed to examine changes in the physiology and sulfur metabolism of tomato roots infected by <jats:italic>V. dahliae<\/jats:italic> under the companion cropping (tomato\/potato onion). The results showed that the companion cropping increased the content of total phenol, lignin and glutathione and increased the activities of peroxidase, polyphenol oxidase and phenylalanine ammonia lyase in the roots of tomato plants. RNA-seq analysis showed that the expressions of genes involved in sulfur uptake and assimilation, and the formation of sulfur-containing defense compounds (SDCs) were up-regulated in the <jats:italic>V. dahlia-<\/jats:italic>infected tomatoes in the companion cropping. In addition, the interactions among tomato, potato onion and <jats:italic>V. dahliae<\/jats:italic> induced the expression of the high- affinity sulfate transporter gene in the tomato roots. These results suggest that sulfur may play important roles in tomato disease resistance against <jats:italic>V. dahliae.<\/jats:italic><\/jats:p>","DOI":"10.1038\/srep36445","type":"journal-article","created":{"date-parts":[[2016,11,3]],"date-time":"2016-11-03T10:10:08Z","timestamp":1478167808000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Physiological response and sulfur metabolism of the V. dahliae-infected tomato plants in tomato\/potato onion companion cropping"],"prefix":"10.1038","volume":"6","author":[{"given":"Xuepeng","family":"Fu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunxia","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xingang","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shouwei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fengzhi","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2016,11,3]]},"reference":[{"key":"BFsrep36445_CR1","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1186\/1471-2229-10-232","volume":"10","author":"C Gayoso","year":"2010","unstructured":"Gayoso, C., Pomar, F., Novo-Uzal, E., Merino, F. & de Ilarduya, O. 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