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FUZZY ONIONS (FZO) proteins in yeast, flies, and mammals are known to affect mitochondrial fusion and function. Arabidopsis FZO-LIKE (FZL) was shown as a chloroplast protein that regulates chloroplast morphology and cell death. We cloned the <jats:italic>FZL<\/jats:italic> gene based on the lesion mimic phenotype conferred by an <jats:italic>fzl<\/jats:italic> mutation. Here we provide evidence to support that <jats:italic>FZL<\/jats:italic> has evolved new function different from its homologs from other organisms. We found that <jats:italic>fzl<\/jats:italic> mutants showed enhanced disease resistance to the bacterial pathogen <jats:italic>Pseudomonas syringae<\/jats:italic> and the oomycete pathogen <jats:italic>Hyaloperonospora arabidopsidis<\/jats:italic>. Besides altered chloroplast morphology and cell death, <jats:italic>fzl<\/jats:italic> showed the activation of reactive oxygen species (ROS) and autophagy pathways. <jats:italic>FZL<\/jats:italic> and the defense signaling molecule salicylic acid form a negative feedback loop in defense and cell death control. <jats:italic>FZL<\/jats:italic> did not complement the yeast strain lacking the <jats:italic>FZO1<\/jats:italic> gene. Together these data suggest that the Arabidopsis <jats:italic>FZL<\/jats:italic> gene is a negative regulator of cell death and disease resistance, possibly through regulating ROS and autophagy pathways in the chloroplast.<\/jats:p>","DOI":"10.1038\/srep37797","type":"journal-article","created":{"date-parts":[[2016,11,29]],"date-time":"2016-11-29T14:08:52Z","timestamp":1480428532000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["A Role of the FUZZY ONIONS LIKE Gene in Regulating Cell Death and Defense in Arabidopsis"],"prefix":"10.1038","volume":"6","author":[{"given":"Arianne","family":"Tremblay","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Savanna","family":"Seabolt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongyun","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"B\u00f6ckler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominique N.","family":"Tate","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vy Thuy","family":"Duong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nan","family":"Yao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hua","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2016,11,29]]},"reference":[{"key":"BFsrep37797_CR1","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/j.tplants.2005.01.006","volume":"10","author":"WG van Doorn","year":"2005","unstructured":"van Doorn, W. 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