{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T00:31:57Z","timestamp":1789432317702,"version":"build-2803163510"},"reference-count":63,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2016,11,29]],"date-time":"2016-11-29T00:00:00Z","timestamp":1480377600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2016,11,29]],"date-time":"2016-11-29T00:00:00Z","timestamp":1480377600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The present study was designed to investigate the potency of hydroxychavicol on selected cutaneous human pathogenic fungi by the use of\n                    <jats:italic>in vitro<\/jats:italic>\n                    and\n                    <jats:italic>in vivo<\/jats:italic>\n                    assays and mechanistic characterization along with toxicological effects. Hydroxychavicol consistently displayed a fungicidal effect against all fungal species tested. Inoculum concentrations over the range of 10\n                    <jats:sup>4<\/jats:sup>\n                    to 10\n                    <jats:sup>7<\/jats:sup>\n                    \u2009CFU\/ml did not significantly alter its antifungal potential and time\u2013kill curve results revealed concentration\u2013dependent killing. It also inhibited the growth of biofilm generated by\n                    <jats:italic>Trichophyton mentagrophytes<\/jats:italic>\n                    and\n                    <jats:italic>Candida parapsilosis<\/jats:italic>\n                    and reduced the preformed biofilms. Hydroxychavicol was highly effective in the treatment, and mycological eradication of an experimentally induced topical infection model of dermatophytosis (tinea corporis) and cutaneous candidiasis in guinea pigs, respectively. The mode of action of hydroxychavicol appears to originate from the disruption of cell membrane integrity. Administration of hydroxychavicol in mice at 500\u2009mg per kg of body weight by orally produced no overt toxicity. The retention capacity of hydroxychavicol\n                    <jats:italic>in vitro<\/jats:italic>\n                    , in the presence of keratin has attributed to its\n                    <jats:italic>in vivo<\/jats:italic>\n                    effectiveness in the guinea pig model of topical infections. Furthermore, it is suggestive of its potential use as phytochemical for topical use in cutaneous fungal infections.\n                  <\/jats:p>","DOI":"10.1038\/srep37867","type":"journal-article","created":{"date-parts":[[2016,11,29]],"date-time":"2016-11-29T05:57:53Z","timestamp":1480399073000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Hydroxychavicol: A phytochemical targeting cutaneous fungal infections"],"prefix":"10.1038","volume":"6","author":[{"given":"Intzar","family":"Ali","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naresh Kumar","family":"Satti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prabhu","family":"Dutt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajendra","family":"Prasad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inshad Ali","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,11,29]]},"reference":[{"key":"BFsrep37867_CR1","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1111\/j.1439-0507.2008.01606.x","volume":"51","author":"B Havlickova","year":"2008","unstructured":"Havlickova, B., Czaika, V. 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