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Seasonal epidemics of cholera reportedly collapse due to predation of the pathogen by phages. However, it is not clear how sufficient number of the bacteria survive to seed the environment in the subsequent epidemic season. We found that bacterial cell density-dependent gene expression termed \u201cquorum sensing\u201d which is regulated by signal molecules called autoinducers (AIs) can protect <jats:italic>V. cholerae<\/jats:italic> against predatory phages. <jats:italic>V. cholerae<\/jats:italic> mutant strains carrying inactivated AI synthase genes were significantly more susceptible to multiple phages compared to the parent bacteria. Likewise when mixed cultures of phage and bacteria were supplemented with exogenous autoinducers CAI-1 or AI-2 produced by recombinant strains carrying cloned AI synthase genes, increased survival of <jats:italic>V. cholerae<\/jats:italic> and a decrease in phage titer was observed. Mutational analyses suggested that the observed effects of autoinducers are mediated in part through the quorum sensing-dependent production of haemaglutinin protease, and partly through downregulation of phage receptors. These results have implication in developing strategies for phage mediated control of cholera.<\/jats:p>","DOI":"10.1038\/srep37956","type":"journal-article","created":{"date-parts":[[2016,11,28]],"date-time":"2016-11-28T11:23:51Z","timestamp":1480332231000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":100,"title":["Quorum Regulated Resistance of Vibrio cholerae against Environmental Bacteriophages"],"prefix":"10.1038","volume":"6","author":[{"given":"M. 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