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We have demonstrated that the metabolic phenotype of single or combined SST\/CORT KO-models is not drastically altered under normal conditions. However, the biological actions of SST\/CORT are conditioned by the metabolic-status (e.g. obesity). Therefore, we used male\/female SST- and CORT-KO mice fed low-fat (LF) or high-fat (HF) diet to explore the interplay between SST\/CORT and obesity in the control of relevant pituitary-axes and whole-body metabolism. Our results showed that the SST\/CORT role in the control of GH\/prolactin secretions is maintained under LF- and HF-diet conditions as SST-KOs presented higher GH\/prolactin-levels, while CORT-KOs displayed higher GH- and lower prolactin-levels than controls under both diets. Moreover, the impact of lack of SST\/CORT on the metabolic-function was gender- and diet-dependent. Particularly, SST-KOs were more sensitive to HF-diet, exhibiting altered growth and body-composition (fat\/lean percentage) and impaired glucose\/insulin-metabolism, especially in males. Conversely, only males CORT-KO under LF-diet conditions exhibited significant alterations, displaying higher glucose-levels and insulin-resistance. Altogether, these data demonstrate a tight interplay between SST\/CORT-axis and the metabolic status in the control of endocrine\/metabolic functions and unveil a clear dissociation of SST\/CORT roles.<\/jats:p>","DOI":"10.1038\/srep37992","type":"journal-article","created":{"date-parts":[[2016,11,30]],"date-time":"2016-11-30T10:22:36Z","timestamp":1480501356000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Obesity- and gender-dependent role of endogenous somatostatin and cortistatin in the regulation of endocrine and metabolic homeostasis in mice"],"prefix":"10.1038","volume":"6","author":[{"given":"Ra\u00fal M.","family":"Luque","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9","family":"Cordoba-Chacon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana I.","family":"Pozo-Salas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bego\u00f1a","family":"Porteiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"de Lecea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rub\u00e9n","family":"Nogueiras","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel D.","family":"Gahete","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justo P.","family":"Casta\u00f1o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,11,30]]},"reference":[{"key":"BFsrep37992_CR1","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1111\/j.1749-6632.2010.05511.x","volume":"1200","author":"MD Gahete","year":"2010","unstructured":"Gahete, M. 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