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Mutations in <jats:italic>DNM2<\/jats:italic> are common in early T-cell precursor acute lymphoblastic leukemia. However, <jats:italic>DNM2<\/jats:italic> expression in other types of ALL are not reported. We studied <jats:italic>DNM2<\/jats:italic> mRNA level in adults with B- and T-cell ALL. We found <jats:italic>DNM2<\/jats:italic> is more highly expressed compared with normals in both forms of ALL. High <jats:italic>DNM2<\/jats:italic> expression is associated with some clinical and laboratory features, inferior outcomes and with leukaemia cell proliferation. We also found Ikaros directly binds the <jats:italic>DNM2<\/jats:italic> promoter and suppresses <jats:italic>DNM2<\/jats:italic> expression. Consequently <jats:italic>IKZF1<\/jats:italic> deletion is associated with high <jats:italic>DNM2<\/jats:italic> expression. Conversely, casein kinase-2 (CK2)-inhibitor increases Ikaros function thereby inhibiting <jats:italic>DNM2<\/jats:italic> expression. Inhibiting <jats:italic>DNM2<\/jats:italic> suppresses proliferation of leukemia cells and synergizes with CK2 inhibition. Our data indicate high <jats:italic>DNM2<\/jats:italic> expression is associated with Ikaros dysregulation and may be important in the development of B-ALL.<\/jats:p>","DOI":"10.1038\/srep38004","type":"journal-article","created":{"date-parts":[[2016,11,25]],"date-time":"2016-11-25T10:06:50Z","timestamp":1480068410000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Targeting High Dynamin-2 (DNM2) Expression by Restoring Ikaros Function in Acute Lymphoblastic Leukemia"],"prefix":"10.1038","volume":"6","author":[{"given":"Zheng","family":"Ge","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianyong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baoan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianyu","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sinisa","family":"Dovat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert Peter","family":"Gale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunhua","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,11,25]]},"reference":[{"key":"BFsrep38004_CR1","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1038\/onc.2011.329","volume":"31","author":"RD Eppinga","year":"2012","unstructured":"Eppinga, R. 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