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The depletion of chromosome scaffold proteins does not prevent chromosome condensation despite structural defects. This suggests that other factors contribute to condensation. Here we investigated the contribution of divalent cations, particularly Ca\n                    <jats:sup>2+<\/jats:sup>\n                    , to chromosome condensation\n                    <jats:italic>in vitro<\/jats:italic>\n                    and\n                    <jats:italic>in vivo<\/jats:italic>\n                    . Ca\n                    <jats:sup>2+<\/jats:sup>\n                    depletion caused defects in proper mitotic progression, particularly in chromosome condensation after the breakdown of the nuclear envelope. Fluorescence lifetime imaging microscopy-F\u00f6rster resonance energy transfer and electron microscopy demonstrated that chromosome condensation is influenced by Ca\n                    <jats:sup>2+<\/jats:sup>\n                    . Chromosomes had compact globular structures when exposed to Ca\n                    <jats:sup>2+<\/jats:sup>\n                    and expanded fibrous structures without Ca\n                    <jats:sup>2+<\/jats:sup>\n                    . Therefore, we have clearly demonstrated a role for Ca\n                    <jats:sup>2+<\/jats:sup>\n                    in the compaction of chromatin fibres.\n                  <\/jats:p>","DOI":"10.1038\/srep38281","type":"journal-article","created":{"date-parts":[[2016,12,2]],"date-time":"2016-12-02T05:48:05Z","timestamp":1480657685000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":57,"title":["Calcium ions function as a booster of chromosome condensation"],"prefix":"10.1038","volume":"6","author":[{"given":"Rinyaporn","family":"Phengchat","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideaki","family":"Takata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenichi","family":"Morii","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriko","family":"Inada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideji","family":"Murakoshi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susumu","family":"Uchiyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiichi","family":"Fukui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,12,2]]},"reference":[{"key":"BFsrep38281_CR1","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/S0092-8674(00)81958-3","volume":"98","author":"RD Kornberg","year":"1999","unstructured":"Kornberg, R. 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