{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T07:21:01Z","timestamp":1775892061396,"version":"3.50.1"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2016,12,5]],"date-time":"2016-12-05T00:00:00Z","timestamp":1480896000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2016,12,5]],"date-time":"2016-12-05T00:00:00Z","timestamp":1480896000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A recent study showed that posterior circulation plaques have a greater capacity for positive remodeling in a non-Asian population. We aimed to investigate if the features of plaques in the middle cerebral artery (MCA) were different from those in the basilar artery (BA) in a northern Chinese population. We retrospectively analysed the records of 71 consecutive patients with acute ischemic stroke. All patients had at least one MCA or BA plaque with early or mild (&lt;50% stenosis) atherosclerosis identified using vessel wall magnetic resonance imaging. The remodeling ratio, eccentricity index, and plaque range were compared between MCA and BA plaques using multilevel analysis. A total of 101 plaques were included. There were 70 plaques located in the MCA and 31 plaques located in the BA. The features of non-advanced atherosclerotic plaques did not differ between the MCA and BA when accounting for the degree of stenosis or plaque burden in a northern Chinese population. Symptomatic plaques were associated with a higher eccentricity index and smaller plaque range than asymptomatic plaques under the same plaque burden. Further studies are warranted to investigate the progression of atherosclerosis in different intracranial arteries.<\/jats:p>","DOI":"10.1038\/srep38534","type":"journal-article","created":{"date-parts":[[2016,12,5]],"date-time":"2016-12-05T10:13:46Z","timestamp":1480932826000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Vessel wall differences between middle cerebral artery and basilar artery plaques on magnetic resonance imaging"],"prefix":"10.1038","volume":"6","author":[{"given":"Peng-Peng","family":"Niu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yao","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong-Wei","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhen-Ni","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hang","family":"Jin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2016,12,5]]},"reference":[{"key":"BFsrep38534_CR1","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1111\/j.1747-4949.2006.00045.x","volume":"1","author":"LK Wong","year":"2006","unstructured":"Wong, L. K. Global burden of intracranial atherosclerosis. Int J Stroke 1, 158\u2013159 (2006).","journal-title":"Int J Stroke"},{"key":"BFsrep38534_CR2","doi-asserted-by":"publisher","first-page":"1106","DOI":"10.1016\/S1474-4422(13)70195-9","volume":"12","author":"CA Holmstedt","year":"2013","unstructured":"Holmstedt, C. A., Turan, T. N. & Chimowitz, M. I. Atherosclerotic intracranial arterial stenosis: risk factors, diagnosis, and treatment. Lancet Neurol 12, 1106\u20131114 (2013).","journal-title":"Lancet Neurol"},{"key":"BFsrep38534_CR3","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1161\/STROKEAHA.112.664680","volume":"44","author":"JD Bodle","year":"2013","unstructured":"Bodle, J. D. et al. High-resolution magnetic resonance imaging: an emerging tool for evaluating intracranial arterial disease. Stroke 44, 287\u2013292 (2013).","journal-title":"Stroke"},{"key":"BFsrep38534_CR4","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1016\/j.atherosclerosis.2014.10.007","volume":"237","author":"TN Turan","year":"2014","unstructured":"Turan, T. N. et al. Intracranial atherosclerosis: correlation between in-vivo 3T high resolution MRI and pathology. Atherosclerosis 237, 460\u2013463 (2014).","journal-title":"Atherosclerosis"},{"key":"BFsrep38534_CR5","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1161\/STROKEAHA.115.011086","volume":"47","author":"WJ Yang","year":"2016","unstructured":"Yang, W. J. et al. In Vitro Assessment of Histology Verified Intracranial Atherosclerotic Disease by 1.5T Magnetic Resonance Imaging: Concentric or Eccentric? Stroke 47, 527\u2013530 (2016).","journal-title":"Stroke"},{"key":"BFsrep38534_CR6","doi-asserted-by":"publisher","first-page":"E19","DOI":"10.1111\/ijs.12277","volume":"9","author":"XY Chen","year":"2014","unstructured":"Chen, X. Y., Wong, K. S., Lam, W. W. & Ng, H. K. High signal on T1 sequence of magnetic resonance imaging confirmed to be intraplaque haemorrhage by histology in middle cerebral artery. Int J Stroke 9, E19 (2014).","journal-title":"Int J Stroke"},{"key":"BFsrep38534_CR7","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1136\/jnnp-2015-312020","volume":"87","author":"MD Alexander","year":"2016","unstructured":"Alexander, M. D. et al. High-resolution intracranial vessel wall imaging: imaging beyond the lumen. J Neurol Neurosurg Psychiatry 87, 589\u2013597 (2016).","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"BFsrep38534_CR8","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.atherosclerosis.2016.03.033","volume":"249","author":"Y Jiang","year":"2016","unstructured":"Jiang, Y. et al. Ex-vivo imaging and plaque type classification of intracranial atherosclerotic plaque using high resolution MRI. Atherosclerosis 249, 10\u201316 (2016).","journal-title":"Atherosclerosis"},{"key":"BFsrep38534_CR9","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1093\/eurheartj\/ehr332","volume":"33","author":"N Bianda","year":"2012","unstructured":"Bianda, N. et al. Progression of human carotid and femoral atherosclerosis: a prospective follow-up study by magnetic resonance vessel wall imaging. Eur Heart J 33, 230\u2013237 (2012).","journal-title":"Eur Heart J"},{"key":"BFsrep38534_CR10","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1161\/STROKEAHA.115.009955","volume":"47","author":"Y Qiao","year":"2016","unstructured":"Qiao, Y. et al. Patterns and Implications of Intracranial Arterial Remodeling in Stroke Patients. Stroke 47, 434\u2013440 (2016).","journal-title":"Stroke"},{"key":"BFsrep38534_CR11","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1177\/0013164405278558","volume":"65","author":"JL Peugh","year":"2005","unstructured":"Peugh, J. L. & Enders, C. K. Using the SPSS mixed procedure to fit cross-sectional and longitudinal multilevel models. Educational and Psychological Measurement 65, 811\u2013835 (2005).","journal-title":"Educational and Psychological Measurement"},{"key":"BFsrep38534_CR12","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1186\/s12913-015-1157-9","volume":"15","author":"K Nilsson","year":"2015","unstructured":"Nilsson, K. et al. Associations between workplace affiliation and phlebotomy practices regarding patient identification and test request handling practices in primary healthcare centres: a multilevel model approach. BMC Health Serv Res 15, 503 (2015).","journal-title":"BMC Health Serv Res"},{"key":"BFsrep38534_CR13","first-page":"e86","volume":"47","author":"J Gutierrez","year":"2016","unstructured":"Gutierrez, J. & Elkind, M. S. Letter by Gutierrez and Elkind Regarding Article, \u201cPatterns and Implications of Intracranial Arterial Remodeling in Patients With Stroke\u201d. Stroke 47, e86 (2016).","journal-title":"Stroke"},{"key":"BFsrep38534_CR14","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1016\/j.atherosclerosis.2010.06.035","volume":"212","author":"WH Xu","year":"2010","unstructured":"Xu, W. H. et al. In vivo high-resolution MR imaging of symptomatic and asymptomatic middle cerebral artery atherosclerotic stenosis. Atherosclerosis 212, 507\u2013511 (2010).","journal-title":"Atherosclerosis"},{"key":"BFsrep38534_CR15","doi-asserted-by":"publisher","first-page":"700","DOI":"10.1016\/j.jocn.2014.10.018","volume":"22","author":"DL Zhao","year":"2015","unstructured":"Zhao, D. L. et al. High-resolution MRI of the vessel wall in patients with symptomatic atherosclerotic stenosis of the middle cerebral artery. J Clin Neurosci 22, 700\u2013704 (2015).","journal-title":"J Clin Neurosci"},{"key":"BFsrep38534_CR16","doi-asserted-by":"publisher","first-page":"818","DOI":"10.1161\/01.STR.0000204638.91099.91","volume":"37","author":"N Takaya","year":"2006","unstructured":"Takaya, N. et al. Association between carotid plaque characteristics and subsequent ischemic cerebrovascular events: a prospective assessment with MRI\u2013initial results. Stroke 37, 818\u2013823 (2006).","journal-title":"Stroke"},{"key":"BFsrep38534_CR17","doi-asserted-by":"publisher","first-page":"1200","DOI":"10.3174\/ajnr.A0997","volume":"29","author":"T Ohara","year":"2008","unstructured":"Ohara, T. et al. Eccentric stenosis of the carotid artery associated with ipsilateral cerebrovascular events. AJNR Am J Neuroradiol 29, 1200\u20131203 (2008).","journal-title":"AJNR Am J Neuroradiol"},{"key":"BFsrep38534_CR18","doi-asserted-by":"publisher","first-page":"1567","DOI":"10.1161\/STROKEAHA.115.009037","volume":"46","author":"M Mossa-Basha","year":"2015","unstructured":"Mossa-Basha, M. et al. Multicontrast high-resolution vessel wall magnetic resonance imaging and its value in differentiating intracranial vasculopathic processes. Stroke 46, 1567\u20131573 (2015).","journal-title":"Stroke"},{"key":"BFsrep38534_CR19","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1161\/STROKEAHA.114.008181","volume":"46","author":"SH Ahn","year":"2015","unstructured":"Ahn, S. H. et al. Isolated MCA disease in patients without significant atherosclerotic risk factors: a high-resolution magnetic resonance imaging study. Stroke 46, 697\u2013703 (2015).","journal-title":"Stroke"},{"key":"BFsrep38534_CR20","doi-asserted-by":"publisher","first-page":"1797","DOI":"10.1161\/STROKEAHA.116.013007","volume":"47","author":"N Dieleman","year":"2016","unstructured":"Dieleman, N. et al. Magnetic Resonance Imaging of Plaque Morphology, Burden, and Distribution in Patients With Symptomatic Middle Cerebral Artery Stenosis. Stroke 47, 1797\u20131802 (2016).","journal-title":"Stroke"},{"key":"BFsrep38534_CR21","doi-asserted-by":"publisher","first-page":"2815","DOI":"10.1161\/STROKEAHA.115.010894","volume":"46","author":"S Ryoo","year":"2015","unstructured":"Ryoo, S., Lee, M. J., Cha, J., Jeon, P. & Bang, O. Y. Differential Vascular Pathophysiologic Types of Intracranial Atherosclerotic Stroke: A High-Resolution Wall Magnetic Resonance Imaging Study. Stroke 46, 2815\u20132821 (2015).","journal-title":"Stroke"},{"key":"BFsrep38534_CR22","doi-asserted-by":"publisher","first-page":"1405","DOI":"10.1161\/STROKEAHA.110.583534","volume":"41","author":"IF Klein","year":"2010","unstructured":"Klein, I. F. et al. Basilar artery atherosclerotic plaques in paramedian and lacunar pontine infarctions: a high-resolution MRI study. Stroke 41, 1405\u20131409 (2010).","journal-title":"Stroke"},{"key":"BFsrep38534_CR23","doi-asserted-by":"publisher","first-page":"1527","DOI":"10.1161\/STROKEAHA.116.013122","volume":"47","author":"JW Chung","year":"2016","unstructured":"Chung, J. W. et al. Echoing Plaque Activity of the Coronary and Intracranial Arteries in Patients With Stroke. Stroke 47, 1527\u20131533 (2016).","journal-title":"Stroke"},{"key":"BFsrep38534_CR24","doi-asserted-by":"publisher","first-page":"1789","DOI":"10.1161\/STROKEAHA.116.013495","volume":"47","author":"JW Chung","year":"2016","unstructured":"Chung, J. W., Hwang, J., Lee, M. J., Cha, J. & Bang, O. Y. Previous Statin Use and High-Resolution Magnetic Resonance Imaging Characteristics of Intracranial Atherosclerotic Plaque: The Intensive Statin Treatment in Acute Ischemic Stroke Patients With Intracranial Atherosclerosis Study. Stroke 47, 1789\u20131796 (2016).","journal-title":"Stroke"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/srep38534.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/srep38534","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/srep38534.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,5]],"date-time":"2023-01-05T00:29:48Z","timestamp":1672878588000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/srep38534"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12,5]]},"references-count":24,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2016,12,23]]}},"alternative-id":["BFsrep38534"],"URL":"https:\/\/doi.org\/10.1038\/srep38534","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,12,5]]},"assertion":[{"value":"21 June 2016","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 November 2016","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 December 2016","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing financial interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"38534"}}