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Adult male Sprague-Dawley rats with a stainless-steel cannula in the NTS were used. Aldosterone was injected into the NTS at the doses of 1, 5, 10 and 20\u2009ng 0.1\u2009\u03bcl<jats:sup>\u22121<\/jats:sup>. A rapid dose-related increase of 0.3\u2009M NaCl intake was induced within 30\u2009min and this increase was not suppressed by the mineralocorticoid receptor (MR) antagonist spironolactone (10\u2009ng 0.1\u2009\u03bcl<jats:sup>\u22121<\/jats:sup>). Water intake was not affected by aldosterone. The GPER agonist G-1 produced a parallel and significant increase in sodium intake, while pre-treatment with GPER antagonist G15 (10\u2009ng 0.1\u2009\u03bcl<jats:sup>\u22121<\/jats:sup>) blocked the G-1 or aldosterone-induced rapid sodium intake. In addition, sodium intake induced by sodium depletion or low-sodium diet fell within 30\u2009min after injection into the NTS of the MR antagonist spironolactone, while G15 had no effect. Our results confirm previous reports, and support the hypothesis that aldosterone evokes rapid sodium intake through a non-genomic mechanism involving GPER in NTS.<\/jats:p>","DOI":"10.1038\/srep38631","type":"journal-article","created":{"date-parts":[[2016,12,9]],"date-time":"2016-12-09T10:27:49Z","timestamp":1481279269000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Aldosterone induces rapid sodium intake by a nongenomic mechanism in the nucleus tractus solitarius"],"prefix":"10.1038","volume":"6","author":[{"given":"Hu","family":"Qiao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianqun","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ru","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,12,9]]},"reference":[{"key":"BFsrep38631_CR1","doi-asserted-by":"publisher","first-page":"R14","DOI":"10.1152\/ajpregu.00100.2003","volume":"285","author":"O Skott","year":"2003","unstructured":"Skott, O. 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