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We hypothesised that circumferential strain using deformation-tracking has comparable diagnostic performance to a validated method (Displacement Encoding with Stimulated Echoes- DENSE) and potentially diagnostically superior to an established cine-strain method (feature-tracking). 81 healthy adults (44.6\u2009\u00b1\u200917.7 years old, 47% male), without any history of cardiovascular disease, underwent CMR at 1.5\u2009T including cine, DENSE, and late gadolinium enhancement in subjects &gt;45 years. Acquisitions were divided into 6 segments, and global and segmental peak circumferential strain were derived and analysed by age and sex. Peak circumferential strain differed between the 3 groups (DENSE: \u221219.4\u2009\u00b1\u20094.8%; deformation-tracking: \u221216.8\u2009\u00b1\u20092.4%; feature-tracking: \u221228.7\u2009\u00b1\u20094.8%) (ANOVA with Tukey post-hoc, F-value 279.93, p\u2009&lt;\u20090.01). DENSE and deformation-tracking had better reproducibility than feature-tracking. Intra-class correlation co-efficient was &gt;0.90. Larger magnitudes of strain were detected in women using deformation-tracking and DENSE, but not feature-tracking. Compared with a reference method (DENSE), deformation-tracking using cine imaging has similar diagnostic performance for circumferential strain assessment in healthy individuals. Deformation-tracking could potentially obviate the need for bespoke strain sequences, reducing scanning time and is more reproducible than feature-tracking.<\/jats:p>","DOI":"10.1038\/srep38774","type":"journal-article","created":{"date-parts":[[2016,12,12]],"date-time":"2016-12-12T10:32:40Z","timestamp":1481538760000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["A Novel Method for Estimating Myocardial Strain: Assessment of Deformation Tracking Against Reference Magnetic Resonance Methods in Healthy Volunteers"],"prefix":"10.1038","volume":"6","author":[{"given":"Kenneth","family":"Mangion","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christie","family":"McComb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Carrick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Clerfond","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaodong","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyu","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline E.","family":"Haig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin","family":"Berry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,12,12]]},"reference":[{"key":"BFsrep38774_CR1","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1016\/j.nuclcard.2007.07.006","volume":"14","author":"FH Epstein","year":"2007","unstructured":"Epstein, F. 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The University of Glasgow holds a research agreement with Siemens Healthcare, who provided the DENSE work-in-progress CMR sequence and data analysis software. The other authors declare no competing financial interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"38774"}}