{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T14:17:35Z","timestamp":1761401855464},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2016,12,15]],"date-time":"2016-12-15T00:00:00Z","timestamp":1481760000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2016,12,15]],"date-time":"2016-12-15T00:00:00Z","timestamp":1481760000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Repetitive movements at a constant rate require the integration of internal time counting and motor neural networks. Previous studies have proved that humans can follow short durations automatically (automatic timing) but require more cognitive efforts to track or estimate long durations. In this study, we studied sensorimotor oscillatory activities in healthy subjects and chronic stroke patients when subjects were performing repetitive finger movements. We found the movement-modulated changes in alpha and beta oscillatory activities were decreased with the increase of movement rates in finger lifting of healthy subjects and the non-paretic hands in stroke patients, whereas no difference was found in the paretic-hand movements at different movement rates in stroke patients. The significant difference in oscillatory activities between movements of non-paretic hands and paretic hands could imply the requirement of higher cognitive efforts to perform fast repetitive movements in paretic hands. The sensorimotor oscillatory response in fast repetitive movements could be a possible indicator to probe the recovery of motor function in stroke patients.<\/jats:p>","DOI":"10.1038\/srep39046","type":"journal-article","created":{"date-parts":[[2016,12,15]],"date-time":"2016-12-15T13:42:04Z","timestamp":1481809324000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Study of Repetitive Movements Induced Oscillatory Activities in Healthy Subjects and Chronic Stroke Patients"],"prefix":"10.1038","volume":"6","author":[{"given":"Chuan-Chih","family":"Hsu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wai-Keung","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kuo-Kai","family":"Shyu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hsiao-Huang","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ting-Kuang","family":"Yeh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao-Teng","family":"Hsu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun-Yen","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gong-Yau","family":"Lan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Po-Lei","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2016,12,15]]},"reference":[{"key":"BFsrep39046_CR1","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1038\/nrn1764","volume":"6","author":"CV Buhusi","year":"2005","unstructured":"Buhusi, C. V. & Meck, W. H. What makes us tick? Functional and neural mechanisms of interval timing. Nature Reviews Neuroscience 6, 755\u2013765 (2005).","journal-title":"Nature Reviews Neuroscience"},{"key":"BFsrep39046_CR2","doi-asserted-by":"crossref","unstructured":"Gavazzi, G., Bisio, A. & Pozzo, T. Time perception of visual motion is tuned by the motor representation of human actions. Scientific reports 3 (2013).","DOI":"10.1038\/srep01168"},{"key":"BFsrep39046_CR3","doi-asserted-by":"publisher","first-page":"14803","DOI":"10.1523\/JNEUROSCI.3222-09.2009","volume":"29","author":"B Morillon","year":"2009","unstructured":"Morillon, B., Kell, C. A. & Giraud, A.-L. Three stages and four neural systems in time estimation. The Journal of Neuroscience 29, 14803\u201314811 (2009).","journal-title":"The Journal of Neuroscience"},{"key":"BFsrep39046_CR4","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/S1364-6613(97)01008-5","volume":"1","author":"E P\u00f6ppel","year":"1997","unstructured":"P\u00f6ppel, E. A hierarchical model of temporal perception. Trends in cognitive sciences 1, 56\u201361 (1997).","journal-title":"Trends in cognitive sciences"},{"key":"BFsrep39046_CR5","doi-asserted-by":"publisher","first-page":"1257","DOI":"10.1016\/S0042-6989(00)00235-2","volume":"41","author":"G Pfurtscheller","year":"2001","unstructured":"Pfurtscheller, G. Functional brain imaging based on ERD\/ERS. Vision research 41, 1257\u20131260 (2001).","journal-title":"Vision research"},{"key":"BFsrep39046_CR6","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1146\/annurev.neuro.29.051605.112819","volume":"29","author":"ME Raichle","year":"2006","unstructured":"Raichle, M. E. & Mintun, M. A. Brain work and brain imaging. Annu. Rev. Neurosci. 29, 449\u2013476 (2006).","journal-title":"Annu. Rev. Neurosci."},{"key":"BFsrep39046_CR7","doi-asserted-by":"publisher","first-page":"1842","DOI":"10.1016\/S1388-2457(99)00141-8","volume":"110","author":"G Pfurtscheller","year":"1999","unstructured":"Pfurtscheller, G. & Da Silva, F. L. Event-related EEG\/MEG synchronization and desynchronization: basic principles. Clinical neurophysiology 110, 1842\u20131857 (1999).","journal-title":"Clinical neurophysiology"},{"key":"BFsrep39046_CR8","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/S0166-2236(96)10065-5","volume":"20","author":"R Hari","year":"1997","unstructured":"Hari, R. & Salmelin, R. Human cortical oscillations: a neuromagnetic view through the skull. Trends in neurosciences 20, 44\u201349 (1997).","journal-title":"Trends in neurosciences"},{"key":"BFsrep39046_CR9","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1016\/0013-4694(95)00192-1","volume":"98","author":"P Clochon","year":"1996","unstructured":"Clochon, P., Fontbonne, J.-M., Lebrun, N. & Et\u00e9venon, P. A new method for quantifying eeg event-related desynchronization: amplitude evvelope analysis. Electroencephalography and clinical neurophysiology 98, 126\u2013129 (1996).","journal-title":"Electroencephalography and clinical neurophysiology"},{"key":"BFsrep39046_CR10","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/S0165-0270(00)00350-2","volume":"105","author":"E M\u00f6ller","year":"2001","unstructured":"M\u00f6ller, E., Schack, B., Arnold, M. & Witte, H. Instantaneous multivariate EEG coherence analysis by means of adaptive high-dimensional autoregressive models. Journal of neuroscience methods 105, 143\u2013158 (2001).","journal-title":"Journal of neuroscience methods"},{"key":"BFsrep39046_CR11","doi-asserted-by":"publisher","first-page":"2521","DOI":"10.1016\/j.clinph.2006.06.720","volume":"117","author":"JLW Bosboom","year":"2006","unstructured":"Bosboom, J. L. W. et al. Resting state oscillatory brain dynamics in Parkinson\u2019s disease: an MEG study. Clinical Neurophysiology 117, 2521\u20132531 (2006).","journal-title":"Clinical Neurophysiology"},{"key":"BFsrep39046_CR12","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1097\/00004691-199805000-00008","volume":"15","author":"G Pfurtscheller","year":"1998","unstructured":"Pfurtscheller, G., Pichler-Zalaudek, K., Ortmayr, B. & Diez, J. Postmovement beta synchronization in patients with Parkinson\u2019s disease. Journal of clinical neurophysiology 15, 243\u2013250 (1998).","journal-title":"Journal of clinical neurophysiology"},{"key":"BFsrep39046_CR13","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1006\/nimg.2000.0660","volume":"12","author":"T Sil\u00e9n","year":"2000","unstructured":"Sil\u00e9n, T., Forss, N., Jensen, O. & Hari, R. Abnormal reactivity of the\u223c 20-Hz motor cortex rhythm in Unverricht Lundborg type progressive myoclonus epilepsy. Neuroimage 12, 707\u2013712 (2000).","journal-title":"Neuroimage"},{"key":"BFsrep39046_CR14","doi-asserted-by":"publisher","first-page":"2053","DOI":"10.1152\/jn.00345.2014","volume":"112","author":"HE Rossiter","year":"2014","unstructured":"Rossiter, H. E., Boudrias, M.-H. & Ward, N. S. Do movement-related beta oscillations change after stroke? Journal of neurophysiology 112, 2053\u20132058 (2014).","journal-title":"Journal of neurophysiology"},{"key":"BFsrep39046_CR15","doi-asserted-by":"publisher","first-page":"2204","DOI":"10.1161\/01.STR.25.11.2204","volume":"25","author":"S Giaquinto","year":"1994","unstructured":"Giaquinto, S., Cobianchi, A., Macera, F. & Nolfe, G. EEG recordings in the course of recovery from stroke. Stroke 25, 2204\u20132209 (1994).","journal-title":"Stroke"},{"key":"BFsrep39046_CR16","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1016\/j.neuroimage.2005.05.051","volume":"28","author":"F Tecchio","year":"2005","unstructured":"Tecchio, F. et al. Rhythmic brain activity at rest from rolandic areas in acute mono-hemispheric stroke: a magnetoencephalographic study. Neuroimage 28, 72\u201383 (2005).","journal-title":"Neuroimage"},{"key":"BFsrep39046_CR17","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.neulet.2010.10.072","volume":"488","author":"M St\u0119pie\u0144","year":"2011","unstructured":"St\u0119pie\u0144, M. et al. Event-related desynchronization of sensorimotor EEG rhythms in hemiparetic patients with acute stroke. Neuroscience letters 488, 17\u201321 (2011).","journal-title":"Neuroscience letters"},{"key":"BFsrep39046_CR18","doi-asserted-by":"publisher","first-page":"3377","DOI":"10.1152\/jn.00281.2002","volume":"88","author":"K Toma","year":"2002","unstructured":"Toma, K. et al. Movement rate effect on activation and functional coupling of motor cortical areas. Journal of neurophysiology 88, 3377\u20133385 (2002).","journal-title":"Journal of neurophysiology"},{"key":"BFsrep39046_CR19","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1097\/01.wnr.0000198954.15692.07","volume":"17","author":"Y-Z Wu","year":"2006","unstructured":"Wu, Y.-Z. et al. Effects of cognitive demands on postmovement motor cortical deactivation. Neuroreport 17, 371\u2013375 (2006).","journal-title":"Neuroreport"},{"key":"BFsrep39046_CR20","doi-asserted-by":"publisher","first-page":"3338","DOI":"10.1016\/j.neuroimage.2009.11.048","volume":"49","author":"M Bortoletto","year":"2010","unstructured":"Bortoletto, M. & Cunnington, R. Motor timing and motor sequencing contribute differently to the preparation for voluntary movement. Neuroimage 49, 3338\u20133348 (2010).","journal-title":"Neuroimage"},{"key":"BFsrep39046_CR21","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1006\/nimg.2000.0611","volume":"12","author":"M Taniguchi","year":"2000","unstructured":"Taniguchi, M. et al. Movement-related desynchronization of the cerebral cortex studied with spatially filtered magnetoencephalography. Neuroimage 12, 298\u2013306 (2000).","journal-title":"Neuroimage"},{"key":"BFsrep39046_CR22","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1109\/TBME.2006.886855","volume":"54","author":"H Adeli","year":"2007","unstructured":"Adeli, H., Ghosh-Dastidar, S. & Dadmehr, N. A wavelet-chaos methodology for analysis of EEGs and EEG subbands to detect seizure and epilepsy. IEEE Transactions on Biomedical Engineering 54, 205\u2013211 (2007).","journal-title":"IEEE Transactions on Biomedical Engineering"},{"key":"BFsrep39046_CR23","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1016\/j.ijpsycho.2015.02.008","volume":"103","author":"C Babiloni","year":"2015","unstructured":"Babiloni, C. et al. Brain neural synchronization and functional coupling in Alzheimer\u2019s disease as revealed by resting state EEG rhythms. International Journal of Psychophysiology 103, 88\u2013102 (2015).","journal-title":"International Journal of Psychophysiology"},{"key":"BFsrep39046_CR24","doi-asserted-by":"publisher","first-page":"2769","DOI":"10.1161\/STROKEAHA.108.518027","volume":"39","author":"S Oshino","year":"2008","unstructured":"Oshino, S. et al. Ipsilateral motor-related hyperactivity in patients with cerebral occlusive vascular disease. Stroke 39, 2769\u20132775 (2008).","journal-title":"Stroke"},{"key":"BFsrep39046_CR25","doi-asserted-by":"publisher","first-page":"2029","DOI":"10.1093\/cercor\/bhi078","volume":"15","author":"B Ross","year":"2005","unstructured":"Ross, B., Herdman, A. T. & Pantev, C. Right hemispheric laterality of human 40 Hz auditory steady-state responses. Cerebral Cortex 15, 2029\u20132039 (2005).","journal-title":"Cerebral Cortex"},{"key":"BFsrep39046_CR26","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1016\/j.brs.2012.04.007","volume":"6","author":"Y-F Hsu","year":"2013","unstructured":"Hsu, Y.-F. et al. Intermittent theta burst stimulation over ipsilesional primary motor cortex of subacute ischemic stroke patients: a pilot study. Brain stimulation 6, 166\u2013174 (2013).","journal-title":"Brain stimulation"},{"key":"BFsrep39046_CR27","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1177\/155005941104200410","volume":"42","author":"S Silvoni","year":"2011","unstructured":"Silvoni, S. et al. Brain-computer interface in stroke: a review of progress. Clinical EEG and Neuroscience 42, 245\u2013252 (2011).","journal-title":"Clinical EEG and Neuroscience"},{"key":"BFsrep39046_CR28","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/j.brainres.2007.07.014","volume":"1169","author":"N Erbil","year":"2007","unstructured":"Erbil, N. & Ungan, P. Changes in the alpha and beta amplitudes of the central EEG during the onset, continuation, and offset of long-duration repetitive hand movements. Brain research 1169, 44\u201356 (2007).","journal-title":"Brain research"},{"key":"BFsrep39046_CR29","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1016\/S0921-884X(96)96039-7","volume":"102","author":"C Gerloff","year":"1997","unstructured":"Gerloff, C. et al. Steady-state movement-related cortical potentials: a new approach to assessing cortical activity associated with fast repetitive finger movements. Electroencephalography and clinical neurophysiology 102, 106\u2013113 (1997).","journal-title":"Electroencephalography and clinical neurophysiology"},{"key":"BFsrep39046_CR30","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1016\/S0028-3932(01)00111-7","volume":"40","author":"FA Kagerer","year":"2002","unstructured":"Kagerer, F. A., Wittmann, M., Szelag, E. & Steinb\u00fcchel, N. v. Cortical involvement in temporal reproduction: evidence for differential roles of the hemispheres. Neuropsychologia 40, 357\u2013366 (2002).","journal-title":"Neuropsychologia"},{"key":"BFsrep39046_CR31","doi-asserted-by":"publisher","first-page":"752","DOI":"10.1162\/089892998563149","volume":"10","author":"VB Penhune","year":"1998","unstructured":"Penhune, V. B., Zatorre, R. J. & Evans, A. Cerebellar contributions to motor timing: a PET study of auditory and visual rhythm reproduction. Journal of Cognitive Neuroscience 10, 752\u2013765 (1998).","journal-title":"Journal of Cognitive Neuroscience"},{"key":"BFsrep39046_CR32","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.neulet.2010.06.054","volume":"482","author":"EL Stegem\u00f6ller","year":"2010","unstructured":"Stegem\u00f6ller, E. L., Allen, D. P., Simuni, T. & MacKinnon, C. D. Rate-dependent impairments in repetitive finger movements in patients with Parkinson\u2019s disease are not due to peripheral fatigue. Neuroscience letters 482, 1\u20136 (2010).","journal-title":"Neuroscience letters"},{"key":"BFsrep39046_CR33","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/S0304-3940(02)00825-X","volume":"331","author":"M Alegre","year":"2002","unstructured":"Alegre, M. et al. Beta electroencephalograph changes during passive movements: sensory afferences contribute to beta event-related desynchronization in humans. Neuroscience letters 331, 29\u201332 (2002).","journal-title":"Neuroscience letters"},{"key":"BFsrep39046_CR34","doi-asserted-by":"publisher","first-page":"1312","DOI":"10.1111\/j.1468-1331.2006.01550.x","volume":"13","author":"CF Eder","year":"2006","unstructured":"Eder, C. F. et al. Symmetry of post-movement beta-ERS and motor recovery from stroke: a low\u2010resolution EEG pilot study. European journal of neurology 13, 1312\u20131323 (2006).","journal-title":"European journal of neurology"},{"key":"BFsrep39046_CR35","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1016\/j.neuroimage.2003.12.038","volume":"22","author":"JA Agnew","year":"2004","unstructured":"Agnew, J. A., Zeffiro, T. A. & Eden, G. F. Left hemisphere specialization for the control of voluntary movement rate. Neuroimage 22, 289\u2013303 (2004).","journal-title":"Neuroimage"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/srep39046.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/srep39046","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/srep39046.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,5]],"date-time":"2023-01-05T03:21:35Z","timestamp":1672888895000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/srep39046"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12,15]]},"references-count":35,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2016,12,23]]}},"alternative-id":["BFsrep39046"],"URL":"https:\/\/doi.org\/10.1038\/srep39046","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,12,15]]},"assertion":[{"value":"4 July 2016","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 November 2016","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 December 2016","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing financial interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"39046"}}