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Magnetic Resonance Imaging is a widely used imaging tool for cancers in clinics and research. To develop T1-positive and T2-negative dual mode MRI agents for more comprehensive and accurate diagnostic information under hypoxic conditions, a hypoxia-inducible factor-1\u03b1 based aptamer and Mn(II)-modified nanoparticles D-Fe<jats:sub>3<\/jats:sub>O<jats:sub>4<\/jats:sub>@PMn were synthesized and characterized. <jats:italic>In vitro and in vivo<\/jats:italic> studies show that D-Fe<jats:sub>3<\/jats:sub>O<jats:sub>4<\/jats:sub>@PMn NPs are biocompatible and less cytotoxic and can produce significant contrast enhancement in T1- and T2-weighted MR imaging. Furthermore, the D-Fe<jats:sub>3<\/jats:sub>O<jats:sub>4<\/jats:sub>@PMn NPs enable targeted dual-contrast T1- and T2-weighted MR imaging of cancer cells expressing high levels of HIF-1\u03b1 and cancer stem cell-related proteins under hypoxic condition. 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