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The main storage proteins of <jats:italic>B. distachyon<\/jats:italic> are the 7S globulin type proteins and the 11S, 12S seed storage globulins similar to oat and rice. Immunoblot analyses using serum samples from celiac disease patients were carried out followed by the identification of immune-responsive proteins using mass spectrometry. Serum samples from celiac patients on a gluten-free diet, from patients with Crohn\u2019s disease and healthy subjects, were used as controls. The identified proteins with intense serum-IgA reactivity belong to the 7S and 11\u201312S seed globulin family. Structure prediction and epitope predictions analyses confirmed the presence of celiac disease-related linear B cell epitope homologs and the presence of peptide regions with strong HLA-DQ8 and DQ2 binding capabilities. These results highlight that both MHC-II presentation and B cell response may be developed not only to prolamins but also to seed storage globulins. This is the first study of the non-prolamin type seed storage proteins of <jats:italic>Brachypodium<\/jats:italic> from the aspect of the celiac disease.<\/jats:p>","DOI":"10.1038\/srep39876","type":"journal-article","created":{"date-parts":[[2017,1,4]],"date-time":"2017-01-04T10:36:52Z","timestamp":1483526212000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Characterization of globulin storage proteins of a low prolamin cereal species in relation to celiac disease"],"prefix":"10.1038","volume":"7","author":[{"given":"Gy\u00f6ngyv\u00e9r","family":"Gell","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krisztina","family":"Kov\u00e1cs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00e1bor","family":"Veres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilma R.","family":"Korponay-Szab\u00f3","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ang\u00e9la","family":"Juh\u00e1sz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,1,4]]},"reference":[{"key":"BFsrep39876_CR1","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1007\/s00251-012-0599-z","volume":"64","author":"LM Sollid","year":"2012","unstructured":"Sollid, L. 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