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However, experimental identification of m<jats:sup>6<\/jats:sup>A sites is expensive and laborious. Therefore, it is urgent to develop computational methods for reliable prediction of m<jats:sup>6<\/jats:sup>A sites from primary RNA sequences. In the current study, a new method called <jats:bold>RAM-ESVM<\/jats:bold> was developed for detecting m<jats:sup>6<\/jats:sup>A sites from <jats:italic>Saccharomyces cerevisiae<\/jats:italic> transcriptome, which employed ensemble support vector machine classifiers and novel sequence features. The jackknife test results show that RAM-ESVM outperforms single support vector machine classifiers and other existing methods, indicating that it would be a useful computational tool for detecting m<jats:sup>6<\/jats:sup>A sites in <jats:italic>S. cerevisiae<\/jats:italic>. Furthermore, a web server named RAM-ESVM was constructed and could be freely accessible at <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/server.malab.cn\/RAM-ESVM\/\">http:\/\/server.malab.cn\/RAM-ESVM\/<\/jats:ext-link>.<\/jats:p>","DOI":"10.1038\/srep40242","type":"journal-article","created":{"date-parts":[[2017,1,12]],"date-time":"2017-01-12T10:37:17Z","timestamp":1484217437000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":110,"title":["Detecting N6-methyladenosine sites from RNA transcriptomes using ensemble Support Vector Machines"],"prefix":"10.1038","volume":"7","author":[{"given":"Wei","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengwei","family":"Xing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quan","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,1,12]]},"reference":[{"key":"BFsrep40242_CR1","doi-asserted-by":"publisher","first-page":"D195","DOI":"10.1093\/nar\/gkq1028","volume":"39","author":"WA Cantara","year":"2011","unstructured":"Cantara, W. 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