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To address this limitation, we propose mucoadhesive nanostructured microparticles (PLGA\/PEG NM) as a potential carrier for the sinonasal delivery of RSV. In this study, PLGA\/PEG NM released RSV in a sustained manner. Owing to the enlarged specific surface area of the nanostructures, PLGA\/PEG NM had synergistically enhanced mucoadhesiveness and thus showed improved<jats:italic>in vivo<\/jats:italic>retention properties in the sinonasal cavity. Therefore, when tested in a mouse nasal polyp model, PLGA\/PEG NM mitigated polyp formation and restored epithelial integrity better than the control treatments. 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