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To validate this new design, we compared five helical flow inducers with different thread pitches in terms of blood flow patterns in the filter. The vena cava was reconstructed based on computed tomography images. Both the numerical simulation and <jats:italic>in vitro<\/jats:italic> experiment revealed that the helical flow inducer can effectively create a helical flow in the vessel, thereby subduing the filter structure\u2019s adverse disruption to blood flow, and increasing flow-induced shear stress in the filter center. In addition, the smaller thread pitch helical flow inducer reduced the oscillating shear index and relative residence time on the vessel wall. Moreover, we observed that the helical flow inducer in the vena cava could induce flow rotation both in clockwise and counterclockwise directions. In conclusion, the new design of the filter with the smaller thread pitch inducer is advantageous over the traditional filter in terms of improving local hemodynamics, which may reduce thrombosis build-up after deployment.<\/jats:p>","DOI":"10.1038\/srep40724","type":"journal-article","created":{"date-parts":[[2017,1,23]],"date-time":"2017-01-23T12:04:58Z","timestamp":1485173098000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Improvement of hemodynamic performance using novel helical flow vena cava filter design"],"prefix":"10.1038","volume":"7","author":[{"given":"Ying","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yubo","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yubin","family":"Xing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Xing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,1,23]]},"reference":[{"key":"BFsrep40724_CR1","doi-asserted-by":"publisher","first-page":"e87","DOI":"10.1016\/j.ejim.2011.08.023","volume":"22","author":"T Michaelov","year":"2011","unstructured":"Michaelov, T., Blickstein, D., Levy, D., Berliner, S. & Martin, H. 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