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In this study, we performed a comprehensive analysis about the association of rs895819 with gastric cancer risk and prognosis, atrophic gastritis risk, as well as the interactions with environmental factors. A total of 939 gastric cancer patients, 1,067 atrophic gastritis patients and 1,166 healthy controls were screened by direct sequencing and MALDI-TOF-MS. The association of rs895819 with clinical pathological parameters and prognostic survival in 357 gastric cancer patients was also been analyzed. The rs895819 variant genotype increased the risk for atrophic gastritis (1.58-fold) and gastric cancer (1.24-fold). While in stratified analysis, the risk effect was demonstrated more significantly in the female, age &gt;60y, <jats:italic>Helicobacter pylori (H. pylori<\/jats:italic>) negative and non-drinker subgroups. Rs895819 and <jats:italic>H. pylori<\/jats:italic> showed an interaction effect for atrophic gastritis risk. In the survival analysis, the rs895819 AG heterozygosis was associated with better survival than the AA wild-type in the TNM stage I\u2013II subgroup. <jats:italic>In vitro<\/jats:italic> study by overexpressing miR-27a, cells carrying polymorphic-type G allele expressed lower miR-27a than wild-type A allele. In conclusion, <jats:italic>miR-27a<\/jats:italic> rs895819 is implicated as a biomarker for gastric cancer and atrophic gastritis risk, and interacts with <jats:italic>H. pylori<\/jats:italic> in gastric carcinogenesis.<\/jats:p>","DOI":"10.1038\/srep41307","type":"journal-article","created":{"date-parts":[[2017,2,2]],"date-time":"2017-02-02T10:23:09Z","timestamp":1486030989000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["MiR-27a rs895819 is involved in increased atrophic gastritis risk, improved gastric cancer prognosis and negative interaction with Helicobacter pylori"],"prefix":"10.1038","volume":"7","author":[{"given":"Qian","family":"Xu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tie-jun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cai-yun","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li-ping","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing-wei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2017,2,2]]},"reference":[{"key":"BFsrep41307_CR1","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1007\/978-1-60327-411-1_1","volume":"578","author":"BS Shastry","year":"2009","unstructured":"Shastry, B. 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