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However, its pharmacodynamic properties have not been systematically studied yet. In this study, the<jats:italic>in vitro<\/jats:italic>antibacterial activities of ADP and its main metabolites were assayed, and the<jats:italic>in vivo<\/jats:italic>antibacterial efficacy of ADP for the treatment of swine streptococcosis was evaluated. It was shown that<jats:italic>Salmonella<\/jats:italic>and<jats:italic>Streptococcus<\/jats:italic>from swine,<jats:italic>Escherichia coli<\/jats:italic>and<jats:italic>Salmonella<\/jats:italic>from chickens,<jats:italic>E. coli, Streptococcus, Mannheimia, Pasteurella<\/jats:italic>from calves,<jats:italic>Streptococcus<\/jats:italic>and<jats:italic>Mannheimia<\/jats:italic>from sheep, and<jats:italic>E. coli, Flavobacterium columnare, Acinetobacter baumannii<\/jats:italic>and<jats:italic>Yersinia ruckeri<\/jats:italic>from fishes were highly susceptible to ADP.<jats:italic>Haemophilus parasuis<\/jats:italic>from swine,<jats:italic>Staphylococcus aureus, Aeromonas punctate, Mycobacterium tuberculosis, Streptococcus agalactiae<\/jats:italic>from fishes, and<jats:italic>Klebsiella<\/jats:italic>from calves and sheep showed moderate susceptibility to ADP, whereas<jats:italic>E. coli, Actinobacillus pleuropneumonia, Pasteurella, S. aureus, Clostridium perfringens<\/jats:italic>from swine,<jats:italic>S. aureus, C. perfringens<\/jats:italic>from chickens, and<jats:italic>S. aureus<\/jats:italic>from calves were resistant to ADP. The main metabolites of ADP showed equal activity to that of their parent compound, and the prevention and therapeutic dosages of ADP recommended for swine streptococcosis were 10 and 20~40\u2009mg\/kg b.w., respectively. 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