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The aim was to analyze the association between <jats:italic>2<\/jats:italic>\u2032<jats:italic>5<\/jats:italic>\u2032<jats:italic>oligoadenylate synthetase 1,2 and 3 (OAS1-3<\/jats:italic>) and <jats:italic>myxovirus resistance proteins 1 (Mx1<\/jats:italic>) polymorphisms and severity of liver disease in human immunodeficiency virus (HIV)\/hepatitis C virus (HCV) coinfected patients. We performed a cross-sectional study in 219 patients that underwent a liver biopsy. DNA genotyping for <jats:italic>Mx1<\/jats:italic> (rs469390), <jats:italic>OAS1<\/jats:italic> (rs2285934), <jats:italic>OAS2<\/jats:italic> (rs1293762) and <jats:italic>OAS3<\/jats:italic> (rs2010604) was performed by using GoldenGate assay. The outcome variables ion liver biopsy were: (i) significant fibrosis (F\u2009\u2265\u20092); (ii) moderate activity grade (A\u2009\u2265\u20092). Additive model of inheritance for genetic association test was used. The likelihood of having significant fibrosis (F\u2009\u2265\u20092) was lower in patients carrying <jats:italic>OAS2<\/jats:italic> rs1293762 A allele [adjusted odds ratio (aOR)\u2009=\u20090.51; p\u2009=\u20090.040]. Besides, the likelihood of having moderate activity grade (A\u2009\u2265\u20092) was higher in patients carrying <jats:italic>Mx1<\/jats:italic> rs464397 C allele (aOR\u2009=\u20091.63; p\u2009=\u20090.028) and <jats:italic>Mx1<\/jats:italic> rs469390 G allele (aOR\u2009=\u20091.97; p\u2009=\u20090.005), while it was lower in patients carrying <jats:italic>OAS1<\/jats:italic> rs2285934 A allele (aOR\u2009=\u20090.64; p\u2009=\u20090.039) and <jats:italic>OAS2<\/jats:italic> rs1293762 A allele (aOR\u2009=\u20090.41; p\u2009=\u20090.009). In conclusion, <jats:italic>Mx1<\/jats:italic> and <jats:italic>OAS1-2<\/jats:italic> polymorphisms were associated with the severity of liver disease in HIV\/HCV-coinfected patients, suggesting a significant role in the progression of hepatic fibrosis.<\/jats:p>","DOI":"10.1038\/srep41516","type":"journal-article","created":{"date-parts":[[2017,1,31]],"date-time":"2017-01-31T10:57:23Z","timestamp":1485860243000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Mx1, OAS1 and OAS2 polymorphisms are associated with the severity of liver disease in HIV\/HCV-coinfected patients: A cross-sectional study"],"prefix":"10.1038","volume":"7","author":[{"given":"M\u00f3nica","family":"Garc\u00eda-\u00c1lvarez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Berenguer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda A.","family":"Jim\u00e9nez-Sousa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Pineda-Tenor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Ald\u00e1miz-Echevarria","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Tejerina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Diez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia","family":"V\u00e1zquez-Mor\u00f3n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvador","family":"Resino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,1,31]]},"reference":[{"key":"BFsrep41516_CR1","doi-asserted-by":"publisher","first-page":"S14","DOI":"10.1016\/j.jhep.2014.06.035","volume":"61","author":"MH Heim","year":"2014","unstructured":"Heim, M. 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