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However, individual studies have produced inconsistent results. We conducted a comprehensive meta-analysis of eleven case-control studies to better understand roles of the four polymorphisms in HT development. The results showed only <jats:italic>FokI<\/jats:italic> polymorphism was significantly associated with the risk of HT (F vs f: OR\u2009=\u20091.44, 95% CI\u2009=\u20091.09\u20131.91, <jats:italic>P<\/jats:italic>\u2009=\u20090.010; FF vs Ff\u2009+\u2009ff: OR\u2009=\u20091.72, 95% CI\u2009=\u20091.09\u20132.70, <jats:italic>P<\/jats:italic>\u2009=\u20090.019). Subgroup analyses demonstrated the significant effect was only present in Asian population (F vs f: OR\u2009=\u20091.45, 95% CI\u2009=\u20091.07\u20131.95, <jats:italic>P<\/jats:italic>\u2009=\u20090.016; FF vs ff: OR\u2009=\u20091.64, 95% CI\u2009=\u20091.03\u20132.59, <jats:italic>P<\/jats:italic>\u2009=\u20090.036; FF\u2009+\u2009Ff vs ff: OR\u2009=\u20091.34, 95% CI\u2009=\u20091.00\u20131.80, <jats:italic>P<\/jats:italic>\u2009=\u20090.047; FF vs Ff\u2009+\u2009ff: OR\u2009=\u20091.64, 95% CI\u2009=\u20091.03\u20132.64, <jats:italic>P<\/jats:italic>\u2009=\u20090.039), but not in Caucasian. For <jats:italic>TaqI, ApaI<\/jats:italic> and <jats:italic>BsmI<\/jats:italic> polymorphisms, no significant association was found in any model comparison. Based on the current literature, it appears that only VDR <jats:italic>FokI<\/jats:italic> polymorphism is associated with HT risk in Asian population, but not in Caucasians; and the <jats:italic>TaqI, ApaI<\/jats:italic> and <jats:italic>BsmI<\/jats:italic> polymorphisms have not positive association neither in the overall population, nor when stratified by ethnicity. Further well-designed studies with larger sample sizes and different ethnic population are needed to clarify the present findings.<\/jats:p>","DOI":"10.1038\/srep41540","type":"journal-article","created":{"date-parts":[[2017,1,30]],"date-time":"2017-01-30T10:17:07Z","timestamp":1485771427000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Vitamin D receptor gene FokI but not TaqI, ApaI, BsmI polymorphism is associated with Hashimoto\u2019s thyroiditis: a meta-analysis"],"prefix":"10.1038","volume":"7","author":[{"given":"Xiaofei","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenli","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingqiang","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,1,30]]},"reference":[{"key":"BFsrep41540_CR1","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1210\/jcem.87.2.8182","volume":"87","author":"JG Hollowell","year":"2002","unstructured":"Hollowell, J. 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