{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T20:09:11Z","timestamp":1791922151496,"version":"4.3.4"},"reference-count":48,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2017,1,30]],"date-time":"2017-01-30T00:00:00Z","timestamp":1485734400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2017,1,30]],"date-time":"2017-01-30T00:00:00Z","timestamp":1485734400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Basophils are rare, circulating granulocytes proposed to be involved in T helper (T\n                    <jats:sub>H<\/jats:sub>\n                    ) type 2 immunity, mainly through secretion of interleukin (IL)-4. In addition to IL-4, basophils produce IL-6 and tumor necrosis factor (TNF)-\u03b1 in response to immunoglobulin E (IgE) crosslinking. Differentiation of T\n                    <jats:sub>H<\/jats:sub>\n                    17 cells requires IL-6 and transforming growth factor (TGF)-\u03b2, but whether basophils play a significant role in T\n                    <jats:sub>H<\/jats:sub>\n                    17 induction is unknown. Here we show a role for basophils in T\n                    <jats:sub>H<\/jats:sub>\n                    17 cell development by using\n                    <jats:italic>in vitro<\/jats:italic>\n                    T cell differentiation and\n                    <jats:italic>in vivo<\/jats:italic>\n                    T\n                    <jats:sub>H<\/jats:sub>\n                    17-mediated inflammation models. Bone marrow derived-basophils (BMBs) and splenic basophils produce significant amounts of IL-6 as well as IL-4 following stimulation with IgE crosslink or cholera toxin (CT). In addition, through IL-6 secretion, BMBs cooperate with dendritic cells to promote T\n                    <jats:sub>H<\/jats:sub>\n                    17 cell differentiation. In the T\n                    <jats:sub>H<\/jats:sub>\n                    17 lung inflammation model, basophils are recruited to the inflamed lungs following CT challenge, and T\n                    <jats:sub>H<\/jats:sub>\n                    17 responses are significantly reduced in the absence of basophils or IL-6. Furthermore, reconstitution with wild-type, but not IL-6-deficient, basophils restored CT-mediated lung inflammation. Lastly, basophil-deficient mice showed reduced phenotypes of T\n                    <jats:sub>H<\/jats:sub>\n                    17-dependent experimental autoimmune encephalomyelitis. Therefore, our results indicate that basophils are an important inducer of T\n                    <jats:sub>H<\/jats:sub>\n                    17 cell differentiation, which is dependent on IL-6 secretion.\n                  <\/jats:p>","DOI":"10.1038\/srep41744","type":"journal-article","created":{"date-parts":[[2017,1,30]],"date-time":"2017-01-30T05:18:32Z","timestamp":1485753512000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":53,"title":["Basophil-derived IL-6 regulates TH17 cell differentiation and CD4 T cell immunity"],"prefix":"10.1038","volume":"7","author":[{"given":"Chae Min","family":"Yuk","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyeung Ju","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo-In","family":"Kwon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang Joon","family":"Lah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji-Young","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyung-Mi","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Su-Hyung","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seokchan","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung-Hyo","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,1,30]]},"reference":[{"key":"BFsrep41744_CR1","doi-asserted-by":"publisher","first-page":"726","DOI":"10.1016\/j.immuni.2007.06.004","volume":"26","author":"H Iwasaki","year":"2007","unstructured":"Iwasaki, H. & Akashi, K. Myeloid lineage commitment from the hematopoietic stem cell. Immunity 26, 726\u2013740, doi: 10.1016\/j.immuni.2007.06.004 (2007).","journal-title":"Immunity"},{"key":"BFsrep41744_CR2","doi-asserted-by":"publisher","first-page":"1333","DOI":"10.1038\/ni.f.217","volume":"9","author":"B Min","year":"2008","unstructured":"Min, B. Basophils: what they \u2018can do\u2019 versus what they \u2018actually do\u2019. Nature immunology 9, 1333\u20131339, doi: 10.1038\/ni.f.217 (2008).","journal-title":"Nature immunology"},{"key":"BFsrep41744_CR3","doi-asserted-by":"publisher","first-page":"936","DOI":"10.1258\/0007142001903616","volume":"56","author":"J Wedemeyer","year":"2000","unstructured":"Wedemeyer, J. & Galli, S. J. Mast cells and basophils in acquired immunity. 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Role for interleukin-3 in mast-cell and basophil development and in immunity to parasites. Nature 392, 90\u201393, doi: 10.1038\/32190 (1998).","journal-title":"Nature"},{"key":"BFsrep41744_CR8","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1038\/ni.1621","volume":"9","author":"A Denzel","year":"2008","unstructured":"Denzel, A. et al. Basophils enhance immunological memory responses. Nature immunology 9, 733\u2013742, doi: 10.1038\/ni.1621 (2008).","journal-title":"Nature immunology"},{"key":"BFsrep41744_CR9","doi-asserted-by":"publisher","first-page":"5542","DOI":"10.1073\/pnas.86.14.5542","volume":"86","author":"P Valent","year":"1989","unstructured":"Valent, P. et al. Interleukin 3 activates human blood basophils via high-affinity binding sites. 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