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Its prevention continues to pose a challenge. A 70-KDa glycoprotein (Gp70) of <jats:italic>Sporothrix<\/jats:italic> has been previously reported to protect host against infection from this fungus. Here, we displayed an epitope peptide (kpvqhalltplgldr) of Gp70 on the major coat protein (pIII), and investigated its efficiency as a vaccine for preventing <jats:italic>S. globosa<\/jats:italic> infection. The recombinant phage and the heat-killed <jats:italic>S. globosa<\/jats:italic> were used to immunize mice separately. In this study, we evaluated the humoral and cellular immune responses in the mice and demonstrated that recombinant phage could induce mice to produce a stronger immune response and generate antibodies to inhibit <jats:italic>S. globosa<\/jats:italic> infection. Furthermore, immunization with recombinant phage could increase the survival rate of <jats:italic>S. globosa<\/jats:italic> infection in mice. All these results together indicated that recombinant phages displaying kpvqhalltplgldr are a potential vaccine candidate against <jats:italic>S. globosa<\/jats:italic> infection.<\/jats:p>","DOI":"10.1038\/srep42024","type":"journal-article","created":{"date-parts":[[2017,2,6]],"date-time":"2017-02-06T10:56:36Z","timestamp":1486378596000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Recombinant Phage Elicits Protective Immune Response against Systemic S. globosa Infection in Mouse Model"],"prefix":"10.1038","volume":"7","author":[{"given":"Feng","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rihua","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yicun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingji","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuai","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongxi","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,2,6]]},"reference":[{"key":"BFsrep42024_CR1","doi-asserted-by":"publisher","first-page":"696","DOI":"10.1136\/jnnp.2009.173187","volume":"81","author":"MC Galhardo","year":"2010","unstructured":"Galhardo, M. 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