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Disruption of ion homeostasis can cause inner ear disorders with hearing loss and dizziness, such as Meniere\u2019s disease. Herein, we found, for the first time, functional evidence for the involvement of \u03b2<jats:sub>1<\/jats:sub>- and \u03b2<jats:sub>2<\/jats:sub>-adrenergic receptors in apical electrogenic ion transport by human ES epithelium by using electrophysiological\/pharmacological and molecular biological methods, which were dependent on K<jats:sup>+<\/jats:sup> and Cl<jats:sup>\u2212<\/jats:sup> ion transport. The apical electrogenic transport was absent or very weak in ES epithelia of patients with Meniere\u2019s disease. These results suggested that adrenergic stimulation via \u03b2<jats:sub>1<\/jats:sub>- and \u03b2<jats:sub>2<\/jats:sub>-adrenergic receptors in the human ES was involved in regulation of inner ear fluid ion homeostasis and impairment of this response could be a pathological mechanism of Meniere\u2019s disease.<\/jats:p>","DOI":"10.1038\/srep42217","type":"journal-article","created":{"date-parts":[[2017,2,6]],"date-time":"2017-02-06T10:09:04Z","timestamp":1486375744000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["\u03b21- and \u03b22-adrenergic stimulation-induced electrogenic transport by human endolymphatic sac epithelium and its clinical implications"],"prefix":"10.1038","volume":"7","author":[{"given":"Bo Gyung","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin Young","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JinSei","family":"Jung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"In Seok","family":"Moon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joo-Heon","family":"Yoon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae Young","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung Huhn","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,2,6]]},"reference":[{"key":"BFsrep42217_CR1","doi-asserted-by":"publisher","first-page":"18110","DOI":"10.1038\/srep18110","volume":"5","author":"SH Kim","year":"2015","unstructured":"Kim, S. 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