{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T23:59:55Z","timestamp":1770508795008,"version":"3.49.0"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2017,2,17]],"date-time":"2017-02-17T00:00:00Z","timestamp":1487289600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2017,2,17]],"date-time":"2017-02-17T00:00:00Z","timestamp":1487289600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>To investigate the efficacy of cervical pessary placement in preventing preterm birth and perinatal morbidity and mortality in asymptomatic women with a singleton pregnancy and a short cervix, we searched literature in relevant databases. The meta-analysis of the 3 included trials (1412 women) showed cervical pessary placement did not reduce the risk of spontaneous preterm birth &lt;34 weeks in these women (risk ratio (RR), 0.71; 95% confidence interval (CI), 0.21\u20132.43, P\u2009=\u20090.59; I<jats:sup>2<\/jats:sup>\u2009=\u200990%). The sensitivity analyses by excluding one trial at one time showed the same results. This meta-analysis also showed that cervical pessary did not prevent preterm birth &lt;34, 30, 28 weeks and was not associated with respiratory distress syndrome, necrotising enterocolitis, intraventricular haemorrhage, neonatal sepsis, retinopathy of prematurity, fetal death, neonatal death, perinatal death, birth weight &lt;1500\u2009g, birth weight &lt;2500\u2009g, premature preterm rupture of membranes, corticosteroid treatment for fetal maturation, and admission to neonatal intensive care unit. Although this meta-analysis showed cervical pessary placement did not reduce the risk of preterm birth in women with a singleton pregnancy and a short cervix, we could not confirm or refute this conclusion, and large-scale randomised controlled trials are urgently needed.<\/jats:p>","DOI":"10.1038\/srep42560","type":"journal-article","created":{"date-parts":[[2017,2,17]],"date-time":"2017-02-17T10:08:06Z","timestamp":1487326086000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Cervical Pessary for Prevention of Preterm Birth: A Meta-Analysis"],"prefix":"10.1038","volume":"7","author":[{"given":"Xin-Hang","family":"Jin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li-Li","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2017,2,17]]},"reference":[{"key":"BFsrep42560_CR1","doi-asserted-by":"publisher","first-page":"2162","DOI":"10.1016\/S0140-6736(12)60820-4","volume":"379","author":"H Blencowe","year":"2012","unstructured":"Blencowe, H. et al. National, regional, and worldwide estimates of preterm birth rates in the year 2010 with time trends since 1990 for selected countries: a systematic analysis and implications. Lancet (London, England) 379, 2162\u20132172 (2012).","journal-title":"Lancet (London, England)"},{"key":"BFsrep42560_CR2","doi-asserted-by":"publisher","first-page":"31","DOI":"10.2471\/BLT.08.062554","volume":"88","author":"S Beck","year":"2010","unstructured":"Beck, S. et al. The worldwide incidence of preterm birth: a systematic review of maternal mortality and morbidity. Bulletin of the World Health Organization 88, 31\u201338, doi: 10.2471\/BLT.08.062554 (2010).","journal-title":"Bulletin of the World Health Organization"},{"key":"BFsrep42560_CR3","doi-asserted-by":"publisher","first-page":"2151","DOI":"10.1016\/S0140-6736(12)60560-1","volume":"379","author":"L Liu","year":"2012","unstructured":"Liu, L. et al. Global, regional, and national causes of child mortality: an updated systematic analysis for 2010 with time trends since 2000. Lancet (London, England) 379, 2151\u20132161, doi: 10.1016\/S0140-6736(12)60560-1 (2012).","journal-title":"Lancet (London, England)"},{"key":"BFsrep42560_CR4","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1016\/S0140-6736(11)61577-8","volume":"379","author":"MK Mwaniki","year":"2012","unstructured":"Mwaniki, M. K., Atieno, M., Lawn, J. E. & Newton, C. R. Long-term neurodevelopmental outcomes after intrauterine and neonatal insults: a systematic review. Lancet (London, England) 379, 445\u2013452, doi: 10.1016\/S0140-6736(11)61577-8 (2012).","journal-title":"Lancet (London, England)"},{"key":"BFsrep42560_CR5","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/S0140-6736(08)60074-4","volume":"371","author":"RL Goldenberg","year":"2008","unstructured":"Goldenberg, R. L., Culhane, J. F., Iams, J. D. & Romero, R. 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