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However, the role and regulatory mechanisms of\n                    <jats:italic>Rheb<\/jats:italic>\n                    in macrophage polarization and allergic asthma are not known. In the present study, we utilized a mouse model with myeloid cell-specific deletion of the\n                    <jats:italic>Rheb1<\/jats:italic>\n                    gene and an ovalbumin (OVA)-induced allergic asthma model to investigate the role of\n                    <jats:italic>Rheb1<\/jats:italic>\n                    in allergic asthma and macrophage polarization. Increased activity of\n                    <jats:italic>Rheb1<\/jats:italic>\n                    and mTORC1 was observed in myeloid cells of C57BL\/6 mice with OVA-induced asthma. In an OVA-induced asthma model,\n                    <jats:italic>Rheb1<\/jats:italic>\n                    -KO mice demonstrated a more serious inflammatory response, more mucus production, enhanced airway hyper-responsiveness, and greater eosinophil numbers in bronchoalveolar lavage fluid (BALF). They also showed increased numbers of bone marrow macrophages and BALF myeloid cells, elevated M2 polarization and reduced M1 polarization of macrophages. Thus, we have established that\n                    <jats:italic>Rheb1<\/jats:italic>\n                    is critical for the polarization of macrophages and inhibition of allergic asthma. Deletion of\n                    <jats:italic>Rheb1<\/jats:italic>\n                    enhances M2 polarization but decreases M1 polarization in alveolar macrophages, leading to the aggravation of OVA-induced allergic asthma.\n                  <\/jats:p>","DOI":"10.1038\/srep42655","type":"journal-article","created":{"date-parts":[[2017,2,22]],"date-time":"2017-02-22T05:34:43Z","timestamp":1487741683000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Rheb1 deletion in myeloid cells aggravates OVA-induced allergic inflammation in mice"],"prefix":"10.1038","volume":"7","author":[{"given":"Kai","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kang Yan","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue Juan","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kang","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao Chun","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cui Lan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,2,22]]},"reference":[{"key":"BFsrep42655_CR1","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1038\/ni0802-715","volume":"3","author":"DT Umetsu","year":"2002","unstructured":"Umetsu, D. 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