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In the stomach, longstanding gastritis often results in structural alterations in the gastric mucosa, including metaplastic changes and gastric cancers. Therefore, it is important to elucidate factors that are involved in gastric inflammation. Nardilysin (N-arginine dibasic convertase; Nrdc) is a metalloendopeptidase of the M16 family that promotes ectodomain shedding of the precursor forms of various growth factors and cytokines by enhancing the protease activities of a disintegrin and metalloproteinase (ADAM) proteins. Here, we have demonstrated that Nrdc crucially regulates gastric inflammation caused by<jats:italic>Helicobacter felis<\/jats:italic>infection or forced expression of prostaglandin E<jats:sub>2<\/jats:sub>in<jats:italic>K19-C2mE<\/jats:italic>mice. Metaplastic changes following gastric inflammation were suppressed by the deletion of<jats:italic>Nrdc<\/jats:italic>. Furthremore, the deletion of<jats:italic>Nrdc<\/jats:italic>significantly suppressed<jats:italic>N<\/jats:italic>-methyl-<jats:italic>N<\/jats:italic>-nitrosourea (MNU)-induced gastric tumorigenesis in the murine stomach. These data may lead to a global therapeutic approach against various gastric disorders by targeting Nrdc.<\/jats:p>","DOI":"10.1038\/srep43052","type":"journal-article","created":{"date-parts":[[2017,2,23]],"date-time":"2017-02-23T10:21:44Z","timestamp":1487845304000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Nardilysin regulates inflammation, metaplasia, and tumors in murine stomach"],"prefix":"10.1038","volume":"7","author":[{"given":"Yuto","family":"Kimura","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kozo","family":"Ikuta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Kimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsutomu","family":"Chiba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroko","family":"Oshima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masanobu","family":"Oshima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eiichiro","family":"Nishi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Seno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,2,23]]},"reference":[{"key":"BFsrep43052_CR1","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1111\/j.1365-2036.1995.tb00390.x","volume":"9","author":"RE Pounder","year":"1995","unstructured":"Pounder, R. 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