{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T14:12:04Z","timestamp":1792419124071,"version":"4.5.0"},"reference-count":70,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2017,2,22]],"date-time":"2017-02-22T00:00:00Z","timestamp":1487721600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2017,2,22]],"date-time":"2017-02-22T00:00:00Z","timestamp":1487721600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Neuroimaging evidence implicates the association between rumination and default mode network (DMN) in major depressive disorder (MDD). However, the relationship between rumination and DMN subsystems remains incompletely understood, especially in patients with MDD. Thirty-three first-episode drug-naive patients with MDD and thirty-three healthy controls (HCs) were enrolled and underwent resting-sate fMRI scanning. Functional connectivity analysis was performed based on 11 pre-defined regions of interest (ROIs) for three DMN subsystems: the midline core, dorsal medial prefrontal cortex (dMPFC) and medial temporal lobe (MTL). Compared with HCs group, patients with MDD exhibited increased within-system connectivity in the dMPFC subsystem and inter-system connectivity between the dMPFC and MTL subsystems. Decreased inter-system connectivity was identified between the midline core and dMPFC subsystem in MDD patients. Depressive rumination was positively correlated with within-system connectivity in the dMPFC subsystem (dMPFC-TempP) and with inter-system connectivity between the dMPFC and MTL subsystems (LTC-PHC). Our results suggest MDD may be characterized by abnormal DMN subsystems connectivity, which may contribute to the pathophysiology of the maladaptive self-focus in MDD patients.<\/jats:p>","DOI":"10.1038\/srep43105","type":"journal-article","created":{"date-parts":[[2017,2,22]],"date-time":"2017-02-22T05:59:18Z","timestamp":1487743158000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":90,"title":["Rumination and Default Mode Network Subsystems Connectivity in First-episode, Drug-Naive Young Patients with Major Depressive Disorder"],"prefix":"10.1038","volume":"7","author":[{"given":"Xueling","family":"Zhu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuling","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huaizhen","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weihua","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fulai","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,2,22]]},"reference":[{"key":"BFsrep43105_CR1","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1037\/0021-843X.100.4.569","volume":"100","author":"S Nolenhoeksema","year":"1991","unstructured":"Nolenhoeksema, S. Responses to depression and their effects on the duration of depressive episodes. J Abnorm Psychol. 100, 569\u2013582 (1991).","journal-title":"J Abnorm Psychol"},{"key":"BFsrep43105_CR2","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1111\/j.1745-6924.2008.00088.x","volume":"3","author":"S Nolen-Hoeksema","year":"2008","unstructured":"Nolen-Hoeksema, S., Wisco, B. E. & Lyubomirsky, S. Rethinking Rumination. Perspect Psychol Sci. 3, 400\u2013424 (2008).","journal-title":"Perspect Psychol Sci"},{"key":"BFsrep43105_CR3","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1037\/0033-2909.128.4.638","volume":"128","author":"N Mor","year":"2002","unstructured":"Mor, N. & Winquist, J. Self-focused attention and negative affect: A meta-analysis. Psychol Bull. 128, 638\u2013662 (2002).","journal-title":"Psychol Bull."},{"key":"BFsrep43105_CR4","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1037\/0021-843X.109.3.504","volume":"109","author":"S Nolen-Hoeksema","year":"2000","unstructured":"Nolen-Hoeksema, S. The role of rumination in depressive disorders and mixed anxiety\/depressive symptoms. J Abnorm Psychol. 109, 504\u2013511 (2000).","journal-title":"J Abnorm Psychol"},{"key":"BFsrep43105_CR5","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1037\/0033-2909.134.2.163","volume":"134","author":"ER Watkins","year":"2008","unstructured":"Watkins, E. R. Constructive and unconstructive repetitive thought. Psychol Bull. 134, 163\u2013206 (2008).","journal-title":"Psychol Bull."},{"key":"BFsrep43105_CR6","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1023\/A:1018713313894","volume":"22","author":"JE Roberts","year":"1998","unstructured":"Roberts, J. E., Gilboa, E. & Gotlib, I. H. Ruminative response style and vulnerability to episodes of dysphoria: gender, neuroticism, and episode duration. Cognit. Ther. Res. 22, 401\u2013423 (1998).","journal-title":"Cognit. Ther. Res"},{"key":"BFsrep43105_CR7","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.biopsych.2011.05.018","volume":"70","author":"J Zhang","year":"2011","unstructured":"Zhang, J. et al. Disrupted Brain Connectivity Networks in Drug-Naive, First-Episode Major Depressive Disorder. Biol. Psychiatry. 70, 334\u2013342 (2011).","journal-title":"Biol. Psychiatry."},{"key":"BFsrep43105_CR8","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.nbd.2012.01.015","volume":"52","author":"JP Hamilton","year":"2013","unstructured":"Hamilton, J. P., Chen, M. C. & Gotlib, I. H. Neural systems approaches to understanding major depressive disorder: an intrinsic functional organization perspective. Neurobiol. Dis. 52, 4\u201311 (2013).","journal-title":"Neurobiol. Dis."},{"key":"BFsrep43105_CR9","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/S1052-5149(03)00104-7","volume":"13","author":"HS Mayberg","year":"2003","unstructured":"Mayberg, H. S. Positron emission tomography imaging in depression: a neural systems perspective. Neuroimaging Clin. N. Am. 13, 805\u2013815 (2003).","journal-title":"Neuroimaging Clin. N. Am."},{"key":"BFsrep43105_CR10","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/s00429-008-0189-x","volume":"213","author":"WC Drevets","year":"2008","unstructured":"Drevets, W. C., Price, J. L. & Furey, M. L. Brain structural and functional abnormalities in mood disorders: implications for neurocircuitry models of depression. Brain Struct Funct. 213, 1\u20132, 93\u2013118 (2008).","journal-title":"Brain Struct Funct"},{"key":"BFsrep43105_CR11","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1073\/pnas.98.2.676","volume":"98","author":"ME Raichle","year":"2001","unstructured":"Raichle, M. E. et al. A default mode of brain function. Proc Natl Acad Sci USA 98, 676\u2013682 (2001).","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFsrep43105_CR12","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1073\/pnas.0135058100","volume":"100","author":"MD Greicius","year":"2003","unstructured":"Greicius, M. D., Krasnow, B., Reiss, A. L. & Menon, V. Functional connectivity in the resting brain: A network analysis of the default mode hypothesis. Proc Natl Acad Sci USA 100, 253\u2013258 (2003).","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFsrep43105_CR13","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/j.neuroimage.2005.12.002","volume":"31","author":"G Northoff","year":"2006","unstructured":"Northoff, G. et al. Self-referential processing in our brain\u2014a meta-analysis of imaging studies on the self. NeuroImage. 31, 440\u2013457 (2006).","journal-title":"NeuroImage"},{"key":"BFsrep43105_CR14","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1111\/nyas.12360","volume":"1316","author":"JR Andrews-Hanna","year":"2014","unstructured":"Andrews-Hanna, J. R., Smallwood, J. & Spreng, R. N. The default network and self-generated thought: component processes, dynamic control, and clinical relevance. Ann NY Acad Sci. 1316, 29\u201352 (2014).","journal-title":"Ann NY Acad Sci"},{"key":"BFsrep43105_CR15","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.neubiorev.2008.09.002","volume":"33","author":"SJ Broyd","year":"2009","unstructured":"Broyd, S. J. et al. Default-mode brain dysfunction in mental disorders: A systematic review. Neurosci Biobehav Rev. 33, 279\u2013296 (2009).","journal-title":"Neurosci Biobehav Rev"},{"key":"BFsrep43105_CR16","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/j.nlm.2011.06.006","volume":"96","author":"JW Murrough","year":"2011","unstructured":"Murrough, J. W., Iacoviello, B., Neumeister, A., Charney, D. S. & Iosifescu, D. V. Cognitive dysfunction in depression: neurocircuitry and new therapeutic strategies. Neurobiol Learn Mem. 96, 553\u2013563 (2011).","journal-title":"Neurobiol Learn Mem"},{"key":"BFsrep43105_CR17","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1016\/j.biopsych.2005.02.021","volume":"57","author":"A Anand","year":"2005","unstructured":"Anand, A. et al. Activity and connectivity of brain mood regulating circuit in depression: a functional magnetic resonance study. Biol. Psychiatry. 57, 1079\u20131088 (2005).","journal-title":"Biol. Psychiatry."},{"key":"BFsrep43105_CR18","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1038\/npp.2008.81","volume":"34","author":"S Grimm","year":"2009","unstructured":"Grimm, S. et al. Altered negative BOLD responses in the default-mode network during emotion processing in depressed subjects. Neuropsychopharmacology. 34, 932\u2013943 (2009).","journal-title":"Neuropsychopharmacology"},{"key":"BFsrep43105_CR19","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1017\/S0033291708004443","volume":"39","author":"N Vasic","year":"2009","unstructured":"Vasic, N., Walter, H., Sambataro, F. & Wolf, R. C. Aberrant functional connectivity of dorsolateral prefrontal and cingulate networks in patients with major depression during working memory processing. Psychol Med. 39, 977\u2013987 (2009).","journal-title":"Psychol Med."},{"key":"BFsrep43105_CR20","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.biopsych.2006.09.020","volume":"62","author":"MD Greicius","year":"2007","unstructured":"Greicius, M. D. et al. Resting-state functional connectivity in major depression: Abnormally increased contributions from subgenual cingulate cortex and thalamus. Biol. Psychiatry. 62, 429\u2013437 (2007).","journal-title":"Biol. Psychiatry."},{"key":"BFsrep43105_CR21","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1111\/j.1440-1819.2009.02030.x","volume":"63","author":"R Neufeld","year":"2009","unstructured":"Neufeld, R. & Osuch, E. Resting state default-mode network connectivity in early depression using a seed region-of-interest analysis: decreased connectivity with caudate nucleus. Psychiatry Clin. Neurosci. 63, 754\u2013761 (2009).","journal-title":"Psychiatry Clin. Neurosci."},{"key":"BFsrep43105_CR22","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1111\/j.1469-7610.2012.02552.x","volume":"53","author":"MS Gaffrey","year":"2012","unstructured":"Gaffrey, M. S., Luby, J. L., Botteron, K., Repovs, G. & Barch, D. M. Default mode network connectivity in children with a history of preschool onset depression. J Child Psychol Psychiatry. 53, 964\u2013972 (2012).","journal-title":"J Child Psychol Psychiatry"},{"key":"BFsrep43105_CR23","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.neuroscience.2012.09.039","volume":"227","author":"B Enzi","year":"2012","unstructured":"Enzi, B. et al. Glutamate modulates resting state activity in the perigenual anterior cingulate cortex \u2013 a combined fMRI\u2013MRS study. Neuroscience. 227, 102\u2013109 (2012).","journal-title":"Neuroscience"},{"key":"BFsrep43105_CR24","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.neubiorev.2015.07.014","volume":"56","author":"PC Mulders","year":"2015","unstructured":"Mulders, P. C., van Eijndhoven, P. F., Schene, A. H., Beckmann, C. F. & Tendolkar, I. Resting-state functional connectivity in major depressive disorder: A review. Neurosci Biobehav Rev. 56, 330\u2013344 (2015).","journal-title":"Neurosci Biobehav Rev"},{"key":"BFsrep43105_CR25","doi-asserted-by":"crossref","first-page":"1942","DOI":"10.1073\/pnas.0812686106","volume":"106","author":"R Bluhm","year":"2009","unstructured":"Bluhm, R. et al. The default mode network and self-referential processes in depression. Proc. Natl. Acad. Sci. USA 106, 1942\u20131947 (2009).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFsrep43105_CR26","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.biopsych.2015.02.020","volume":"78","author":"JP Hamilton","year":"2015","unstructured":"Hamilton, J. P., Farmer, M., Fogelman, P. & Gotlib, I. H. Depressive Rumination, the Default-Mode Network, and the Dark Matter of Clinical Neuroscience. Biol. Psychiatry. 78, 224\u2013230 (2015).","journal-title":"Biol. Psychiatry."},{"key":"BFsrep43105_CR27","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1093\/scan\/nsq080","volume":"6","author":"MG Berman","year":"2011","unstructured":"Berman, M. G. et al. Depression, rumination and the default network. Soc Cogn Affect Neurosci. 6, 548\u2013555 (2011).","journal-title":"Soc Cogn Affect Neurosci"},{"key":"BFsrep43105_CR28","doi-asserted-by":"crossref","first-page":"85","DOI":"10.3758\/s13415-010-0014-x","volume":"11","author":"MG Berman","year":"2011","unstructured":"Berman, M. G. et al. Neural and behavioral effects of interference resolution in depression and rumination. Cogn Affective Behav Neurosci. 11, 85\u201396 (2011).","journal-title":"Cogn Affective Behav Neurosci"},{"key":"BFsrep43105_CR29","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/j.biopsych.2011.10.035","volume":"71","author":"XL Zhu","year":"2012","unstructured":"Zhu X. L. et al. Evidence of a dissociation pattern in resting-state default mode network connectivity in first-episode, treatment-naive major depression patients. Biol. Psychiatry. 71, 611\u2013617 (2012).","journal-title":"Biol. Psychiatry."},{"key":"BFsrep43105_CR30","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1038\/mp.2010.46","volume":"16","author":"JP Hamilton","year":"2011","unstructured":"Hamilton, J. P., Chen, G., Thomason, M. E., Schwartz, M. E. & Gotlib, I. H. Investigating neural primacy in Major Depressive Disorder: multivariate Granger causality analysis of resting-state fMRI time-series data. Mol. Psychiatry. 16, 763\u2013772 (2011).","journal-title":"Mol. Psychiatry."},{"key":"BFsrep43105_CR31","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1016\/j.neuron.2010.02.005","volume":"65","author":"JR Andrews-Hanna","year":"2010","unstructured":"Andrews-Hanna, J. R., Reidler, J. S., Sepulcre, J., Poulin, R. & Buckner, R. L. Functional-anatomic fractionation of the brain\u2019s default network. Neuron. 65, 550\u2013562 (2010).","journal-title":"Neuron"},{"key":"BFsrep43105_CR32","doi-asserted-by":"crossref","first-page":"e19","DOI":"10.1016\/j.neurobiolaging.2011.06.024","volume":"33","author":"JS Damoiseaux","year":"2012","unstructured":"Damoiseaux, J. S., Prater, K. E., Miller, B. L. & Greicius, M. D. Functional connectivity tracks clinical deterioration in Alzheimer\u2019s disease. Neurobiol. Aging. 33, 828, e19\u2013e30 (2012).","journal-title":"Neurobiol. Aging."},{"key":"BFsrep43105_CR33","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1192\/bjp.bp.113.137380","volume":"205","author":"JC Beucke","year":"2014","unstructured":"Beucke, J. C. et al. Default mode network subsystem alterations in obsessive-compulsive disorder. Br J Psychiatry. 205, 376\u2013382 (2014).","journal-title":"Br J Psychiatry"},{"key":"BFsrep43105_CR34","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.schres.2015.11.021","volume":"170","author":"Y Du.","year":"2016","unstructured":"Du. Y. et al. Interaction among subsystems within default mode network diminished in schizophrenia patients: A dynamic connectivity approach. Schizophr. Res. 170, 55\u201365 (2016).","journal-title":"Schizophr. Res."},{"key":"BFsrep43105_CR35","doi-asserted-by":"crossref","first-page":"2041","DOI":"10.1017\/S0033291713002596","volume":"44","author":"F Sambataro","year":"2014","unstructured":"Sambataro, F., Wolf, N. D., Pennuto, M., Vasic, N. & Wolf, R. C. Revisiting default mode network function in major depression: Evidence for disrupted subsystem connectivity. Psychol Med. 44, 2041\u20132051 (2014).","journal-title":"Psychol Med."},{"key":"BFsrep43105_CR36","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1196\/annals.1440.011","volume":"1124","author":"RL Buckner","year":"2008","unstructured":"Buckner, R. L., Andrews-Hanna, J. R. & Schacter, D. L. The brain\u2019s default network: Anatomy, function, and relevance to disease. Proc. Natl. Acad. Sci. USA 1124, 1\u201338 (2008).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFsrep43105_CR37","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1176\/jnp.9.3.471","volume":"9","author":"HS Mayberg","year":"1997","unstructured":"Mayberg, H. S. Limbic-cortical dysregulation: a proposed model of depression. J Neuropsychiatry Clin Neurosci. 9, 471\u2013481 (1997).","journal-title":"J Neuropsychiatry Clin Neurosci"},{"key":"BFsrep43105_CR38","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1093\/bmb\/65.1.193","volume":"65","author":"HS Mayberg","year":"2003","unstructured":"Mayberg, H. S. Modulating dysfunctional limbic-cortical circuits in depression: towards development of brain-based algorithms for diagnosis and optimized treatment. Br. Med. Bull. 65, 193\u2013207 (2003).","journal-title":"Br. Med. Bull"},{"key":"BFsrep43105_CR39","doi-asserted-by":"crossref","first-page":"4259","DOI":"10.1073\/pnas.071043098","volume":"98","author":"DA Gusnard","year":"2001","unstructured":"Gusnard, D. A., Akbudak, E., Shulman, G. L. & Raichle, M. E. Medial prefrontal cortex and self-referential mental activity: relation to a default mode of brain function. Proc. Natl. Acad. Sci. USA 98, 4259\u20134264 (2001).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFsrep43105_CR40","doi-asserted-by":"crossref","first-page":"1938","DOI":"10.1176\/appi.ajp.160.11.1938","volume":"160","author":"P Fossati","year":"2003","unstructured":"Fossati, P. et al. In search of the emotional self: an fMRI study using positive and negative emotional words. Am J Psychiatry. 160, 1938\u20131945 (2003).","journal-title":"Am J Psychiatry"},{"key":"BFsrep43105_CR41","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.tics.2004.01.004","volume":"8","author":"G Northoff","year":"2004","unstructured":"Northoff, G. & Bermpohl, F. Cortical midline structures and the self. Trends Cogn. Sci. 8, 102\u2013107 (2004).","journal-title":"Trends Cogn. Sci."},{"key":"BFsrep43105_CR42","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.tics.2010.11.004","volume":"15","author":"A Etkin","year":"2011","unstructured":"Etkin, A., Egner, T. & Kalisch, R. Emotional processing in anterior cingulate and medial prefrontal cortex. Trends Cogn. Sci. 15, 85\u201393 (2011).","journal-title":"Trends Cogn. Sci."},{"key":"BFsrep43105_CR43","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1001\/archpsyc.64.2.193","volume":"64","author":"G Hasler","year":"2007","unstructured":"Hasler, G. et al. Reduced prefrontal glutamate\/glutamine and gamma-aminobu- tyric acid levels in major depression determined using proton magnetic resonance spectroscopy. Arch Gen Psychiatry. 64, 193\u2013200 (2007).","journal-title":"Arch Gen Psychiatry"},{"key":"BFsrep43105_CR44","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1017\/S104161020999007X","volume":"21","author":"AA Khundakar","year":"2009","unstructured":"Khundakar, A. A. & Thomas, A. J. Morphometric changes in early- and late-life major depressive disorder: evidence from postmortem studies. Int Psychogeriatr. 21, 844\u2013854 (2009).","journal-title":"Int Psychogeriatr."},{"key":"BFsrep43105_CR45","doi-asserted-by":"crossref","first-page":"2927","DOI":"10.1017\/S0033291714000518","volume":"44","author":"YJ Zhao","year":"2014","unstructured":"Zhao, Y. J. et al. Brain grey matter abnormalities in medication-free patients with major depressive disorder: a meta-analysis. Psychol Med. 44, 2927\u20132937 (2014).","journal-title":"Psychol Med."},{"key":"BFsrep43105_CR46","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.neuroimage.2014.01.032","volume":"91","author":"JR Andrews-Hanna","year":"2014","unstructured":"Andrews-Hanna, J. R., Saxe, R. & Yarkoni, T. Contributions of episodic retrieval and mentalizing to autobiographical thought: evidence from functional neuroimaging, resting-state connectivity, and fMRI meta-analyses. NeuroImage. 91, 324\u2013335 (2014).","journal-title":"NeuroImage"},{"key":"BFsrep43105_CR47","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1002\/(SICI)1096-9861(19990802)410:3<343::AID-CNE1>3.0.CO;2-1","volume":"410","author":"H Barbas","year":"1999","unstructured":"Barbas, H., Ghashghaei, H., Dombrowski, S. M. & Rempel-Clower, N. L. Medial prefrontal cortices are unified by common connections with superior temporal cortices and distinguished by input from memory-related areas in the rhesus monkey. J Comp Neurol. 410, 343\u2013367 (1999).","journal-title":"J Comp Neurol"},{"key":"BFsrep43105_CR48","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1196\/annals.1401.008","volume":"1121","author":"JL Price","year":"2007","unstructured":"Price, J. L. Definition of the orbital cortex in relation to specific connections with limbic and visceral structures. Ann N Y Acad of Sci. 1121, 54\u201371 (2007).","journal-title":"Ann N Y Acad of Sci"},{"key":"BFsrep43105_CR49","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.jad.2015.04.052","volume":"183","author":"Y Chen","year":"2015","unstructured":"Chen, Y., Wang, C., Zhu, X., Tan, Y. & Zhong, Y. Aberrant connectivity within the default mode network in first-episode, treatment-na\u00efve major depressive disorder. J Affect Disord. 183, 49\u201356 (2015).","journal-title":"J Affect Disord"},{"key":"BFsrep43105_CR50","doi-asserted-by":"crossref","first-page":"2053","DOI":"10.1017\/S0033291713002742","volume":"44","author":"Tol Van","year":"2013","unstructured":"Van, T.o.l. et al. Local cortical thinning links to resting-state disconnectivity in major depressive disorder. Psychol. Med. 44, 2053\u20132065 (2013).","journal-title":"Psychol. Med."},{"key":"BFsrep43105_CR51","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.jad.2011.12.002","volume":"139","author":"G Alexopoulos","year":"2012","unstructured":"Alexopoulos, G. et al. Functional connectivity in cognitive control network and the default mode network in late-life depression. J. Affect. Disord. 139, 56\u201365 (2012).","journal-title":"J. Affect. Disord."},{"key":"BFsrep43105_CR52","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.pscychresns.2011.04.003","volume":"194","author":"M Wu","year":"2011","unstructured":"Wu, M. et al. Default-mode network connectivity and white matter burden in late-life depression. Psychiatry Res. 194, 39\u201346 (2011).","journal-title":"Psychiatry Res."},{"key":"BFsrep43105_CR53","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.pscychresns.2013.08.007","volume":"214","author":"C Andreescu","year":"2013","unstructured":"Andreescu, C. et al. Resting state functional connectivity and treatment response in late-life depression. Psychiatry Res. 214, 313\u2013321 (2013).","journal-title":"Psychiatry Res."},{"key":"BFsrep43105_CR54","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.neuroimage.2012.11.008","volume":"69","author":"YH Du","year":"2013","unstructured":"Du, Y. H. & Fan, Y. Group information guided ICA for fMRI data analysis. NeuroImage. 69, 157\u2013197 (2013).","journal-title":"NeuroImage"},{"key":"BFsrep43105_CR55","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1001\/jamapsychiatry.2015.0071","volume":"72","author":"RH Kaiser","year":"2015","unstructured":"Kaiser, R. H., Andrews-Hanna, J. R., Wager, T. D. & Pizzagalli, D. A. Large-scale network dysfunction in major depressive disorder: a meta-analysis of resting-state functional connectivity. JAMA Psychiatry. 72, 603\u2013611 (2015).","journal-title":"JAMA Psychiatry"},{"key":"BFsrep43105_CR56","doi-asserted-by":"crossref","first-page":"1822","DOI":"10.1038\/npp.2015.352","volume":"41","author":"RH Kaiser","year":"2016","unstructured":"Kaiser, R. H. et al. Dynamic Resting-State Functional Connectivity in Major Depression. Neuropsychopharmacology. 41, 1822\u20131830 (2016).","journal-title":"Neuropsychopharmacology"},{"key":"BFsrep43105_CR57","unstructured":"First, M. B., Spitzer, R. L., Gibbon, M. & Williams, J. B. Structured Clinical Interview for DSM-IV Axis I Disorders: Patient Edition, SCID-I\/P (New York, 1998)."},{"key":"BFsrep43105_CR58","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1177\/014662167700100306","volume":"1","author":"LS Radloff","year":"1977","unstructured":"Radloff, L. S. The CES-D scale: A self-report depression scale for research in the general population. Appl Psychol Meas. 1, 385\u2013401 (1977).","journal-title":"Appl Psychol Meas"},{"key":"BFsrep43105_CR59","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1002\/jclp.21978","volume":"69","author":"M Wang","year":"2013","unstructured":"Wang, M. et al. Factor structure of the CES-D and measurement invariance across gender in Mainland Chinese adolescents. J. Clin. Psychol. 69, 966\u2013979 (2013).","journal-title":"J. Clin. Psychol."},{"key":"BFsrep43105_CR60","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1037\/0022-006X.68.6.976","volume":"68","author":"JK Connor-Smith","year":"2000","unstructured":"Connor-Smith, J. K., Compas, B. E., Wadsworth, M. E., Thomsen, A. H. & Saltzman, H. Responses to stress in adolescence: measurement of coping and involuntary stress responses. J Consult Clin Psychol. 68, 976\u2013992 (2000).","journal-title":"J Consult Clin Psychol"},{"key":"BFsrep43105_CR61","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1080\/00223891.2010.482015","volume":"92","author":"S Yao","year":"2010","unstructured":"Yao, S. et al. Coping and involuntary responses to stress in Chinese university students: psychometric properties of the responses to stress questionnaire. J Pers Assess. 92, 356\u2013361 (2010).","journal-title":"J Pers Assess"},{"key":"BFsrep43105_CR62","first-page":"13","volume":"4","author":"Y Chao-Gan","year":"2010","unstructured":"Chao-Gan, Y. & Yu-Feng, Z. DPARSF. A MATLAB Toolbox for \u201cPipeline\u201d Data Analysis of Resting-State fMRI. Front Syst Neurosci. 4, 13 (2010).","journal-title":"Front Syst Neurosci"},{"key":"BFsrep43105_CR63","doi-asserted-by":"crossref","first-page":"e25031","DOI":"10.1371\/journal.pone.0025031","volume":"6","author":"XW Song","year":"2011","unstructured":"Song, X. W. et al. REST: a toolkit for resting-state functional magnetic resonance imaging data processing. PloS One. 6, e25031 (2011).","journal-title":"PloS One."},{"key":"BFsrep43105_CR64","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1006\/nimg.2002.1132","volume":"17","author":"M Jenkinson","year":"2002","unstructured":"Jenkinson, M., Bannister, P., Brady, M. & Smith, S. Improved optimization for the robust and accurate linear registration and motion correction of brain images. Neuroimage. 17, 825\u2013841 (2002).","journal-title":"Neuroimage"},{"key":"BFsrep43105_CR65","doi-asserted-by":"crossref","first-page":"2142","DOI":"10.1016\/j.neuroimage.2011.10.018","volume":"59","author":"JD Power","year":"2012","unstructured":"Power, J. D., Barnes, K. A., Snyder, A. Z., Schlaggar, B. L. & Petersen, S. E. Spurious but systematic correlations in functional connectivity MRI networks arise from subject motion. NeuroImage. 59, 2142\u20132154 (2012).","journal-title":"NeuroImage"},{"key":"BFsrep43105_CR66","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.neuroimage.2013.08.048","volume":"84","author":"JD Power","year":"2014","unstructured":"Power, J. D. et al. Methods to detect, characterize, and remove motion artifact in resting state fMRI. NeuroImage. 84, 320\u2013341 (2014).","journal-title":"NeuroImage"},{"key":"BFsrep43105_CR67","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.neuroimage.2013.03.004","volume":"76","author":"CG Yan","year":"2013","unstructured":"Yan, C. G. et al. A comprehensive assessment of regional variation in the impact of head micromovements on functional connectomics. NeuroImage. 76, 183\u2013201 (2013).","journal-title":"NeuroImage"},{"key":"BFsrep43105_CR68","doi-asserted-by":"crossref","first-page":"4028","DOI":"10.1073\/pnas.0800376105","volume":"105","author":"DA Fair","year":"2008","unstructured":"Fair, D. A. et al. The maturing architecture of the brain\u2019s default network. Proc. Natl. Acad. Sci. USA 105, 4028\u20134032 (2008).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFsrep43105_CR69","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11682-015-9362-z","volume":"10","author":"Y Xiao","year":"2016","unstructured":"Xiao, Y., Zhai, H., Friederici, A. D. & Jia, F. The development of the intrinsic functional connectivity of default network subsystems from age 3 to 5. Brain Imaging Behav. 10, 1\u201310 (2016).","journal-title":"Brain Imaging Behav"},{"key":"BFsrep43105_CR70","doi-asserted-by":"crossref","first-page":"e68910","DOI":"10.1371\/journal.pone.0068910","volume":"8","author":"M Xia","year":"2013","unstructured":"Xia, M., Wang, J. & He, Y. BrainNet viewer: a network visualization tool for human brain connectomics. PLoS One. 8, e68910 (2013).","journal-title":"PLoS One."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/srep43105","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/srep43105.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/srep43105.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,23]],"date-time":"2022-12-23T14:52:37Z","timestamp":1671807157000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/srep43105"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2,22]]},"references-count":70,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2017,3,24]]}},"alternative-id":["BFsrep43105"],"URL":"https:\/\/doi.org\/10.1038\/srep43105","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,2,22]]},"assertion":[{"value":"19 August 2016","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 January 2017","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 February 2017","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing financial interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"43105"}}