{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T03:02:31Z","timestamp":1773198151486,"version":"3.50.1"},"reference-count":51,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2017,3,3]],"date-time":"2017-03-03T00:00:00Z","timestamp":1488499200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2017,3,3]],"date-time":"2017-03-03T00:00:00Z","timestamp":1488499200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Schwann cells (SCs) can promote the regeneration of injured peripheral nerves while the clinical application is limited by donor site complications and the inability to generate an ample amount of cells. In this study, we have isolated human eyelid adipose-derived Schwann cells (hE-SCs) from human eyelid adipose tissue and identified the cell phenotype and function. Using immunofluorescence and H &amp; E staining, we detected subtle nerve fibers and SCs in human eyelid adipose tissue. Immunofluorescence staining indicated that hE-SCs expressed glial markers, such as S100, p75NTR GFAP, Sox10 and Krox20. To explore whether hE-SCs promote the regeneration of injured peripheral nerves<jats:italic>in vivo,<\/jats:italic>a Balb\/c-nu mice model was used in the study, and mice were randomly assigned to five groups: Matrigel; hE-SCs\/P0; hE-SCs\/P2; hE-FLCs\/P2; and Autograft. After 12 weeks, functional and histological assessments of the regenerated nerves showed that sciatic nerve defect was more effectively repaired in the hE-SCs\/P2 group which achieved 66.1\u2009\u00b1\u20096.5% purity, than the other three groups and recovered to similar level to the Autograft group. These results indicated that hE-SCs can promote the regeneration of injured peripheral nerve and the abundant, easily accessible supply of adipose tissue might be a promising source of SCs for peripheral nerve repair.<\/jats:p>","DOI":"10.1038\/srep43248","type":"journal-article","created":{"date-parts":[[2017,3,3]],"date-time":"2017-03-03T13:15:45Z","timestamp":1488546945000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Human eyelid adipose tissue-derived Schwann cells promote regeneration of a transected sciatic nerve"],"prefix":"10.1038","volume":"7","author":[{"given":"Gangyang","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lingling","family":"Cao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingqi","family":"Hua","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhengdong","family":"Cai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lulu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuqing","family":"Jin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lina","family":"Niu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hua","family":"Shen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zunli","family":"Shen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2017,3,3]]},"reference":[{"key":"BFsrep43248_CR1","first-page":"303","volume":"11","author":"M Wiberg","year":"2003","unstructured":"Wiberg, M. & Terenghi, G. Will it be possible to produce peripheral nerves? Surg Technol Int 11, 303\u2013310 (2003).","journal-title":"Surg Technol Int"},{"key":"BFsrep43248_CR2","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1097\/00005373-199807000-00025","volume":"45","author":"J Noble","year":"1998","unstructured":"Noble, J., Munro, C. A., Prasad, V. S. & Midha, R. Analysis of upper and lower extremity peripheral nerve injuries in a population of patients with multiple injuries. J Trauma 45, 116\u2013122 (1998).","journal-title":"J Trauma"},{"key":"BFsrep43248_CR3","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.1016\/j.bjps.2009.12.010","volume":"63","author":"A Pabari","year":"2010","unstructured":"Pabari, A., Yang, S. Y., Seifalian, A. M. & Mosahebi, A. Modern surgical management of peripheral nerve gap. J Plast Reconstr Aesthet Surg 63, 1941\u20131948 (2010).","journal-title":"J Plast Reconstr Aesthet Surg"},{"key":"BFsrep43248_CR4","doi-asserted-by":"crossref","first-page":"7086","DOI":"10.1016\/j.biomaterials.2013.05.080","volume":"34","author":"S Tang","year":"2013","unstructured":"Tang, S. et al. The effects of gradients of nerve growth factor immobilized PCLA scaffolds on neurite outgrowth in vitro and peripheral nerve regeneration in rats. Biomaterials 34, 7086\u20137096 (2013).","journal-title":"Biomaterials"},{"key":"BFsrep43248_CR5","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1053\/jhsu.2000.4165","volume":"25","author":"G Lundborg","year":"2000","unstructured":"Lundborg, G. A 25-year perspective of peripheral nerve surgery: evolving neuroscientific concepts and clinical significance. J Hand Surg Am 25, 391\u2013414 (2000).","journal-title":"J Hand Surg Am"},{"key":"BFsrep43248_CR6","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1586\/14737175.2014.887444","volume":"14","author":"V Carriel","year":"2014","unstructured":"Carriel, V., Alaminos, M., Garzon, I., Campos, A. & Cornelissen, M. Tissue engineering of the peripheral nervous system. Expert Rev Neurother 14, 301\u2013318 (2014).","journal-title":"Expert Rev Neurother"},{"key":"BFsrep43248_CR7","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.hcl.2013.04.003","volume":"29","author":"MY Lin","year":"2013","unstructured":"Lin, M. Y., Manzano, G. & Gupta, R. Nerve allografts and conduits in peripheral nerve repair. Hand Clin 29, 331\u2013348 (2013).","journal-title":"Hand Clin"},{"key":"BFsrep43248_CR8","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.expneurol.2009.09.009","volume":"223","author":"X Jiang","year":"2010","unstructured":"Jiang, X., Lim, S. H., Mao, H. Q. & Chew, S. Y. Current applications and future perspectives of artificial nerve conduits. Exp Neurol 223, 86\u2013101 (2010).","journal-title":"Exp Neurol"},{"key":"BFsrep43248_CR9","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/0959-4388(93)90157-T","volume":"3","author":"RP Bunge","year":"1993","unstructured":"Bunge, R. P. Expanding roles for the Schwann cell: ensheathment, myelination, trophism and regeneration. Curr Opin Neurobiol 3, 805\u2013809 (1993).","journal-title":"Curr Opin Neurobiol"},{"key":"BFsrep43248_CR10","doi-asserted-by":"crossref","first-page":"1995","DOI":"10.1016\/j.biocel.2006.05.007","volume":"38","author":"K Bhatheja","year":"2006","unstructured":"Bhatheja, K. & Field, J. Schwann cells: origins and role in axonal maintenance and regeneration. Int J Biochem Cell Biol 38, 1995\u20131999 (2006).","journal-title":"Int J Biochem Cell Biol"},{"key":"BFsrep43248_CR11","first-page":"413091","volume":"2012","author":"MC Rodrigues","year":"2012","unstructured":"Rodrigues, M. C., Rodrigues, A. J., Glover, L. E., Voltarelli, J. & Borlongan, C. V. Peripheral nerve repair with cultured schwann cells: getting closer to the clinics. ScientificWorldJournal 2012, 413091 (2012).","journal-title":"ScientificWorldJournal"},{"key":"BFsrep43248_CR12","doi-asserted-by":"crossref","first-page":"29121","DOI":"10.1038\/srep29121","volume":"6","author":"S Yi","year":"2016","unstructured":"Yi, S. et al. Regulation of Schwann cell proliferation and migration by miR-1 targeting brain-derived neurotrophic factor after peripheral nerve injury. Sci Rep 6, 29121 (2016).","journal-title":"Sci Rep"},{"key":"BFsrep43248_CR13","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1002\/micr.20192","volume":"26","author":"Q Li","year":"2006","unstructured":"Li, Q., Ping, P., Jiang, H. & Liu, K. Nerve conduit filled with GDNF gene-modified Schwann cells enhances regeneration of the peripheral nerve. Microsurg 26, 116\u2013121 (2006).","journal-title":"Microsurg"},{"key":"BFsrep43248_CR14","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/j.expneurol.2010.01.022","volume":"223","author":"S Wakao","year":"2010","unstructured":"Wakao, S. et al. Long-term observation of auto-cell transplantation in non-human primate reveals safety and efficiency of bone marrow stromal cell-derived Schwann cells in peripheral nerve regeneration. Exp Neurol 223, 537\u2013547 (2010).","journal-title":"Exp Neurol"},{"key":"BFsrep43248_CR15","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.3892\/mmr.2014.2840","volume":"11","author":"YZ Xiao","year":"2015","unstructured":"Xiao, Y. Z. & Wang, S. Differentiation of Schwannlike cells from human umbilical cord blood mesenchymal stem cells in vitro . Mol Med Rep 11, 1146\u20131152 (2015).","journal-title":"Mol Med Rep"},{"key":"BFsrep43248_CR16","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1002\/1097-4547(20000815)61:4<364::AID-JNR2>3.0.CO;2-C","volume":"61","author":"D Woodbury","year":"2000","unstructured":"Woodbury, D., Schwarz, E. J., Prockop, D. J. & Black, I. B. Adult rat and human bone marrow stromal cells differentiate into neurons. J Neurosci Res 61, 364\u2013370 (2000).","journal-title":"J Neurosci Res"},{"key":"BFsrep43248_CR17","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.expneurol.2004.01.027","volume":"187","author":"KM Safford","year":"2004","unstructured":"Safford, K. M., Safford, S. D., Gimble, J. M., Shetty, A. K. & Rice, H. E. Characterization of neuronal\/glial differentiation of murine adipose-derived adult stromal cells. Exp Neurol 187, 319\u2013328 (2004).","journal-title":"Exp Neurol"},{"key":"BFsrep43248_CR18","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1002\/jcb.22534","volume":"110","author":"Y Amoh","year":"2010","unstructured":"Amoh, Y. et al. Direct transplantation of uncultured hair-follicle pluripotent stem (hfPS) cells promotes the recovery of peripheral nerve injury. J Cell Biochem 110, 272\u2013277 (2010).","journal-title":"J Cell Biochem"},{"key":"BFsrep43248_CR19","doi-asserted-by":"crossref","first-page":"162439","DOI":"10.1155\/2015\/162439","volume":"2015","author":"C Siciliano","year":"2015","unstructured":"Siciliano, C. et al. The potential of GMP-compliant platelet lysate to induce a permissive state for cardiovascular transdifferentiation in human mediastinal adipose tissue-derived mesenchymal stem cells. Biomed Res Int 2015, 162439 (2015).","journal-title":"Biomed Res Int"},{"key":"BFsrep43248_CR20","doi-asserted-by":"crossref","first-page":"3939","DOI":"10.1242\/dev.080549","volume":"140","author":"DC Berry","year":"2013","unstructured":"Berry, D. C., Stenesen, D., Zeve, D. & Graff, J. M. The developmental origins of adipose tissue. Development 140, 3939\u20133949 (2013).","journal-title":"Development"},{"key":"BFsrep43248_CR21","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1038\/ncb2696","volume":"15","author":"R Berry","year":"2013","unstructured":"Berry, R. & Rodeheffer, M. S. Characterization of the adipocyte cellular lineage in vivo . Nat Cell Biol 15, 302\u2013308 (2013).","journal-title":"Nat Cell Biol"},{"key":"BFsrep43248_CR22","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1056\/NEJMoa0810780","volume":"360","author":"AM Cypess","year":"2009","unstructured":"Cypess, A. M. et al. Identification and importance of brown adipose tissue in adult humans. N Engl J Med 360, 1509\u20131517 (2009).","journal-title":"N Engl J Med"},{"key":"BFsrep43248_CR23","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.cell.2007.10.004","volume":"131","author":"S Gesta","year":"2007","unstructured":"Gesta, S., Tseng, Y. H. & Kahn, C. R. Developmental origin of fat: tracking obesity to its source. Cell 131, 242\u2013256 (2007).","journal-title":"Cell"},{"key":"BFsrep43248_CR24","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1016\/j.metabol.2003.11.012","volume":"53","author":"V van Harmelen","year":"2004","unstructured":"van Harmelen, V., R\u00f6hrig, K. & Hauner, H. Comparison of proliferation and differentiation capacity of human adipocyte precursor cells from the omental and subcutaneous adipose tissue depot of obese subjects. Metabolism 53, 632\u2013637 (2004).","journal-title":"Metabolism"},{"key":"BFsrep43248_CR25","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1111\/cpr.12027","volume":"46","author":"SH Kim","year":"2013","unstructured":"Kim, S. H. et al. Character comparison of abdomen-derived and eyelid-derived mesenchymal stem cells. Cell Proliferat 46, 291\u2013299 (2013).","journal-title":"Cell Proliferat"},{"key":"BFsrep43248_CR26","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1007\/s00441-007-0555-7","volume":"332","author":"WJFM Jurgens","year":"2008","unstructured":"Jurgens, W. J. F. M. et al. Effect of tissue-harvesting site on yield of stem cells derived from adipose tissue: implications for cell-based therapies. Cell Tissue Res 332, 415\u2013426 (2008).","journal-title":"Cell Tissue Res"},{"key":"BFsrep43248_CR27","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1111\/jcmm.12191","volume":"18","author":"J Zhou","year":"2014","unstructured":"Zhou, J. et al. 17\u03b2-Estradiol Protects Human Eyelid-Derived Adipose Stem Cells against Cytotoxicity and Increases Transplanted Cell Survival in Spinal Cord injury. Journal of Cellular and Molecular Medicine 18, 326\u2013343 (2014).","journal-title":"Journal of Cellular and Molecular Medicine"},{"key":"BFsrep43248_CR28","doi-asserted-by":"crossref","first-page":"e105","DOI":"10.1016\/j.bjps.2013.10.034","volume":"67","author":"A Amit","year":"2014","unstructured":"Amit, A. & Tuabin, R. A simple plunger technique for negative pressure during fat harvesting. J Plast Reconstr Aesthet Surg 67, e105\u2013e106 (2014).","journal-title":"J Plast Reconstr Aesthet Surg"},{"key":"BFsrep43248_CR29","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1007\/s00266-014-0371-x","volume":"38","author":"NF Hubner","year":"2014","unstructured":"Hubner, N. F., Horch, R. E., Polykandriotis, E., Rau, T. T. & Dragu, A. A histopathologic and immunohistochemical study on liquification of human adipose tissue ex vivo . Aesthetic Plast Surg 38, 976\u2013984 (2014).","journal-title":"Aesthetic Plast Surg"},{"key":"BFsrep43248_CR30","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1002\/jnr.20166","volume":"77","author":"C Mauritz","year":"2004","unstructured":"Mauritz, C., Grothe, C. & Haastert, K. Comparative study of cell culture and purification methods to obtain highly enriched cultures of proliferating adult rat Schwann cells. J Neurosci Res 77, 453\u2013461 (2004).","journal-title":"J Neurosci Res"},{"key":"BFsrep43248_CR31","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/0006-8993(79)90851-5","volume":"174","author":"MC Raff","year":"1979","unstructured":"Raff, M. C. et al. Cell-type-specific markers for distinguishing and studying neurons and the major classes of glial cells in culture. Brain Res 174, 283\u2013308 (1979).","journal-title":"Brain Res"},{"key":"BFsrep43248_CR32","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S0165-0270(02)00382-5","volume":"124","author":"M Vroemen","year":"2003","unstructured":"Vroemen, M. & Weidner, N. Purification of Schwann cells by selection of p75 low affinity nerve growth factor receptor expressing cells from adult peripheral nerve. J Neurosci Methods 124, 135\u2013143 (2003).","journal-title":"J Neurosci Methods"},{"key":"BFsrep43248_CR33","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.expneurol.2016.02.006","volume":"278","author":"R Kumar","year":"2016","unstructured":"Kumar, R. et al. Adult skin-derived precursor Schwann cells exhibit superior myelination and regeneration supportive properties compared to chronically denervated nerve-derived Schwann cells. Exp Neurol 278, 127\u2013142 (2016).","journal-title":"Exp Neurol"},{"key":"BFsrep43248_CR34","doi-asserted-by":"crossref","unstructured":"Levi, A. D. et al. The use of autologous Schwann cells to supplement sciatic nerve repair with a large gap - First in human experience. Cell Transplant (2015).","DOI":"10.3727\/096368915X690198"},{"key":"BFsrep43248_CR35","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/s12929-015-0144-0","volume":"22","author":"M Kabiri","year":"2015","unstructured":"Kabiri, M. et al. Neuroregenerative effects of olfactory ensheathing cells transplanted in a multi-layered conductive nanofibrous conduit in peripheral nerve repair in rats. J Biomed Sci 22, 35 (2015).","journal-title":"J Biomed Sci"},{"key":"BFsrep43248_CR36","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1002\/micr.22480","volume":"36","author":"FM Walocko","year":"2016","unstructured":"Walocko, F. M., Khouri, R. J., Urbanchek, M. G., Levi, B. & Cederna, P. S. The potential roles for adipose tissue in peripheral nerve regeneration. Microsurg 36, 81\u201388 (2016).","journal-title":"Microsurg"},{"key":"BFsrep43248_CR37","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.neulet.2012.02.066","volume":"514","author":"Y Wang","year":"2012","unstructured":"Wang, Y. et al. Recellularized nerve allografts with differentiated mesenchymal stem cells promote peripheral nerve regeneration. Neurosci Lett 514, 96\u2013101 (2012).","journal-title":"Neurosci Lett"},{"key":"BFsrep43248_CR38","doi-asserted-by":"crossref","first-page":"389520","DOI":"10.1155\/2015\/389520","volume":"2015","author":"V Buzoianu-Anguiano","year":"2015","unstructured":"Buzoianu-Anguiano, V. et al. The Morphofunctional Effect of the Transplantation of Bone Marrow Stromal Cells and Predegenerated Peripheral Nerve in Chronic Paraplegic Rat Model via Spinal Cord Transection. Neural Plast 2015, 389520 (2015).","journal-title":"Neural Plast"},{"key":"BFsrep43248_CR39","doi-asserted-by":"crossref","first-page":"806","DOI":"10.3171\/jns.2004.101.5.0806","volume":"101","author":"T Mimura","year":"2004","unstructured":"Mimura, T., Dezawa, M., Kanno, H., Sawada, H. & Yamamoto, I. Peripheral nerve regeneration by transplantation of bone marrow stromal cell-derived Schwann cells in adult rats. J Neurosurg 101, 806\u2013812 (2004).","journal-title":"J Neurosurg"},{"key":"BFsrep43248_CR40","doi-asserted-by":"crossref","first-page":"53","DOI":"10.4103\/1673-5374.175042","volume":"11","author":"JA Stratton","year":"2016","unstructured":"Stratton, J. A. & Shah, P. T. Macrophage polarization in nerve injury: do Schwann cells play a role? Neural Regen Res 11, 53\u201357 (2016).","journal-title":"Neural Regen Res"},{"key":"BFsrep43248_CR41","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.brainres.2015.10.040","volume":"1638","author":"HC Lehmann","year":"2016","unstructured":"Lehmann, H. C. & Hoke, A. Use of engineered Schwann cells in peripheral neuropathy: Hopes and hazards. Brain Res 1638, 97\u2013104 (2016).","journal-title":"Brain Res"},{"key":"BFsrep43248_CR42","doi-asserted-by":"crossref","first-page":"776","DOI":"10.4103\/1008-682X.154306","volume":"17","author":"L Wang","year":"2015","unstructured":"Wang, L., Sanford, M. T., Xin, Z., Lin, G. & Lue, T. F. Role of Schwann cells in the regeneration of penile and peripheral nerves. Asian J Androl 17, 776\u2013782 (2015).","journal-title":"Asian J Androl"},{"key":"BFsrep43248_CR43","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1097\/01.prs.0000182570.62814.e3","volume":"116","author":"LE Kokai","year":"2005","unstructured":"Kokai, L. E., Rubin, J. P. & Marra, K. G. The Potential of Adipose-Derived Adult Stem Cells as a Source of Neuronal Progenitor Cells. Plast Reconstr Surg 116, 1453\u20131460 (2005).","journal-title":"Plast Reconstr Surg"},{"key":"BFsrep43248_CR44","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.jneumeth.2008.01.003","volume":"170","author":"YQ Jin","year":"2008","unstructured":"Jin, Y. Q., Liu, W., Hong, T. H. & Cao, Y. Efficient Schwann cell purification by differential cell detachment using multiplex collagenase treatment. J Neurosci Methods 170, 140\u2013148 (2008).","journal-title":"J Neurosci Methods"},{"key":"BFsrep43248_CR45","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.ejcb.2005.09.021","volume":"85","author":"G Keilhoff","year":"2006","unstructured":"Keilhoff, G., Goihl, A., Langnase, K., Fansa, H. & Wolf, G. Transdifferentiation of mesenchymal stem cells into Schwann cell-like myelinating cells. Eur J Cell Biol 85, 11\u201324 (2006).","journal-title":"Eur J Cell Biol"},{"key":"BFsrep43248_CR46","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.neuroscience.2011.02.052","volume":"181","author":"PG di Summa","year":"2011","unstructured":"di Summa, P. G. et al. Long-term in vivo regeneration of peripheral nerves through bioengineered nerve grafts. Neuroscience 181, 278\u2013291 (2011).","journal-title":"Neuroscience"},{"key":"BFsrep43248_CR47","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1002\/mus.21895","volume":"43","author":"R Mohammadi","year":"2011","unstructured":"Mohammadi, R., Azizi, S., Delirezh, N., Hobbenaghi, R. & Amini, K. Comparison of beneficial effects of undifferentiated cultured bone marrow stromal cells and omental adipose-derived nucleated cell fractions on sciatic nerve regeneration. Muscle Nerve 43, 157\u2013163 (2011).","journal-title":"Muscle Nerve"},{"key":"BFsrep43248_CR48","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1002\/jbm.a.33227","volume":"100","author":"CC Shen","year":"2012","unstructured":"Shen, C. C., Yang, Y. C. & Liu, B. S. Peripheral nerve repair of transplanted undifferentiated adipose tissue-derived stem cells in a biodegradable reinforced nerve conduit. J Biomed Mater Res A 100, 48\u201363 (2012).","journal-title":"J Biomed Mater Res A"},{"key":"BFsrep43248_CR49","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/B978-0-12-410499-0.00008-3","volume":"108","author":"S Raimondo","year":"2013","unstructured":"Raimondo, S. et al. Ghrelin: a novel neuromuscular recovery promoting factor? Int Rev Neurobiol 108, 207\u2013221 (2013).","journal-title":"Int Rev Neurobiol"},{"key":"BFsrep43248_CR50","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1002\/(SICI)1098-1136(199608)17:4<327::AID-GLIA7>3.0.CO;2-W","volume":"17","author":"GT Casella","year":"1996","unstructured":"Casella, G. T., Bunge, R. P. & Wood, P. M. Improved method for harvesting human Schwann cells from mature peripheral nerve and expansion in vitro . Glia 17, 327\u2013338 (1996).","journal-title":"Glia"},{"key":"BFsrep43248_CR51","doi-asserted-by":"crossref","first-page":"e2421","DOI":"10.1038\/cddis.2016.305","volume":"7","author":"T Zhang","year":"2016","unstructured":"Zhang, T. et al. Natural product pectolinarigenin inhibits osteosarcoma growth and metastasis via SHP-1-mediated STAT3 signaling inhibition. Cell Death and Disease 7, e2421 (2016).","journal-title":"Cell Death and Disease"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/srep43248.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/srep43248","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/srep43248.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,22]],"date-time":"2024-06-22T20:12:49Z","timestamp":1719087169000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/srep43248"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3,3]]},"references-count":51,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2017,4,10]]}},"alternative-id":["BFsrep43248"],"URL":"https:\/\/doi.org\/10.1038\/srep43248","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3,3]]},"assertion":[{"value":"5 September 2016","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 January 2017","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 March 2017","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing financial interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"43248"}}