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The PFASs composition profiles of human serum samples nearly make no difference at different locations. A significant increase was observed for \u2211\n                    <jats:sub>8<\/jats:sub>\n                    PFASs, PFOS, and PFHxS concentrations with age (p\u2009&lt;\u20090.01). Gender-related differences were found; PFOS, PFHxS, PFBS, and PFOA levels were higher in males (p\u2009&lt;\u20090.05), and the mean concentration of \u2211\n                    <jats:sub>8<\/jats:sub>\n                    PFASs was 1.5 times greater in males (6.02\u2009ng\/mL) than in females (4.15\u2009ng\/mL). PFOS and \u2211\n                    <jats:sub>8<\/jats:sub>\n                    PFASs were significantly negatively correlated with FT3 and FT4 and positively correlated with TSH while PFPeA and PFHxA were significantly positively correlated with TGAb and TMAb in all the samples. The opposite associations between FT3, TSH and PFOS, PFOA and PFHxS levels in hypothyroidism and hyperthyroidism group indicate that the PFOS, PFOA and PFHxS enhance the negative feedback mechanisms of the thyroid gland.\n                  <\/jats:p>","DOI":"10.1038\/srep43380","type":"journal-article","created":{"date-parts":[[2017,2,27]],"date-time":"2017-02-27T06:06:23Z","timestamp":1488175583000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":56,"title":["Perfluorinated alkyl substances in serum of the southern Chinese general population and potential impact on thyroid hormones"],"prefix":"10.1038","volume":"7","author":[{"given":"Yangjie","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yating","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyong","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,2,27]]},"reference":[{"key":"BFsrep43380_CR1","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1016\/j.chemosphere.2004.11.078","volume":"58","author":"H-J Lehmler","year":"2005","unstructured":"Lehmler, H.-J. 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