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Some evidence supports that hippocampus might involve the neural storage of the \u201cinternal model\u201d. This study established an \u201cinternal model\u201d acquisition-retention behavioral model using a repeated habituation rotation training protocol. We tried to identify the hippocampal subregion involved in \u201cinternal model\u201d retention using chemical lesion methods. Hippocampal kinases (CaMK, CaMKIV, CREB and ERK1\/2) phosphorylation in the target subregion was assayed and the effects of kinase inhibitors (KN93 or U0126) on \u201cinternal model\u201d retention were investigated. The activities of potential kinases (CaMKII and CREB) were also examined in otoliths deficit<jats:italic>het\/het<\/jats:italic>mice. In habituated rats, CA1 lesion reproduced MS-related behavioral responses on \u201cinternal model\u201d retention day. Habituation training increased CaMKII and CREB activity but had no effect on CaMKIV and ERK1\/2 activity in the CA1, while inhibition of CaMKII but not ERK1\/2 impaired \u201cinternal model\u201d retention. In<jats:italic>het\/het<\/jats:italic>mice, CaMKII and CREB were not activated in the CA1 on the retention day. These results suggested that CaMKII\/CREB pathway might potentially contribute to the storage of the \u201cinternal model\u201d in the hippocampal CA1 after motion sickness induced by vestibular stimulation.<\/jats:p>","DOI":"10.1038\/srep43385","type":"journal-article","created":{"date-parts":[[2017,2,23]],"date-time":"2017-02-23T11:11:17Z","timestamp":1487848277000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Storage of passive motion pattern in hippocampal CA1 region depends on CaMKII\/CREB signaling pathway in a motion sickness rodent model"],"prefix":"10.1038","volume":"7","author":[{"given":"Junqin","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiluo","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leilei","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruirui","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiling","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,2,23]]},"reference":[{"key":"BFsrep43385_CR1","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1177\/014107687807101109","volume":"71","author":"JT Reason","year":"1978","unstructured":"Reason, J. 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