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However, their influence on the progression from elevated serum urate levels to gout is unclear. This study aims to explore systematically the effects of genetic variants on the pathogenesis in approximately 5,000 Chinese individuals. Six genes (<jats:italic>PDZK1, GCKR, TRIM46, HNF4G, SLC17A1, LRRC16A<\/jats:italic>) were determined to be associated with serum urate (<jats:italic>P<\/jats:italic><jats:sub>FDR<\/jats:sub>\u2009&lt;\u20090.05) in the Chinese population for the first time. <jats:italic>ABCG2<\/jats:italic> and a novel gene, <jats:italic>SLC17A4<\/jats:italic>, contributed to the development of gout from hyperuricemia (OR\u2009=\u20091.56, <jats:italic>P<\/jats:italic><jats:sub>FDR<\/jats:sub>\u2009=\u20093.68E-09; OR\u2009=\u20091.27, <jats:italic>P<\/jats:italic><jats:sub>FDR<\/jats:sub>\u2009=\u20090.013, respectively). Also, <jats:italic>HNF4G<\/jats:italic> is a novel gene associated with susceptibility to gout (OR\u2009=\u20091.28, <jats:italic>P<\/jats:italic><jats:sub>FDR<\/jats:sub>\u2009=\u20091.08E-03). In addition, <jats:italic>A1CF<\/jats:italic> and <jats:italic>TRIM46<\/jats:italic> were identified as associated with gout in the Chinese population for the first time (<jats:italic>P<\/jats:italic><jats:sub>FDR<\/jats:sub>\u2009&lt;\u20090.05). The present study systematically determined genetic effects on the progression from elevated serum urate to gout and suggests that urate-associated genes functioning as urate transporters <jats:underline>may<\/jats:underline> play a specific role in the pathogenesis of gout. Furthermore, two novel gout-associated genes (<jats:italic>HNF4G<\/jats:italic> and <jats:italic>SLC17A4<\/jats:italic>) were identified.<\/jats:p>","DOI":"10.1038\/srep43614","type":"journal-article","created":{"date-parts":[[2017,3,2]],"date-time":"2017-03-02T15:37:12Z","timestamp":1488469032000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":53,"title":["Effects of multiple genetic loci on the pathogenesis from serum urate to gout"],"prefix":"10.1038","volume":"7","author":[{"given":"Zheng","family":"Dong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingru","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuai","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongbao","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengde","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanyun","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongjun","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hengdong","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yajun","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofeng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yafei","family":"Pang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hejian","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiucun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,3,2]]},"reference":[{"key":"BFsrep43614_CR1","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1111\/1756-185X.12519","volume":"18","author":"Z Dong","year":"2015","unstructured":"Dong, Z. et al. 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