{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T14:45:48Z","timestamp":1778942748248,"version":"3.51.4"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2017,3,2]],"date-time":"2017-03-02T00:00:00Z","timestamp":1488412800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2017,3,2]],"date-time":"2017-03-02T00:00:00Z","timestamp":1488412800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A key question within systems neuroscience is to understand how the brain encodes spatially and temporally distributed local features and binds these together into one perceptual representation. Previous works in animal and human have shown that changes in neural synchrony occur during the perceptual processing and these changes are distinguished by the emergence of gamma-band oscillations (GBO, 30\u201380\u2009Hz, centered at 40\u2009Hz). Here, we used the mouse electroencephalogram to investigate how different cortical areas play roles in perceptual processing by assessing their GBO patterns during the visual presentation of coherently\/incoherently moving random-dot kinematogram and static dots display. Our results revealed that GBO in the visual cortex were strongly modulated by the moving dots regardless of the existence of a global dot coherence, whereas GBO in frontal cortex were modulated by coherence of the motion. Moreover, concurrent GBO across the multiple cortical area occur more frequently for coherently moving dots. Taken together, these findings of GBO in the mouse frontal and visual cortex are related to the perceptual binding of local features into a globally-coherent representation, suggesting the dynamic interplay across the local\/distributed networks of GBO in the global processing of optic flow.<\/jats:p>","DOI":"10.1038\/srep43780","type":"journal-article","created":{"date-parts":[[2017,3,2]],"date-time":"2017-03-02T10:54:45Z","timestamp":1488452085000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Gamma-Band Activities in Mouse Frontal and Visual Cortex Induced by Coherent Dot Motion"],"prefix":"10.1038","volume":"7","author":[{"given":"Hio-Been","family":"Han","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eunjin","family":"Hwang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soohyun","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min-Shik","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jee Hyun","family":"Choi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2017,3,2]]},"reference":[{"key":"BFsrep43780_CR1","doi-asserted-by":"publisher","first-page":"7152","DOI":"10.1523\/JNEUROSCI.19-16-07152.1999","volume":"19","author":"A Keil","year":"1999","unstructured":"Keil, A., Muller, M. M., Ray, W. J., Gruber, T. & Elbert, T. Human gamma band activity and perception of a gestalt. J. Neurosci. 19, 7152\u20137161 (1999).","journal-title":"J. Neurosci."},{"key":"BFsrep43780_CR2","doi-asserted-by":"publisher","first-page":"1741","DOI":"10.1093\/cercor\/bhl100","volume":"17","author":"E Zion-Golumbic","year":"2007","unstructured":"Zion-Golumbic, E. & Bentin, S. Dissociated neural mechanisms for face detection and configural encoding: evidence from N170 and induced gamma-band oscillation effects. Cereb. Cortex 17, 1741\u20131749, doi: 10.1093\/cercor\/bhl100 (2007).","journal-title":"Cereb. Cortex"},{"key":"BFsrep43780_CR3","doi-asserted-by":"publisher","first-page":"1407","DOI":"10.1016\/j.neuroimage.2007.05.054","volume":"37","author":"D Anaki","year":"2007","unstructured":"Anaki, D., Zion-Golumbic, E. & Bentin, S. Electrophysiological neural mechanisms for detection, configural analysis and recognition of faces. Neuroimage 37, 1407\u20131416, doi: 10.1016\/j.neuroimage.2007.05.054 (2007).","journal-title":"Neuroimage"},{"key":"BFsrep43780_CR4","doi-asserted-by":"publisher","first-page":"4244","DOI":"10.1523\/JNEUROSCI.18-11-04244.1998","volume":"18","author":"C Tallon-Baudry","year":"1998","unstructured":"Tallon-Baudry, C., Bertrand, O., Peronnet, F. & Pernier, J. Induced gamma-band activity during the delay of a visual short-term memory task in humans. J. Neurosci. 18, 4244\u20134254 (1998).","journal-title":"J. Neurosci."},{"key":"BFsrep43780_CR5","doi-asserted-by":"publisher","first-page":"4399","DOI":"10.1073\/pnas.0708418105","volume":"105","author":"P Sehatpour","year":"2008","unstructured":"Sehatpour, P. et al. A human intracranial study of long-range oscillatory coherence across a frontal-occipital-hippocampal brain network during visual object processing. Proc. Natl. Acad. Sci. USA 105, 4399\u20134404, doi: 10.1073\/pnas.0708418105 (2008).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFsrep43780_CR6","doi-asserted-by":"publisher","first-page":"64","DOI":"10.3389\/fnint.2014.00064","volume":"8","author":"M Castellano","year":"2014","unstructured":"Castellano, M., Plochl, M., Vicente, R. & Pipa, G. Neuronal oscillations form parietal\/frontal networks during contour integration. Front. Integr. Neurosci. 8, 64, doi: 10.3389\/fnint.2014.00064 (2014).","journal-title":"Front. Integr. Neurosci"},{"key":"BFsrep43780_CR7","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1016\/j.neuron.2008.09.010","volume":"60","author":"M Siegel","year":"2008","unstructured":"Siegel, M., Donner, T. H., Oostenveld, R., Fries, P. & Engel, A. K. Neuronal synchronization along the dorsal visual pathway reflects the focus of spatial attention. Neuron 60, 709\u2013719, doi: 10.1016\/j.neuron.2008.09.010 (2008).","journal-title":"Neuron"},{"key":"BFsrep43780_CR8","doi-asserted-by":"publisher","first-page":"1207","DOI":"10.1126\/science.1171402","volume":"324","author":"GG Gregoriou","year":"2009","unstructured":"Gregoriou, G. G., Gotts, S. J., Zhou, H. H. & Desimone, R. High-Frequency, Long-Range Coupling Between Prefrontal and Visual Cortex During Attention. Science 324, 1207\u20131210, doi: 10.1126\/science.1171402 (2009).","journal-title":"Science"},{"key":"BFsrep43780_CR9","doi-asserted-by":"publisher","first-page":"744","DOI":"10.1016\/j.biopsych.2007.10.017","volume":"63","author":"KM Spencer","year":"2008","unstructured":"Spencer, K. M., Niznikiewicz, M. A., Shenton, M. E. & McCarley, R. W. Sensory-evoked gamma oscillations in chronic schizophrenia. Biol. Psychiatry 63, 744\u2013747, doi: 10.1016\/j.biopsych.2007.10.017 (2008).","journal-title":"Biol. Psychiatry"},{"key":"BFsrep43780_CR10","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1016\/j.cortex.2011.02.016","volume":"48","author":"TA Stroganova","year":"2012","unstructured":"Stroganova, T. A. et al. High-frequency oscillatory response to illusory contour in typically developing boys and boys with autism spectrum disorders. Cortex 48, 701\u2013717, doi: 10.1016\/j.cortex.2011.02.016 (2012).","journal-title":"Cortex"},{"key":"BFsrep43780_CR11","doi-asserted-by":"publisher","first-page":"9563","DOI":"10.1523\/Jneurosci.1073-12.2012","volume":"32","author":"LM Sun","year":"2012","unstructured":"Sun, L. M. et al. Impaired Gamma-Band Activity during Perceptual Organization in Adults with Autism Spectrum Disorders: Evidence for Dysfunctional Network Activity in Frontal-Posterior Cortices. J. Neurosci. 32, 9563\u20139573, doi: 10.1523\/Jneurosci.1073-12.2012 (2012).","journal-title":"J. Neurosci."},{"key":"BFsrep43780_CR12","doi-asserted-by":"crossref","unstructured":"Peiker, I. et al. Stronger Neural Modulation by Visual Motion Intensity in Autism Spectrum Disorders. PLoS One 10, doi: ARTN e0132531 10.1371\/journal.pone.0132531 (2015).","DOI":"10.1371\/journal.pone.0132531"},{"key":"BFsrep43780_CR13","doi-asserted-by":"publisher","first-page":"732","DOI":"10.1093\/cercor\/bhk025","volume":"17","author":"M Siegel","year":"2007","unstructured":"Siegel, M., Donner, T. H., Oostenveld, R., Fries, P. & Engel, A. K. High-frequency activity in human visual cortex is modulated by visual motion strength. Cereb. Cortex 17, 732\u2013741, doi: 10.1093\/cercor\/bhk025 (2007).","journal-title":"Cereb. Cortex"},{"key":"BFsrep43780_CR14","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1097\/00001756-200504250-00022","volume":"16","author":"GP Krishnan","year":"2005","unstructured":"Krishnan, G. P., Skosnik, P. D., Vohs, J. L., Busey, T. A. & O\u2019Donnell, B. F. Relationship between steady-state and induced gamma activity to motion. Neuroreport 16, 625\u2013630, doi: 10.1097\/00001756-200504250-00022 (2005).","journal-title":"Neuroreport"},{"key":"BFsrep43780_CR15","doi-asserted-by":"publisher","first-page":"3087","DOI":"10.1038\/npp.2014.166","volume":"39","author":"PD Skosnik","year":"2014","unstructured":"Skosnik, P. D., Krishnan, G. P., D\u2019Souza, D. C., Hetrick, W. P. & O\u2019Donnell, B. F. Disrupted gamma-band neural oscillations during coherent motion perception in heavy cannabis users. Neuropsychopharmacology 39, 3087\u20133099, doi: 10.1038\/npp.2014.166 (2014).","journal-title":"Neuropsychopharmacology"},{"key":"BFsrep43780_CR16","doi-asserted-by":"publisher","first-page":"2588","DOI":"10.1093\/brain\/awu189","volume":"137","author":"CE Robertson","year":"2014","unstructured":"Robertson, C. E. et al. Global motion perception deficits in autism are reflected as early as primary visual cortex. Brain 137, 2588\u20132599, doi: 10.1093\/brain\/awu189 (2014).","journal-title":"Brain"},{"key":"BFsrep43780_CR17","doi-asserted-by":"publisher","first-page":"695","DOI":"10.3233\/JAD-2011-110167","volume":"28","author":"T Yamasaki","year":"2012","unstructured":"Yamasaki, T. et al. Selective impairment of optic flow perception in amnestic mild cognitive impairment: evidence from event-related potentials. J. Alzheimers Dis. 28, 695\u2013708, doi: 10.3233\/JAD-2011-110167 (2012).","journal-title":"J. Alzheimers Dis."},{"key":"BFsrep43780_CR18","doi-asserted-by":"publisher","first-page":"2842","DOI":"10.1016\/j.visres.2006.02.025","volume":"46","author":"RM Douglas","year":"2006","unstructured":"Douglas, R. M., Neve, A., Quittenbaum, J. P., Alam, N. M. & Prusky, G. T. Perception of visual motion coherence by rats and mice. Vision Res. 46, 2842\u20132847, doi: 10.1016\/j.visres.2006.02.025 (2006).","journal-title":"Vision Res."},{"key":"BFsrep43780_CR19","doi-asserted-by":"publisher","first-page":"1115","DOI":"10.1152\/jn.00480.2002","volume":"90","author":"G Nase","year":"2003","unstructured":"Nase, G., Singer, W., Monyer, H. & Engel, A. K. Features of neuronal synchrony in mouse visual cortex. J. Neurophysiol. 90, 1115\u20131123, doi: 10.1152\/jn.00480.2002 (2003).","journal-title":"J. Neurophysiol."},{"key":"BFsrep43780_CR20","doi-asserted-by":"publisher","first-page":"5912","DOI":"10.1523\/JNEUROSCI.6456-09.2010","volume":"30","author":"E Gao","year":"2010","unstructured":"Gao, E., DeAngelis, G. C. & Burkhalter, A. Parallel input channels to mouse primary visual cortex. J. Neurosci. 30, 5912\u20135926, doi: 10.1523\/JNEUROSCI.6456-09.2010 (2010).","journal-title":"J. Neurosci."},{"key":"BFsrep43780_CR21","unstructured":"Paxinos, G. & Franklin, K. B. J. The mouse brain in stereotaxic coordinates (2nd edn) (Academic Press, 2001)."},{"key":"BFsrep43780_CR22","doi-asserted-by":"crossref","unstructured":"Guo, Z. C. V. et al. Procedures for Behavioral Experiments in Head-Fixed Mice. PLoS One 9, doi: ARTN e88678 10.1371\/journal.pone.0088678 (2014).","DOI":"10.1371\/journal.pone.0088678"},{"key":"BFsrep43780_CR23","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1163\/156856897X00357","volume":"10","author":"DH Brainard","year":"1997","unstructured":"Brainard, D. H. The Psychophysics Toolbox. Spat. Vis. 10, 433\u2013436 (1997).","journal-title":"Spat. Vis"},{"key":"BFsrep43780_CR24","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1016\/j.jphysparis.2003.09.009","volume":"97","author":"C Tallon-Baudry","year":"2003","unstructured":"Tallon-Baudry, C. Oscillatory synchrony and human visual cognition. J. Physiol. Paris 97, 355\u2013363, doi: 10.1016\/j.jphysparis.2003.09.009 (2003).","journal-title":"J. Physiol. Paris"},{"key":"BFsrep43780_CR25","doi-asserted-by":"crossref","unstructured":"Galambos, R. A comparison of certain gamma band (40-Hz) brain rhythms in cat and man In Induced rhythms in the brain (ed. Ba\u015far, E. & Bullock T. H. ) 201\u2013216 (Birkh\u00e4user, 1992).","DOI":"10.1007\/978-1-4757-1281-0_11"},{"key":"BFsrep43780_CR26","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/j.tics.2011.03.007","volume":"15","author":"TH Donner","year":"2011","unstructured":"Donner, T. H. & Siegel, M. A framework for local cortical oscillation patterns. Trends. Cogn. Sci. 15, 191\u2013199, doi: 10.1016\/j.tics.2011.03.007 (2011).","journal-title":"Trends. Cogn. Sci."},{"key":"BFsrep43780_CR27","doi-asserted-by":"crossref","unstructured":"Siegel, M. & Donner T. H. Linking band-limited cortical population activity to fMRI and behavior In Simultaneous EEG and fMRI: Recording, Analysis, and Application (ed. Ullsperger, M. & Debener, S. ) 271\u2013294 (Oxford University Press, 2010).","DOI":"10.1093\/acprof:oso\/9780195372731.003.0017"},{"key":"BFsrep43780_CR28","doi-asserted-by":"publisher","first-page":"88","DOI":"10.2307\/2684253","volume":"48","author":"F Pukelsheim","year":"1994","unstructured":"Pukelsheim, F. The 3-Sigma-Rule. Am. Stat. 48, 88\u201391, doi: Doi 10.2307\/2684253 (1994).","journal-title":"Am. Stat."},{"key":"BFsrep43780_CR29","doi-asserted-by":"publisher","first-page":"2059","DOI":"10.1097\/00001756-199510010-00025","volume":"6","author":"F Pulvermuller","year":"1995","unstructured":"Pulvermuller, F., Lutzenberger, W., Preissl, H. & Birbaumer, N. Spectral responses in the gamma-band: physiological signs of higher cognitive processes? Neuroreport 6, 2059\u20132064 (1995).","journal-title":"Neuroreport"},{"key":"BFsrep43780_CR30","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/S1364-6613(99)01299-1","volume":"3","author":"C Tallon-Baudry","year":"1999","unstructured":"Tallon-Baudry, C. & Bertrand, O. Oscillatory gamma activity in humans and its role in object representation. Trends. Cogn. Sci. 3, 151\u2013162 (1999).","journal-title":"Trends. Cogn. Sci."},{"key":"BFsrep43780_CR31","doi-asserted-by":"publisher","first-page":"2074","DOI":"10.1016\/S1388-2457(99)00176-5","volume":"110","author":"T Gruber","year":"1999","unstructured":"Gruber, T., Muller, M. M., Keil, A. & Elbert, T. Selective visual-spatial attention alters induced gamma band responses in the human EEG. Clin. Neurophysiol. 110, 2074\u20132085 (1999).","journal-title":"Clin. Neurophysiol"},{"key":"BFsrep43780_CR32","doi-asserted-by":"publisher","first-page":"1560","DOI":"10.1126\/science.291.5508.1560","volume":"291","author":"P Fries","year":"2001","unstructured":"Fries, P., Reynolds, J. H., Rorie, A. E. & Desimone, R. Modulation of oscillatory neuronal synchronization by selective visual attention. Science 291, 1560\u20131563, doi: 10.1126\/science.291.5508.1560 (2001).","journal-title":"Science"},{"key":"BFsrep43780_CR33","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1126\/science.1109676","volume":"308","author":"NP Bichot","year":"2005","unstructured":"Bichot, N. P., Rossi, A. F. & Desimone, R. Parallel and serial neural mechanisms for visual search in macaque area V4. Science 308, 529\u2013534, doi: 10.1126\/science.1109676 (2005).","journal-title":"Science"},{"key":"BFsrep43780_CR34","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/S1364-6613(00)01568-0","volume":"5","author":"AK Engel","year":"2001","unstructured":"Engel, A. K. & Singer, W. Temporal binding and the neural correlates of sensory awareness. Trends. Cogn. Sci. 5, 16\u201325 (2001).","journal-title":"Trends. Cogn. Sci."},{"key":"BFsrep43780_CR35","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1016\/S1364-6613(99)01332-7","volume":"3","author":"DA Leopold","year":"1999","unstructured":"Leopold, D. A. & Logothetis, N. K. Multistable phenomena: Changing views in perception. Trends. Cogn. Sci. 3, 254\u2013264, doi: 10.1016\/S1364-6613(99)01332-7 (1999).","journal-title":"Trends. Cogn. Sci."},{"key":"BFsrep43780_CR36","doi-asserted-by":"publisher","first-page":"e66363","DOI":"10.1371\/journal.pone.0066363","volume":"8","author":"J Castelhano","year":"2013","unstructured":"Castelhano, J., Rebola, J., Leitao, B., Rodriguez, E. & Castelo-Branco, M. To perceive or not perceive: the role of gamma-band activity in signaling object percepts. PloS one 8, e66363, doi: 10.1371\/journal.pone.0066363 (2013).","journal-title":"PloS one"},{"key":"BFsrep43780_CR37","doi-asserted-by":"crossref","unstructured":"Mostert, P., Kok, P. & de Lange, F. P. Dissociating sensory from decision processes in human perceptual decision making. Sci. Rep. 5, doi: ARTN 18253 10.1038\/srep18253 (2015).","DOI":"10.1038\/srep18253"},{"key":"BFsrep43780_CR38","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/j.neuron.2006.09.020","volume":"52","author":"PJ Uhlhaas","year":"2006","unstructured":"Uhlhaas, P. J. & Singer, W. Neural synchrony in brain disorders: relevance for cognitive dysfunctions and pathophysiology. Neuron 52, 155\u2013168, doi: 10.1016\/j.neuron.2006.09.020 (2006).","journal-title":"Neuron"},{"key":"BFsrep43780_CR39","doi-asserted-by":"publisher","first-page":"6449","DOI":"10.1523\/JNEUROSCI.6144-10.2011","volume":"31","author":"K Dzirasa","year":"2011","unstructured":"Dzirasa, K. et al. Impaired limbic gamma oscillatory synchrony during anxiety-related behavior in a genetic mouse model of bipolar mania. J. Neurosci. 31, 6449\u20136456, doi: 10.1523\/JNEUROSCI.6144-10.2011 (2011).","journal-title":"J. Neurosci."},{"key":"BFsrep43780_CR40","doi-asserted-by":"publisher","first-page":"439","DOI":"10.3109\/15622975.2015.1112036","volume":"17","author":"Y Shahriari","year":"2016","unstructured":"Shahriari, Y. et al. Impaired auditory evoked potentials and oscillations in frontal and auditory cortex of a schizophrenia mouse model. World J. Biol. Psychiatry. 17, 439\u2013448, doi: 10.3109\/15622975.2015.1112036 (2016).","journal-title":"World J. Biol. Psychiatry."},{"key":"BFsrep43780_CR41","doi-asserted-by":"publisher","first-page":"824","DOI":"10.1038\/nn.3410","volume":"16","author":"M Carandini","year":"2013","unstructured":"Carandini, M. & Churchland, A. K. Probing perceptual decisions in rodents. Nat. Neurosci. 16, 824\u2013831, doi: 10.1038\/nn.3410 (2013).","journal-title":"Nat. Neurosci."},{"key":"BFsrep43780_CR42","doi-asserted-by":"publisher","first-page":"1825","DOI":"10.1152\/jn.00188.2010","volume":"104","author":"JH Choi","year":"2010","unstructured":"Choi, J. H., Koch, K. P., Poppendieck, W., Lee, M. & Shin, H. S. High resolution electroencephalography in freely moving mice. J. Neurophysiol. 104, 1825\u20131834, doi: 10.1152\/jn.00188.2010 (2010).","journal-title":"J. Neurophysiol."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/srep43780.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/srep43780","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/srep43780.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,24]],"date-time":"2022-12-24T00:42:35Z","timestamp":1671842555000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/srep43780"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3,2]]},"references-count":42,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2017,3,20]]}},"alternative-id":["BFsrep43780"],"URL":"https:\/\/doi.org\/10.1038\/srep43780","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3,2]]},"assertion":[{"value":"18 October 2016","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 January 2017","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 March 2017","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing financial interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"43780"}}