{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T16:18:49Z","timestamp":1789921129852,"version":"4.0.1"},"reference-count":54,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2017,3,7]],"date-time":"2017-03-07T00:00:00Z","timestamp":1488844800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2017,3,7]],"date-time":"2017-03-07T00:00:00Z","timestamp":1488844800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Maintaining stemness of leukemic stem cells (LSCs) and reciprocal interactions between leukemia and stromal cells support leukemic progression and resistance to chemotherapy. Targeting the niche-based microenvironment is thus a new approach for leukemia therapy. Cordycepin is an analogue of adenosine and has been suggested to possess anti-leukemia properties. However, whether cordycepin influences association of leukemia and mesenchymal stromal cells has never been investigated. Here we show that cordycepin reduces CD34<jats:sup>+<\/jats:sup>CD38<jats:sup>\u2212<\/jats:sup> cells in U937 and K562 cells and induces Dkk1 expression via autocrine and paracrine regulation in leukemia and mesenchymal stromal\/stem cells (MSCs). Cordycepin suppresses cell attachment of leukemia with MSCs and downregulates N-cadherin in leukemia and VCAM-1 in MSCs. Moreover, incubation with leukemic conditioned media (CM) significantly induces IL-8 and IL-6 expression in MSCs, which is abrogated by cordycepin. Suppression of leukemic CM-induced VCAM-1 and IL-8 by cordycepin in MSCs is mediated by impairing NF\u03baB signaling. Finally, cordycepin combined with an adenosine deaminase inhibitor prolongs survival in a leukemic mouse model. Our results indicate that cordycepin is a potential anti-leukemia therapeutic adjuvant via eliminating LSCs and disrupting leukemia-stromal association.<\/jats:p>","DOI":"10.1038\/srep43930","type":"journal-article","created":{"date-parts":[[2017,3,7]],"date-time":"2017-03-07T10:41:42Z","timestamp":1488883302000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Cordycepin disrupts leukemia association with mesenchymal stromal cells and eliminates leukemia stem cell activity"],"prefix":"10.1038","volume":"7","author":[{"given":"Shu-Man","family":"Liang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Jhu","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bor-Sheng","family":"Ko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yee-Jee","family":"Jan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song-Kun","family":"Shyue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaw-Fang","family":"Yet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun-Yang","family":"Liou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,3,7]]},"reference":[{"key":"BFsrep43930_CR1","doi-asserted-by":"publisher","first-page":"1650","DOI":"10.1126\/science.1186624","volume":"327","author":"Y Wang","year":"2010","unstructured":"Wang, Y. et al. The Wnt\/beta-catenin pathway is required for the development of leukemia stem cells in AML. Science 327, 1650\u20131653 (2010).","journal-title":"Science"},{"key":"BFsrep43930_CR2","doi-asserted-by":"publisher","first-page":"1211","DOI":"10.1038\/sj.leu.2404239","volume":"20","author":"L Ysebaert","year":"2006","unstructured":"Ysebaert, L. et al. Expression of beta-catenin by acute myeloid leukemia cells predicts enhanced clonogenic capacities and poor prognosis. Leukemia 20, 1211\u20131216 (2006).","journal-title":"Leukemia"},{"key":"BFsrep43930_CR3","doi-asserted-by":"publisher","first-page":"2326","DOI":"10.1056\/NEJMcibr1003522","volume":"362","author":"CJ Eaves","year":"2010","unstructured":"Eaves, C. J. & Humphries, R. K. Acute myeloid leukemia and the Wnt pathway. N. Engl. J. Med. 362, 2326\u20132327 (2010).","journal-title":"N. Engl. J. Med."},{"key":"BFsrep43930_CR4","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1016\/j.stem.2012.03.006","volume":"10","author":"M Kleppe","year":"2012","unstructured":"Kleppe, M. & Levine, R. L. Targeting beta-catenin in CML: leukemia stem cells beware! Cell Stem Cell 10, 351\u2013353 (2012).","journal-title":"Cell Stem Cell"},{"key":"BFsrep43930_CR5","doi-asserted-by":"publisher","first-page":"528","DOI":"10.1016\/j.ccr.2007.11.003","volume":"12","author":"C Zhao","year":"2007","unstructured":"Zhao, C. et al. Loss of beta-catenin impairs the renewal of normal and CML stem cells in vivo . Cancer Cell 12, 528\u2013541 (2007).","journal-title":"Cancer Cell"},{"key":"BFsrep43930_CR6","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1016\/j.stem.2012.02.017","volume":"10","author":"FH Heidel","year":"2012","unstructured":"Heidel, F. H. et al. Genetic and pharmacologic inhibition of beta-catenin targets imatinib-resistant leukemia stem cells in CML. Cell Stem Cell 10, 412\u2013424 (2012).","journal-title":"Cell Stem Cell"},{"key":"BFsrep43930_CR7","doi-asserted-by":"publisher","first-page":"2254","DOI":"10.1172\/JCI41246","volume":"120","author":"D Perrotti","year":"2010","unstructured":"Perrotti, D., Jamieson, C., Goldman, J. & Skorski, T. Chronic myeloid leukemia: mechanisms of blastic transformation. J. Clin. Invest. 120, 2254\u20132264 (2010).","journal-title":"J. Clin. Invest."},{"key":"BFsrep43930_CR8","doi-asserted-by":"publisher","first-page":"1456","DOI":"10.1038\/sj.emboj.7601485","volume":"26","author":"AM Coluccia","year":"2007","unstructured":"Coluccia, A. M. et al. Bcr-Abl stabilizes beta-catenin in chronic myeloid leukemia through its tyrosine phosphorylation. EMBO J. 26, 1456\u20131466 (2007).","journal-title":"EMBO J."},{"key":"BFsrep43930_CR9","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1038\/leu.2008.262","volume":"23","author":"Y Hu","year":"2009","unstructured":"Hu, Y., Chen, Y., Douglas, L. & Li, S. beta-Catenin is essential for survival of leukemic stem cells insensitive to kinase inhibition in mice with BCR-ABL-induced chronic myeloid leukemia. Leukemia 23, 109\u2013116 (2009).","journal-title":"Leukemia"},{"key":"BFsrep43930_CR10","doi-asserted-by":"publisher","first-page":"2849","DOI":"10.1182\/blood-2011-03-345165","volume":"118","author":"SW Lane","year":"2011","unstructured":"Lane, S. W. et al. Differential niche and Wnt requirements during acute myeloid leukemia progression. Blood 118, 2849\u20132856 (2011).","journal-title":"Blood"},{"key":"BFsrep43930_CR11","doi-asserted-by":"publisher","first-page":"951","DOI":"10.1016\/S0960-9822(01)00290-1","volume":"11","author":"MV Semenov","year":"2001","unstructured":"Semenov, M. V. et al. Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6. Curr. Biol. 11, 951\u2013961 (2001).","journal-title":"Curr. Biol."},{"key":"BFsrep43930_CR12","doi-asserted-by":"publisher","first-page":"8520","DOI":"10.1038\/sj.onc.1207892","volume":"23","author":"A Niida","year":"2004","unstructured":"Niida, A. et al. DKK1, a negative regulator of Wnt signaling, is a target of the beta-catenin\/TCF pathway. Oncogene 23, 8520\u20138526 (2004).","journal-title":"Oncogene"},{"key":"BFsrep43930_CR13","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1038\/nrm3049","volume":"12","author":"C Nombela-Arrieta","year":"2011","unstructured":"Nombela-Arrieta, C., Ritz, J. & Silberstein, L. E. The elusive nature and function of mesenchymal stem cells. Nat. Rev. Mol. Cell Biol. 12, 126\u2013131 (2011).","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"BFsrep43930_CR14","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1038\/nature09262","volume":"466","author":"S Mendez-Ferrer","year":"2010","unstructured":"Mendez-Ferrer, S. et al. Mesenchymal and haematopoietic stem cells form a unique bone marrow niche. Nature 466, 829\u2013834 (2010).","journal-title":"Nature"},{"key":"BFsrep43930_CR15","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1038\/nrm3184","volume":"12","author":"LD Wang","year":"2011","unstructured":"Wang, L. D. & Wagers, A. J. Dynamic niches in the origination and differentiation of haematopoietic stem cells. Nat. Rev. Mol. Cell Biol. 12, 643\u2013655 (2011).","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"BFsrep43930_CR16","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1084\/jem.20110132","volume":"208","author":"A Ehninger","year":"2011","unstructured":"Ehninger, A. & Trumpp, A. The bone marrow stem cell niche grows up: mesenchymal stem cells and macrophages move in. J. Exp. Med. 208, 421\u2013428 (2011).","journal-title":"J. Exp. Med."},{"key":"BFsrep43930_CR17","doi-asserted-by":"publisher","first-page":"1150","DOI":"10.1182\/blood-2009-01-202606","volume":"114","author":"SW Lane","year":"2009","unstructured":"Lane, S. W., Scadden, D. T. & Gilliland, D. G. The leukemic stem cell niche: current concepts and therapeutic opportunities. Blood 114, 1150\u20131157 (2009).","journal-title":"Blood"},{"key":"BFsrep43930_CR18","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1200\/JCO.2010.31.0904","volume":"29","author":"MY Konopleva","year":"2011","unstructured":"Konopleva, M. Y. & Jordan, C. T. Leukemia stem cells and microenvironment: biology and therapeutic targeting. J. Clin. Oncol. 29, 591\u2013599 (2011).","journal-title":"J. Clin. Oncol."},{"key":"BFsrep43930_CR19","doi-asserted-by":"publisher","first-page":"1861","DOI":"10.1126\/science.1164390","volume":"322","author":"A Colmone","year":"2008","unstructured":"Colmone, A. et al. Leukemic cells create bone marrow niches that disrupt the behavior of normal hematopoietic progenitor cells. Science 322, 1861\u20131865 (2008).","journal-title":"Science"},{"key":"BFsrep43930_CR20","doi-asserted-by":"publisher","first-page":"925","DOI":"10.1038\/leu.2008.384","volume":"23","author":"Y Zhu","year":"2009","unstructured":"Zhu, Y. et al. Human mesenchymal stem cells inhibit cancer cell proliferation by secreting DKK-1. Leukemia 23, 925\u2013933 (2009).","journal-title":"Leukemia"},{"key":"BFsrep43930_CR21","doi-asserted-by":"publisher","first-page":"1158","DOI":"10.1038\/nm909","volume":"9","author":"T Matsunaga","year":"2003","unstructured":"Matsunaga, T. et al. Interaction between leukemic-cell VLA-4 and stromal fibronectin is a decisive factor for minimal residual disease of acute myelogenous leukemia. Nat. Med. 9, 1158\u20131165 (2003).","journal-title":"Nat. Med"},{"key":"BFsrep43930_CR22","doi-asserted-by":"publisher","first-page":"2691","DOI":"10.1182\/blood-2013-06-511527","volume":"123","author":"R Jacamo","year":"2014","unstructured":"Jacamo, R. et al. Reciprocal leukemia-stroma VCAM-1\/VLA-4-dependent activation of NF-kappaB mediates chemoresistance. Blood 123, 2691\u20132702 (2014).","journal-title":"Blood"},{"key":"BFsrep43930_CR23","doi-asserted-by":"publisher","first-page":"1824","DOI":"10.1182\/blood-2012-02-412890","volume":"121","author":"B Zhang","year":"2013","unstructured":"Zhang, B. et al. Microenvironmental protection of CML stem and progenitor cells from tyrosine kinase inhibitors through N-cadherin and Wnt-beta-catenin signaling. Blood 121, 1824\u20131838 (2013).","journal-title":"Blood"},{"key":"BFsrep43930_CR24","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/j.ccr.2006.08.020","volume":"10","author":"TC Somervaille","year":"2006","unstructured":"Somervaille, T. C. & Cleary, M. L. Identification and characterization of leukemia stem cells in murine MLL-AF9 acute myeloid leukemia. Cancer Cell 10, 257\u2013268 (2006).","journal-title":"Cancer Cell"},{"key":"BFsrep43930_CR25","doi-asserted-by":"publisher","first-page":"1789","DOI":"10.1038\/leu.2011.145","volume":"25","author":"M Despeaux","year":"2011","unstructured":"Despeaux, M. et al. Critical features of FAK-expressing AML bone marrow microenvironment through leukemia stem cell hijacking of mesenchymal stromal cells. Leukemia 25, 1789\u20131793 (2011).","journal-title":"Leukemia"},{"key":"BFsrep43930_CR26","doi-asserted-by":"publisher","first-page":"18411","DOI":"10.1038\/srep18411","volume":"5","author":"A Kuett","year":"2015","unstructured":"Kuett, A. et al. IL-8 as mediator in the microenvironment-leukaemia network in acute myeloid leukaemia. Sci. Rep. 5, 18411 (2015).","journal-title":"Sci. Rep"},{"key":"BFsrep43930_CR27","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.canlet.2014.03.009","volume":"348","author":"C Corrado","year":"2014","unstructured":"Corrado, C. et al. Exosome-mediated crosstalk between chronic myelogenous leukemia cells and human bone marrow stromal cells triggers an interleukin 8-dependent survival of leukemia cells. Cancer Lett. 348, 71\u201376 (2014).","journal-title":"Cancer Lett."},{"key":"BFsrep43930_CR28","doi-asserted-by":"publisher","first-page":"3144","DOI":"10.1182\/blood-2015-01-621631","volume":"125","author":"C Schinke","year":"2015","unstructured":"Schinke, C. et al. IL8-CXCR2 pathway inhibition as a therapeutic strategy against MDS and AML stem cells. Blood 125, 3144\u20133152 (2015).","journal-title":"Blood"},{"key":"BFsrep43930_CR29","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1016\/j.ccr.2011.10.012","volume":"20","author":"D Reynaud","year":"2011","unstructured":"Reynaud, D. et al. IL-6 controls leukemic multipotent progenitor cell fate and contributes to chronic myelogenous leukemia development. Cancer Cell 20, 661\u2013673 (2011).","journal-title":"Cancer Cell"},{"key":"BFsrep43930_CR30","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.jep.2004.09.029","volume":"96","author":"EJ Buenz","year":"2005","unstructured":"Buenz, E. J., Bauer, B. A., Osmundson, T. W. & Motley, T. J. The traditional Chinese medicine Cordyceps sinensis and its effects on apoptotic homeostasis. J. Ethnopharmacol. 96, 19\u201329 (2005).","journal-title":"J. Ethnopharmacol."},{"key":"BFsrep43930_CR31","doi-asserted-by":"publisher","first-page":"1469","DOI":"10.1016\/j.phytochem.2008.01.027","volume":"69","author":"RR Paterson","year":"2008","unstructured":"Paterson, R. R. Cordyceps: a traditional Chinese medicine and another fungal therapeutic biofactory? Phytochemistry 69, 1469\u20131495 (2008).","journal-title":"Phytochemistry"},{"key":"BFsrep43930_CR32","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1016\/S0006-2952(99)00325-1","volume":"59","author":"EN Kodama","year":"2000","unstructured":"Kodama, E. N., McCaffrey, R. P., Yusa, K. & Mitsuya, H. Antileukemic activity and mechanism of action of cordycepin against terminal deoxynucleotidyl transferase-positive (TdT+) leukemic cells. Biochem. Pharmacol. 59, 273\u2013281 (2000).","journal-title":"Biochem. Pharmacol."},{"key":"BFsrep43930_CR33","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1248\/cpb.57.411","volume":"57","author":"H Matsuda","year":"2009","unstructured":"Matsuda, H. et al. Apoptosis-inducing effects of sterols from the dried powder of cultured mycelium of Cordyceps sinensis. Chem. Pharm. Bull. (Tokyo) 57, 411\u2013414 (2009).","journal-title":"Chem. Pharm. Bull. (Tokyo)"},{"key":"BFsrep43930_CR34","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1016\/j.tiv.2011.02.001","volume":"25","author":"JW Jeong","year":"2011","unstructured":"Jeong, J. W. et al. Induction of apoptosis by cordycepin via reactive oxygen species generation in human leukemia cells. Toxicol. In Vitro 25, 817\u2013824 (2011).","journal-title":"Toxicol. In Vitro"},{"key":"BFsrep43930_CR35","doi-asserted-by":"publisher","first-page":"e76320","DOI":"10.1371\/journal.pone.0076320","volume":"8","author":"BS Ko","year":"2013","unstructured":"Ko, B. S. et al. Cordycepin regulates GSK-3beta\/beta-catenin signaling in human leukemia cells. PLoS One 8, e76320 (2013).","journal-title":"PLoS One"},{"key":"BFsrep43930_CR36","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1080\/15384101.2014.1000097","volume":"14","author":"Y Liao","year":"2015","unstructured":"Liao, Y. et al. Cordycepin induces cell cycle arrest and apoptosis by inducing DNA damage and up-regulation of p53 in Leukemia cells. Cell Cycle 14, 761\u2013771 (2015).","journal-title":"Cell Cycle"},{"key":"BFsrep43930_CR37","doi-asserted-by":"publisher","first-page":"4462","DOI":"10.3892\/mmr.2015.3928","volume":"12","author":"X Chen","year":"2015","unstructured":"Chen, X. et al. Synergistic effect of HMGB1 knockdown and cordycepin in the K562 human chronic myeloid leukemia cell line. Mol Med Rep 12, 4462\u20134468 (2015).","journal-title":"Mol Med Rep"},{"key":"BFsrep43930_CR38","doi-asserted-by":"publisher","first-page":"4638","DOI":"10.1021\/jf100269g","volume":"58","author":"YJ Tsai","year":"2010","unstructured":"Tsai, Y. J., Lin, L. C. & Tsai, T. H. Pharmacokinetics of adenosine and cordycepin, a bioactive constituent of Cordyceps sinensis in rat. J. Agric. Food Chem. 58, 4638\u20134643 (2010).","journal-title":"J. Agric. Food Chem."},{"key":"BFsrep43930_CR39","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1016\/0006-2952(75)90245-2","volume":"24","author":"RP Agarwal","year":"1975","unstructured":"Agarwal, R. P., Sagar, S. M. & Parks, R. E., Jr. Adenosine deaminase from human erythrocytes: purification and effects of adenosine analogs. Biochem. Pharmacol. 24, 693\u2013701 (1975).","journal-title":"Biochem. Pharmacol."},{"key":"BFsrep43930_CR40","doi-asserted-by":"publisher","first-page":"1441","DOI":"10.1016\/0006-2952(76)90121-0","volume":"25","author":"DG Johns","year":"1976","unstructured":"Johns, D. G. & Adamson, R. H. Enhancement of the biological activity of cordycepin (3\u2032-deoxyadenosine) by the adenosine deaminase inhibitor 2\u2032-deoxycoformycin. Biochem. Pharmacol. 25, 1441\u20131444 (1976).","journal-title":"Biochem. Pharmacol."},{"key":"BFsrep43930_CR41","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/0006-291X(83)90980-4","volume":"115","author":"MS Chapekar","year":"1983","unstructured":"Chapekar, M. S. & Glazer, R. I. Cordycepin analog of (A2\u2032p)2A: evidence that it functions as a prodrug of cordycepin. Biochem. Biophys. Res. Commun. 115, 137\u2013143 (1983).","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"BFsrep43930_CR42","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1006\/taap.1997.8264","volume":"147","author":"LE Rodman","year":"1997","unstructured":"Rodman, L. E. et al. Toxicity of cordycepin in combination with the adenosine deaminase inhibitor 2\u2032-deoxycoformycin in beagle dogs. Toxicol. Appl. Pharmacol. 147, 39\u201345 (1997).","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"BFsrep43930_CR43","first-page":"31","volume":"14","author":"FM Foss","year":"2000","unstructured":"Foss, F. M. Combination therapy with purine nucleoside analogs. Oncology (Williston Park) 14, 31\u201335 (2000).","journal-title":"Oncology (Williston Park)"},{"key":"BFsrep43930_CR44","doi-asserted-by":"crossref","unstructured":"Wu, P. K. et al. The anti-tumor effects of cordycepin-loaded liposomes on the growth of hepatoma 22 tumors in mice and human hepatoma BEL-7402 cells in culture. Drug Dev. Ind. Pharm., 1\u201310 (2016).","DOI":"10.3109\/03639045.2016.1141930"},{"key":"BFsrep43930_CR45","doi-asserted-by":"publisher","first-page":"730","DOI":"10.1038\/nm0797-730","volume":"3","author":"D Bonnet","year":"1997","unstructured":"Bonnet, D. & Dick, J. E. Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nat. Med. 3, 730\u2013737 (1997).","journal-title":"Nat. Med"},{"key":"BFsrep43930_CR46","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1038\/367645a0","volume":"367","author":"T Lapidot","year":"1994","unstructured":"Lapidot, T. et al. A cell initiating human acute myeloid leukaemia after transplantation into SCID mice. Nature 367, 645\u2013648 (1994).","journal-title":"Nature"},{"key":"BFsrep43930_CR47","doi-asserted-by":"publisher","first-page":"740","DOI":"10.1016\/j.ccr.2011.05.007","volume":"19","author":"T Schmidt","year":"2011","unstructured":"Schmidt, T. et al. Loss or inhibition of stromal-derived PlGF prolongs survival of mice with imatinib-resistant Bcr-Abl1(+) leukemia. Cancer Cell 19, 740\u2013753 (2011).","journal-title":"Cancer Cell"},{"key":"BFsrep43930_CR48","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/j.ccr.2009.12.041","volume":"17","author":"N Erez","year":"2010","unstructured":"Erez, N., Truitt, M., Olson, P., Arron, S. T. & Hanahan, D. Cancer-Associated Fibroblasts Are Activated in Incipient Neoplasia to Orchestrate Tumor-Promoting Inflammation in an NF-kappaB-Dependent Manner. Cancer Cell 17, 135\u2013147 (2010).","journal-title":"Cancer Cell"},{"key":"BFsrep43930_CR49","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.ccr.2012.12.003","volume":"23","author":"G Lutzny","year":"2013","unstructured":"Lutzny, G. et al. Protein kinase c-beta-dependent activation of NF-kappaB in stromal cells is indispensable for the survival of chronic lymphocytic leukemia B cells in vivo . Cancer Cell 23, 77\u201392 (2013).","journal-title":"Cancer Cell"},{"key":"BFsrep43930_CR50","doi-asserted-by":"publisher","first-page":"3191","DOI":"10.1158\/0008-5472.CAN-03-3005","volume":"64","author":"C Recher","year":"2004","unstructured":"Recher, C. et al. Expression of focal adhesion kinase in acute myeloid leukemia is associated with enhanced blast migration, increased cellularity, and poor prognosis. Cancer Res. 64, 3191\u20133197 (2004).","journal-title":"Cancer Res."},{"key":"BFsrep43930_CR51","doi-asserted-by":"publisher","first-page":"29","DOI":"10.2174\/18715206113139990305","volume":"14","author":"WL Yao","year":"2014","unstructured":"Yao, W. L. et al. Cordycepin suppresses integrin\/FAK signaling and epithelial-mesenchymal transition in hepatocellular carcinoma. Anticancer Agents Med. Chem. 14, 29\u201334 (2014).","journal-title":"Anticancer Agents Med. Chem"},{"key":"BFsrep43930_CR52","doi-asserted-by":"publisher","first-page":"3645","DOI":"10.1016\/j.biomaterials.2009.03.032","volume":"30","author":"DM Huang","year":"2009","unstructured":"Huang, D. M. et al. The promotion of human mesenchymal stem cell proliferation by superparamagnetic iron oxide nanoparticles. Biomaterials 30, 3645\u20133651 (2009).","journal-title":"Biomaterials"},{"key":"BFsrep43930_CR53","doi-asserted-by":"publisher","first-page":"2014","DOI":"10.1096\/fj.05-4288fje","volume":"19","author":"DM Huang","year":"2005","unstructured":"Huang, D. M. et al. Highly efficient cellular labeling of mesoporous nanoparticles in human mesenchymal stem cells: implication for stem cell tracking. FASEB J. 19, 2014\u20132016 (2005).","journal-title":"FASEB J"},{"key":"BFsrep43930_CR54","first-page":"827","volume":"7","author":"A Cesano","year":"1992","unstructured":"Cesano, A. et al. The severe combined immunodeficient (SCID) mouse as a model for human myeloid leukemias. Oncogene 7, 827\u2013836 (1992).","journal-title":"Oncogene"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/srep43930","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/srep43930.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/srep43930.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,23]],"date-time":"2022-12-23T19:03:31Z","timestamp":1671822211000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/srep43930"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3,7]]},"references-count":54,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2017,4,28]]}},"alternative-id":["BFsrep43930"],"URL":"https:\/\/doi.org\/10.1038\/srep43930","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3,7]]},"assertion":[{"value":"9 August 2016","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 January 2017","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 March 2017","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing financial interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"43930"}}